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Movement of chromosome in nucleus visualized
The cell is understood to be highly organized, with specialized areas for different functions and molecular motors shuttling components around. view more (2006-04-18)
Inhibiting cell process may give cancer drug a boost
A molecule that interferes with the internal scaffolding that shapes the cell may kill cancer cells, retard the growth of tumors and give a boost to a common chemotherapy drug. view more (2006-05-04)
'Muscle' protein drives prostate cancer
Researchers at the Johns Hopkins Kimmel Cancer Center have for the first time implicated the muscle protein myosin VI in the development of prostate cancer and its spread. view more (2006-11-09)
Adult stem cells are touchy-feely, need environmental clues
A certain type of adult stem cell can turn into bone, muscle, neurons or other types of tissue depending on the "feel" of its physical environment. view more (2006-08-25)
Image of myosin-actin interaction revealed in cover story of Molecular Cell
Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model of protein motility and muscle contraction. view more (2005-09-30)
A new focus for the mechanism of nerve growth
Researchers at Yale shed new light on the mechanism of nerve cell growth by identifying novel functions for a molecular "motor" protein, myosin-II, according to an article in the March issue of Nature Cell Biology. view more (2006-03-20)
Spiders Help Scientists Discover How Muscles Relax
Using muscle tissue from tarantulas, an HHMI international research scholar and his colleagues have figured out the detailed structure and arrangement of the miniature molecular motors that control movement. view more (2005-08-25)
Tiny molecule controls stress-induced heart disease
A tiny snippet of RNA, a chemical cousin of DNA, controls damage to the heart under several types of stress, researchers at UT Southwestern Medical Center have found. view more (2007-03-23)
Discovery of agile molecular motors could aid in treating motor neuron diseases
Over the last several months, the labs of Yale Goldman, MD, PhD, Director of the Pennsylvania Muscle Institute at the University of Pennsylvania School of Medicine, and Erika Holzbaur, PhD, Professor of Physiology, have published a group of papers that, taken together, show proteins that function as molecular motors are surprisingly flexible and... view more... (2006-07-18)
Going Ballistic: Soft Structures Could Spell The End For Slow Shrimps
Many animals are able to rapidly extend their tongues to catch prey. In fact, the chameleon extends its tongue at an acceleration rate of 500 metres per second square - generating 5 times the G force experienced by an F-16 fighter during its most demanding maneouvre! New research presented at the Society for Experimental Biology conference in... view more... (2002-04-09)
Researchers find level of special protein is critical to proper formation of muscles
Proper formation of the proteins that power heart and skeletal muscle seems to rely on a precise concentration of a "chaperone" protein known as UNC-45, according to a new study. view more (2007-04-25)
Scientists identify motor that powers parasitic cell invasion
The development of drugs to combat some of the world`s most serious parasitic diseases is a step nearer with the discovery of a widely-shared gene that helps parasites to invade host cells. The new understanding of the gene`s role in the single-celled parasite Toxoplasma gondii gives scientists a target to block that could stop the parasite... view more... (2002-10-24)
A stepwise retreat: how immune cells catch pathogens
To protect us from disease our immune system employs macrophages, cells that roam our body in search of disease-causing bacteria. view more (2007-07-12)
Light shed on vision and hearing disorders
The most common hereditary condition that affects both hearing and vision is Usher Syndrome (USH). In the next issue of The EMBO Journal, scientists at the Institut Pasteur report on studies that have established the first link between Myosin VIIa, Cadherin 23 and Harmonin b. These three proteins were previously known to be involved in the... view more... (2002-12-16)
Dense tissue promotes aggressive cancers
New research may explain why breast cancer tends to be more aggressive in women with denser breast tissue. Breast cancer cells grown in dense, rigid surroundings step up their invasive activities, Vanderbilt-Ingram Cancer Center investigators report in the Sept. 9 issue of Current Biology. view more (2008-08-25)
What Are Muscle Proteins Doing in the Nucleus?
The proteins actin and myosin have a firm place in the muscles where they are responsible for contraction. While recent investigations have shown that they are also found in the nucleus, it has been unclear to date just what they are doing there. Now an international team of investigators headed by Professor Dr. Ingrid Grummt, head of the Division... view more... (2005-02-01)
Molecular motors may speed nutrient processing
Matthew Tyska, Ph.D., recalls being intrigued, from the first day of his postdoctoral fellowship in 1999, with a nearly 30-year-old photograph. It was an electron micrograph that showed the internal structures of an intestinal cell microvillus, a finger-like protrusion on the cell surface. Microvilli are common features on the epithelial cells... view more... (2007-05-31)
Ancient protein offers clues to killer condition
More than 600 million years of evolution has taken two unlikely distant cousins - turkeys and scallops - down very different physical paths from a common ancestor. But University of Leeds researchers have found that a motor protein, myosin 2, remains structurally identical in both creatures. view more (2008-05-13)
Listeria monocytogenes: how can a relatively innocuous food-borne pathogen induce a potentially fatal disease?
Listeria monocytogenes (L. monocytogenes) provokes listeriosis, a potentially fatal food-borne disease, which mainly affects pregnant women and immuno-compromised individuals where it can lead to death rate as high as 30%. Understanding the mechanism behind the disease is crucial to dealing with this serious health problem. In the latest Journal... view more... (2004-04-20)
From mother to daughters: A central mystery in cell division solved
Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have identified a key step required for cell division in a study that could help improve therapies to treat cancer. view more (2008-12-09)
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