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Study finds genes that 'fine-tune' muscle development process
Scientists at the University of North Carolina at Chapel Hill have found two genes that are essential for the proper development of muscle. view more (2005-12-30)
MicroRNA tweaks protein that controls early heart development
Researchers at UT Southwestern Medical Center have discovered how a small molecule of RNA called microRNA - a chemical cousin of DNA - helps fine tune the production of a key protein involved in the early development of heart muscle. view more (2005-06-13)
Micro-molecule plays big role in birth defects
University of Florida researchers have learned how to selectively shut down a flyweight-sized genetic molecule that packs a heavyweight punch, a discovery that may help doctors better understand cancer, birth defects and other health problems. view more (2005-07-20)
Long-term memory controlled by molecular pathway at synapses
Harvard University biologists have identified a molecular pathway active in neurons that interacts with RNA to regulate the formation of long-term memory in fruit flies. view more (2006-01-13)
MicroRNAs play a big part in gene regulation-and evolution
egulating when and where certain proteins are made is crucial to the normal functioning of living things. To make proteins, information from DNA is transcribed into RNA molecules and then translated into the amino acids building blocks of proteins. view more (2005-06-24)
Jefferson researchers uncover genetic signature that predicts colon cancer
Researchers at Jefferson Medical College in Philadelphia have uncovered a genetic "signature" that accurately identifies colon cancer-a key, they hope, to better understand how the cancer develops. view more (2006-04-05)
University of Iowa scientists explore function of 'junk DNA'
University of Iowa scientists have made a discovery that broadens understanding of a rapidly developing area of biology known as functional genomics and sheds more light on the mysterious, so-called "junk DNA" that makes up the majority of the human genome. view more (2006-11-14)
Tiny RNA molecules fine-tune the brain's synapses
Non-coding regions of the genome - those that don't code for proteins - are now known to include important elements that regulate gene activity. view more (2006-01-19)
MicroRNA may have fail-safe role in limb development
A tiny strand of molecules plays a role in how our arms and legs develop and grow-a finding that sheds light on perplexing bits of material once dismissed as genetic "junk," say scientists at the University of Florida and Harvard University. view more (2005-12-02)
Study establishes new class of cancer-causing genes
Over the past few years, scientists have discovered that a new class of genetic regulators called "microRNAs" influences normal human growth and development. Now, researchers have found that microRNAs also play an important role in human cancer. view more (2005-06-08)
Biologists develop genome-wide map of miRNA-mRNA interactions
Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans). view more (2006-03-09)
Discovery suggests why stem cells run through stop signs
Everyone knows that stem cells are controversial. Many people know that stem cells can grow into virtually any cell type found in the body, from a red blood cell to a muscle cell to a brain cell. But no one really knows why stem cells continue to divide and renew themselves long after the point where other cells stop dividing. view more (2005-06-13)
Molecular steps involved in the creation of gene-silencing MicroRNAs identified
First discovered only a few brief years ago, microRNAs are small, remarkably powerful molecules that appear to play a pivotal role in gene silencing, one of the body's main strategies for regulating its genome. A scant 22 nucleotides in length, miRNAs appear to work by binding to and somehow interfering with messenger RNA, itself responsible for... view more... (2005-06-23)
MicroRNA processing and cancer
In an upcoming G&D paper, Dr. Scott Hammond (UNC-Chapel Hill) and colleagues describe a key regulatory step during microRNA biogenesis, which may underlie alterations of microRNA expression in cancer. view more (2006-08-01)
Xie Lab demonstrates the role of microRNA pathway
Ting Xie, Ph.D., Associate Investigator, and Zhigang Jin, Ph.D., Postdoctoral Research Associate in the Xie Lab, have published results showing that the microRNA pathway is essential for controlling self-renewal of germline stem cells and somatic stem cells in the Drosophila ovary. view more (2007-02-16)
Renegade RNA — Clues to cancer and normal growth
Researchers at Johns Hopkins have discovered that a tiny piece of genetic code apparently goes where no bit of it has gone before, and it gets there under its own internal code. view more (2007-01-05)
Twin molecular scissors link creation of microRNAs with gene-silencing
One of the body's primary strategies for regulating its genome is a kind of targeted gene silencing orchestrated by small molecules called microRNAs, or miRNAs. view more (2005-11-04)
UF scientists identify cancer virus' genetic targets
University of Florida researchers have identified specific human genes targeted by a virus believed to cause Kaposi's sarcoma, a rare form of cancer associated with AIDS and with organ transplants that causes patches of red or purple tissue to grow under people's skin. view more (2007-05-11)
New biomarkers for lupus found
A Wake Forest University School of Medicine team believes it has found biomarkers for lupus that also may play a role in causing the disease. view more (2006-11-13)
MicroRNAs have shaped the evolution of the majority of mammalian genes
RNA continues to shed its reputation as DNA's faithful sidekick. Now, researchers in the lab of Whitehead Institute Member David Bartel have found that a class of small RNAs called microRNAs influence the evolution of genes far more widely than previous research had indicated. view more (2005-11-30)
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