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Primrose oil component cuts levels of cancer-causing gene Her-2/neu
Gamma-linolenic acid (GLA), a substance in evening primrose oil and several other plant oils used in herbal medicine, inhibits action of Her-2/neu, a cancer gene that is responsible for almost 30 percent of all breast cancers. view more (2005-11-02)
Breast cancer drug receives FDA approval
A new use for the breast cancer drug Herceptin was approved by the FDA yesterday, a move that means more treatment options for the 25 percent of breast cancer patients with early-stage HER-2 positive breast cancer. view more (2006-11-20)
New Herceptin results confirm impressive reduction in risk of cancer returning
New Herceptin results confirm impressive reduction in risk of cancer returning in women with aggressive form of early-stage breast cancer. view more (2005-09-14)
Newly discovered gene may predict aggressive ovarian cancer
Johns Hopkins Kimmel Cancer Center researchers have linked alterations in a gene, called Rsf-1, to the most deadly ovarian cancers. view more (2005-09-30)
Herceptin treatment lowers recurrence rate in early breast cancer
The targeted drug trastuzumab, or Herceptin, previously shown to prolong survival in advanced breast cancer, dramatically reduced the chances of recurrence in patients with early-stage disease when given for one year following standard chemotherapy. view more (2005-10-20)
Breast stem cells have features similar to 'basal' tumors
The most aggressive form of breast cancer may originate from breast stem cells that have undergone genetic mishaps. view more (2006-07-20)
Mayo Clinic reports breakthrough treatment for breast cancer
In a joint paper, co-authored by Mayo Clinic's Edith Perez, M.D., and Edward Romond, M.D., of the National Surgical Adjuvant Breast and Bowel Project (NSABP), researchers report complete and combined results of two trials comparing adjuvant chemotherapy with or without concurrent trastuzumab treatment in women with surgically removed HER2-positive... view more... (2005-10-20)
Serendipity versus planning-cancer drugs of the future?
Delegates at the European Breast Cancer Conference (EBCC-5) were given two examples of promising new drugs to watch in the future-raloxifene and lapatinib. view more (2006-03-27)
New cellular flaw found in some virulent breast cancers
Researchers at Dana-Farber Cancer Institute have identified a molecular interaction that triggers a particularly aggressive form of breast cancer, and suggest that attacking this target with selective drugs might improve treatment. view more (2006-01-18)
OHSU researchers discover protein fragment that helps predict breast cancer outcome
Oregon Health & Science University Cancer Institute researchers have identified a protein fragment in some human breast cancers that may help predict a patient's chances of survival. view more (2006-01-16)
Yale scientists decipher 'wiring pattern' of cell signaling networks
A team of scientists at Yale University has completed the first comprehensive map of the proteins and kinase signaling network that controls how cells of higher organisms operate. view more (2005-12-01)
Order of chemotherapy, radiation has no effect on breast cancer survival
For women who have had surgery for early breast cancer, it may not matter whether they receive follow-up chemotherapy before, after or during radiation therapy, according to a new review of studies. view more (2006-10-31)
Targeting key proteins of carcinogenesis
Misfolded and disused proteins are eliminated by a cellular shredder called the proteasome. The cell labels the proteins it wants to dispose with Ubiquitin (Ub) in order to avoid the unwanted degradation of still needed proteins. view more (2007-06-25)
Herceptin plus chemotherapy significantly increases disease-free survival in breast cancer
Combining the molecularly targeted therapy Herceptin with chemotherapy in women with early stage breast cancer significantly improves disease-free survival for patients with a specific genetic mutation that results in very aggressive disease. view more (2006-12-18)
Headlines about Herceptin show equality of access to costly drugs must be tackled
The recent press coverage on the use of Herceptin (brand name for the drug trastuzumab) for treating breast cancer in its early stages shows that issues of equal access to costly but effective drugs must be confronted, says an editorial in this week's BMJ. view more (2005-11-04)
Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
Novel platform technologies and key advances in genomics are rapidly driving the development of molecular diagnostics, reports Genetic Engineering and Biotechnology News (GEN). view more (2008-10-06)
Analysis of breast-cancer gene role offers promising target
Researchers at UT Southwestern Medical Center have for the first time described how multiple copies of a gene are responsible for metastases in early-stage breast cancer and poor prognosis for patients. view more (2006-10-31)
Gene expression test reveals ER and HER-2 status of breast tumors
Two critical characteristics of breast cancer that are important to treatment can be identified by measuring gene expression in the tumor, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in Lancet Oncology online. view more (2007-02-15)
Study finds cardiac toxicity rates high with herceptin use
The first study to look at "real world" use of Herceptin in advanced breast cancer patients found a higher incidence of cardiac toxicity - 28 percent of patients treated - than clinical trials of the drug have reported to date, but also concluded that the majority of this heart damage could be reversed with treatment. view more (2006-08-15)
New role for sugars: Research shows connections between sugar modifications in cells and cancer
In a ground-breaking study published in the top journal, Cell, Dr. James Dennis, senior investigator at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital, has discovered a new role for sugars on proteins. view more (2007-04-06)
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