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Leeches provide source for cardiovascular drugs The leech has recently confirmed its biomedical interest for scientists by showing that it contains an extensive list of new potential molecules that may become useful tools in the treatment of cardiovascular diseases. view more (2005-10-26)
Mutant rats resist warfarin A new series of mutations have been discovered that allow rats to resist the effects of the popular poison warfarin. Research published in the open access journal BMC Genetics describes eighteen new genetic changes found in rats from four continents. view more (2009-02-06)
Blood clots can be treated by injections at home Treatment of blood clots in the deep veins of the legs or the lungs with an older, less expensive form of the anticoagulant medication heparin can be just as safe and effective as similar treatment with a newer and more expensive heparin. view more (2006-08-23)
Mayo researchers explore reasons for complications with kidney failure patients Mayo Clinic researchers searching for explanations of high mortality rates among kidney failure patients undergoing hemodialysis are focusing their attention on the use of heparin, a drug used to reduce clotting of the blood. view more (2005-08-18)
Blood-compatible nanoscale materials possible using heparin Researchers from Rensselaer Polytechnic Institute have engineered nanoscale materials that are blood compatible using heparin, an anticoagulant. The heparin biomaterials have potential for use as medical devices and in medical treatments such as kidney dialysis. view more (2006-05-08)
Antibiotics help combat dangerous tropical disease The disease is triggered off by the bite of an infected mosquito: together with its anticoagulant the mosquito pumps threadworm larvae into its host's body. These gravitate towards the lymph nodes, where they grow into threadworms which may be up to ten centimetres long. view more (2005-06-27)
Bacterial pneumonia patients at increased risk of major heart problems A new study suggests patients hospitalized with pneumonia may be at serious risk of new or worsening heart problems. view more (2007-06-19)
Genetics determine optimal drug dose of common anticoagulant Genetic testing can be used to help personalize the therapeutic dosage of warfarin, a commonly-used anticoagulant, according to research published in the September 1, 2007, issue of Blood, the journal of the American Society of Hematology. This result represents one of the first applications of using an individual's genetic information to guide... view more... (2007-08-22)
ESC Congress 2004: Efficacy and safety of ximelagatran confirmed for stroke prevention in atrial fibrillation European Society of Cardiology Congress (ESC), Munich, Germany: Results presented today from the final pooled analysis of SPORTIF III and V1,2 confirm that ximelagatran - the first oral direct thrombin inhibitor (oral DTI) - is as effective as well-controlled warfarin, the current standard anticoagulant treatment for the prevention of stroke in... view more... (2004-08-29)
Self-management of anticoagulant therapy Research by Manon E Cromheecke and colleagues from the University of Amsterdam, Netherlands, shows that self-management of oral anticoagulant therapy is feasible and at least as effective as management by a specialist anticoagulation clinic. Vitamin K antagonist treatment is effective for prevention and treatment of thromboembolic events but... view more... (2000-07-05)
Early promise for treatment of Ebola (p 1953) Embargoed 0001 h (London time) 12 December 2003. Preliminary findings of an animal study in this week's issue of THE LANCET suggest that scientists have taken an important step towards a possible treatment strategy for the deadly Ebola virus. Haemorragic fever from the Ebola virus is fatal in up to 80%of cases in humans. The virus is thought to... view more... (2003-12-10)
Osteoporosis drug Fosamax linked to heart problem omen who have used Fosamax are nearly twice as likely to develop the most common kind of chronically irregular heartbeat (atrial fibrillation) than are those who have never used it, according to research from Group Health and the University of Washington published in the April 28 Archives of Internal Medicine. view more (2008-04-29)
Reduced Risk Of Recurrent Heart Attack With Anticoagulant Drug Results of a study in this week's issue of THE LANCET show that patients given the anticoagulant drug, bivalirudin, had a reduced risk of recurrent heart attack compared with patients given conventional treatment with heparin. The combination of anticoagulant therapies (fibrinolytic therapy and the use of unfractionated heparin) for acute heart... view more... (2001-11-28)
Research highlights new approaches to prevent blood clots Blood clotting, or coagulation, is an important process that prevents excessive bleeding when a blood vessel is injured. view more (2008-12-08)
Less expensive anti-clotting medication appears as safe and effective as more expensive treatment Subcutaneous (beneath the skin) injection of the original and less expensive form of the anticoagulant medication heparin is as effective and safe as subcutaneous administration of the newer and more expensive low-molecular-weight heparin for treatment of venous thromboembolism (blood clots in the deep veins of the legs or in the lungs). view more (2006-08-23)
Clumps of red and white blood cells may contribute to sickle cell disease It's long been known that patients with sickle cell disease have malformed, "sickle-shaped" red blood cells - which are normally disc-shaped - that can cause sudden painful episodes when they block small blood vessels. view more (2008-04-29)
Over-diagnosis Of Liver Failure After Paracetamol Poisoning? Danish authors of a Research letter in this week's issue of THE LANCET suggest that there is the potential for clinicians to mistakingly diagnose liver failure after moderate paracetamol poisoning by relying solely on the measurement of one diagnostic marker. The use of acetylcysteine after paracetamol poisoning is of known therapeutic benefit;... view more... (2002-10-09)
Researchers determine timing of administration of platelet-inhibiting drugs Clinicians should carefully weigh the risks and benefits of when to administer platelet glycoprotein IIb/IIIa (Gp IIb/IIIa) inhibitors for patients with acute coronary syndromes undergoing invasive treatment. view more (2007-02-14)
Computers pass dosage test for thrombosis drugs The largest ever study into the administration of blood thinning drugs like Warfarin has concluded that dosages calculated by computer are at least as safe and reliable as those provided by trained medical professionals. view more (2007-07-20)
UNC School of Pharmacy researchers create new synthetic heparin Researchers at the University of North Carolina at Chapel Hill have patented a synthetic version of the drug heparin, called Recomparin, that is less complex chemically and should be easier to produce than previous forms. view more (2007-09-24)
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