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Intraperitoneal chemotherapy administration prolongs survival for women with advanced ovarian cancer
A study featured in this month's edition of Gynecologic Oncology examines the challenges associated with the administration of intra-abdominal chemotherapy, also known as intraperitoneal (IP) chemotherapy. view more (2006-01-05)
Chemotherapy after surgery extends survival for patients with advanced endometrial cancer
A new study has shown for the first time that giving two chemotherapy drugs to women with advanced endometrial cancer after surgery reduced the risk of recurrence by 29% and extended survival by 32% compared with women who received whole abdominal irradiation. view more (2005-12-06)
Chemotherapy can be more toxic to brain cells than to cancer cells and may cause brain damage
Drugs used to treat cancer may damage normal, healthy brain cells more than the cancer cells they are meant to target. view more (2006-11-30)
Mystery solved: Gold's power against autoimmune diseases defined
Gold compounds have been used for the treatment of rheumatoid arthritis and other autoimmune diseases for more than 75 years, but until now, how the metals work has been a mystery. view more (2006-02-27)
Light activated anticancer drug targeted to DNA using cisplatin like sub-units
One of the most effective chemotherapy drugs against cancer is cisplatin because it attaches to cancer DNA and disrupts repair. view more (2006-03-27)
UC Davis researchers discover genetic switch involved in cells' response to radiation therapy
UC Davis Cancer Center researchers have discovered a genetic switch that causes cancer cells to become more sensitive to a drug administered to enhance radiation therapy effectiveness. view more (2005-11-17)
HtrA1 and resistance to chemotherapy in ovarian and gastric cancers
While many cancer patients initially have a favorable response to chemotherapy for the treatment of solid tumors, resistance to treatment often develops. view more (2006-06-09)
Hearing loss from chemotherapy underestimated
By 14, Peter Johnson had survived brain cancer and a relapse of the disease in his shoulder. But it was treatment for the last tumor that would create his life's greatest challenges. view more (2005-12-12)
New protein target may advance design of HIV and cancer drugs
Using small molecules containing platinum, Virginia Commonwealth University Massey Cancer Center researchers have created a process to inhibit a class of proteins important in HIV and cancer. view more (2006-05-31)
U of I scientist develops enzyme inhibitor that may slow cancer growth
University of Illinois scientist Tim Garrow, in collaboration with Jiri Jiracek of the Czech Academy of Sciences, has applied for a provisional patent on a class of chemicals that has future therapeutic uses in medicine, specifically cancer treatment. view more (2006-07-07)
Herceptin effective in breast cancer cells with low HER-2 levels
Northwestern University and Evanston Northwestern Healthcare researchers have discovered that the monoclonal antibody Herceptin (trastuzumab) used in combination with certain cancer chemotherapies effectively treats breast cancer tumors that produce low or undetectable amounts of the HER-2 oncogene but overexpress the growth factor heregulin... view more... (2006-08-11)
Enzyme crystal structure reveals 'unexpected' genome repair functions
The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double helix, an action that is critical to transcription and nucleotide excision repair (NER), as well as other cell processes. view more (2006-04-07)
Ovarian cancer responds to aspirin derivative with chemo
A new study using ovarian cancer cell lines shows promise in treating the deadly disease by combining the chemotherapy drug cisplatin with an aspirin-like compound to make recurrent cancer cells less resistant to the chemotherapy. view more (2006-02-16)
Dangerous glucose-hungry cervical tumors can be detected using PET scans
Cervical cancers that take up a lot of blood sugar, or glucose, are more resistant to treatment than those that are less glucose-hungry, according to research at Washington University School of Medicine in St. Louis. view more (2006-03-31)
Intravenous chemoradiation effective for inoperable head, neck cancer; easier for patients, doctors
Chemoradiation (radiation and chemotherapy given at the same time) given through a needle or tube inserted into a vein (intravenous) is as effective as treatment given directly to the tumor through a tube inserted into an artery (intra-arterial) for patients with inoperable head and neck cancer. view more (2006-11-07)
Advanced therapy offers cure for relapsed cancer patient
Testicular cancer patients who do not respond to traditional therapy can be cured with high-dose chemotherapy and a stem cell transplant. view more (2007-07-26)
Intensity-modulated radiation therapy reduces side effects for cervical cancer
Preliminary results from a University of Pittsburgh study evaluating extended-field intensity-modulated radiation therapy (IMRT) for cervical cancer found that it resulted in significantly reduced side effects and outcomes comparable to standard radiotherapy. view more (2006-11-08)
No benefit to increasing dose intensity of chemotherapy in osteosarcoma, study finds
A dose-intensive regimen of the chemotherapy drugs cisplatin and doxorubicin offered no clinical benefit over standard doses of the chemotherapy drugs in patients with a bone cancer called osteosarcoma, according to results from a randomized trial in the January 17 issue of the Journal of the National Cancer Institute. view more (2007-01-17)
Analysis shows combining sorafenib with carboplatin/paclitaxel adds no benefit in lung cancer
A clinical trial evaluating the benefit of adding the drug sorafenib to the combination of carboplatin/paclitaxel chemotherapy for lung cancer patients has been stopped based on results from an interim analysis, after an independent data monitoring committee concluded that the study would not meet its primary endpoint of improved overall survival. view more (2008-04-28)
New treatment option studied for bladder cancer
A chemotherapy regimen for patients with advanced bladder cancer who aren't eligible for standard treatment is under study at the Medical College of Georgia. view more (2007-10-30)
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