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Gene that makes people 'early to bed and early to rise' demystified The recent discovery that a mutant "clock" gene made some people "early to bed and early to rise," a condition known as familial advanced sleep phase syndrome (FASPS), offered one of the first glimpses into the genetic basis of sleep in humans. view more (2007-01-12)
Membrane research opens window to benefits for plants, humans A wilting, water-starved houseplant and flood-covered crops have something in common. That knowledge, gleaned from spinach and researchers on two continents, potentially could open the gate to advances in both plant and human health. view more (2005-12-21)
Early to bed, early to rise In an upcoming G&D paper, a team of German scientists presents a genetic basis for understanding human morning lark behavior. Dr. Achim Kramer (Charité Universitaetsmedizin Berlin) and colleagues have uncovered a genetic cause for the human familial advanced sleep phase syndrome (FASPS), which causes people to both go to sleep and wake up... view more... (2006-09-20)
Protein linked to growth of organs and cancer Johns Hopkins scientists have identified a protein in fruit flies whose counterpart product in humans may help cause cancer. view more (2005-08-12)
Enzyme complex thought to promote cancer development can also help prevent it In a case of basic science detective work, researchers at The University of Texas M. D. Anderson Cancer Center have solved the puzzle of the "inconsistent biomarker" and, in the process, may have discovered an agent that can suppress cancer development. view more (2005-10-14)
How Rett Syndrome mutation targets the brain Researchers have pinpointed why mutations that cause Rett Syndrome (RTT)-among the leading causes of mental retardation in females-specifically target the brain rather than other body tissues. view more (2006-10-19)
Aspirin discovery may improve cancer treatments Salicylates, including aspirin, are used to treat a range of inflammatory conditions and can be used to prevent diseases such as cancer, but the way aspirin works is not yet fully understood. view more (2007-04-06)
A molecular basis for selective therapeutic intervention in Alzheimer's disease Alzheimer's disease, a complex neurological disorder, has as one of its hallmarks the presence of senile plaques in the brains of affected individuals. view more (2005-10-07)
Picking apart how neurons learn Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells. view more (2006-03-30)
Computational model simulates AZT metabolism in mitochondria Researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed a computational model that allows scientists to better understand the metabolism and toxicity of the HIV/AIDS drug zidovudine (azidothymidine, AZT). view more (2006-07-25)
Link identified between age, cardiovascular disease Researchers in the Linus Pauling Institute at Oregon State University have discovered a fundamental mechanism that causes aging blood vessels to lose their elasticity - a literal "hardening of the arteries" that is often a prelude to high blood pressure and cardiovascular disease. view more (2006-11-06)
Neutrophils in rheumatoid arthritis: How to lessen inflammation but still fight infection Neutrophils, which quickly congregate at the sites of infection and inflammation, are capable of ingesting microorganisms or other particles. view more (2006-06-16)
'Memory molecule' stores memories in neocortex The "memory storage molecule" - PKMzeta - maintains long-term memories in the neocortex and its presence is continually required in order for the memory to endure, according to a finding by researchers at the Weizmann Institute in Rehovot, Israel and SUNY Downstate Medical Center in Brooklyn, New York. view more (2007-08-17)
Funnel in the eye: Signal focusing increases photosensitivity In poor light the eyes of mice react like some digital cameras: they reduce their resolution while at the same time increasing their sensitivity. Specialists in the retina focus the information of several light sensor cells for this purpose. view more (2006-11-03)
Researchers figure out what makes a simple biological clock tick An interdisciplinary team of researchers at Vanderbilt University has analyzed the simplest known biological clock and figured out what makes it tick. view more (2007-03-27)
Study: Brain connections strengthen during waking hours, weaken during sleep Most people know it from experience: After so many hours of being awake, your brain feels unable to absorb any more-and several hours of sleep will refresh it. view more (2008-01-21)
Insights into activity-dependent neuronal growth through RSRF-supported research Brain-derived neurotrophic factor (BDNF) has been a subject of keen interest in neuroscientific circles for several years, turning up in studies of conditions ranging from central hypoventilation syndrome to obsessive-compulsive disorder, depression, bipolar disorder and schizophrenia - a range of disorders uncannily parallel to those produced by... view more... (2006-10-23)
Mutation improves memory, may lead to memory-enhancing pill A mind-altering mutation in mice results in an enhanced long-term memory, researchers report in the April 6, 2007 issue of the journal Cell, published by Cell Press. These findings point to a potential target for the development of a drug to treat memory loss, according to the researchers. view more (2007-04-06)
One Signal Elicits Thousands of Answers Cell signaling mechanisms often transmit information via protein modifications, most importantly the reversible attachment of phosphate, the so-called protein phosphorylation. view more (2006-11-13)
Scientists discover that three molecules may be developed into new Alzheimer's drugs A team of scientists has discovered three molecules -- from a search of 58,000 compounds -- that appear to inhibit a key perpetrator of Alzheimer's disease. view more (2005-07-25)
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