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Zeroing in on progeria: How mutant lamins cause premature aging Children diagnosed with Hutchinson-Gilford Progeria Syndrome (HGPS) race through life against an unfairly fast clock. Cases are extremely rare-one in 8 million births-but time plays cruel tricks on HGPS newborns. view more (2005-12-14)
Regulating the Nuclear Architecture of the Cell An organelle called the nucleolus resides deep within the cell nucleus and performs one of the cell's most critical functions: it manufactures ribosomes, the molecular machines that convert the genetic information carried by messenger RNA into proteins that do the work of life. view more (2006-12-11)
Scripps research team reverses Friedreich's ataxia defect in cell culture In the new study, the researchers tested a variety of compounds that inhibited a class of enzymes known as histone deacetylases in a cell line derived from blood cells from a Fredreich's ataxia sufferer. view more (2006-08-22)
Exploring the Dark Matter of the Genome Not so long ago, the difficult-to-sequence, highly repetitive, gene-poor DNA found in regions of chromosomes known as heterochromatin was called "junk." Like dark matter in the universe, the true nature of heterochromatin was unknown. view more (2007-06-18)
St. Jude study yields secrets of chromosome movement Investigators at St. Jude Children's Research Hospital have used the lowly yeast to gain insights into how a dividing human cell ensures that an identical set of chromosomes gets passed on to each new daughter cell. view more (2007-06-18)
Massive project reveals shortcomings of modern genome analysis The sequencing and comparison of 12 fruit fly genomes -- the result of a massive collaboration of hundreds of scientists from more than 100 institutions in 16 countries -- has thrust forward researchers' understanding of fruit flies, a popular animal model in science. view more (2007-11-08)
Scientists Clarify a Mechanism of Epigenetic Inheritance Although letters representing the three billion pairs of molecules that form the "rungs" of the helical DNA "ladder" are routinely called the human "genetic code," the DNA they comprise transmits traits across generations in a variety of ways, not all of which depend on the sequence of letters in the code. view more (2008-04-23)
Roles of DNA packaging protein revealed by Einstein scientists Scientists at Albert Einstein College of Medicine of Yeshiva University have found that a class of chromatin proteins is crucial for maintaining the structure and function of chromosomes and the normal development of eukaryotic organisms. view more (2009-02-13)
When every photon counts The eyes of nocturnal mammals have very large numbers of highly-sensitive rod photoreceptors (the cell type responsible for night vision). They have to perceive light which is less than a millionth of the intensity of daylight. view more (2009-04-17)
Stowers Institute's Workman Lab discovers novel histone demethylase protein complex The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell. view more (2008-12-08)
CSHL researchers map changing epigenetic modifications that enable transposons to run amok Much like cancer cells, plant cells grown for a long time outside of their normal milieu, in culture dishes, have highly unstable genomes. view more (2008-12-11)
CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments The DNA in the 23 pairs of chromosomes in each of the billions of cells of the human body is so tightly packed that it would measure six feet in length if stretched end to end. A genome of this size can squeeze into a cell's tiny nucleus because it is compressed into highly condensed chromatin fibers by proteins called histones. view more (2009-04-10)
NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development A new study published online in Nature Immunology ahead of the June 2009 print issue has found that homologous immunoglobulin (lg) alleles pair up in the nucleus at stages that coincide with V(D)J recombination of the heavy and light chain (Igh and Igk) loci. view more (2009-05-22)
A solution to Darwin's 'mystery of the mysteries' emerges from the dark matter of the genome Biological species are often defined on the basis of reproductive isolation. Ever since Darwin pointed out his difficulty in explaining why crosses between two species often yield sterile or inviable progeny (for instance, mules emerging from a cross between a horse and a donkey), biologists have struggled with this question. view more (2009-10-27)
Researchers discover mechanism that prevents two species from reproducing Cornell researchers have discovered a genetic mechanism in fruit flies that prevents two closely related species from reproducing, a finding that offers clues to how species evolve. view more (2009-10-27)
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