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Typhoid fever led to the fall of Athens
Scientists have for many years debated the cause of the Plague of Athens. Analysis carried out by Manolis Papagrigorakis and colleagues using DNA collected from teeth from an ancient Greek burial pit points to typhoid fever as the disease responsible for this devastating epidemic. view more (2006-01-24)
Monkeypox mystery: New research may explain why 2003 outbreak in the US wasn't deadly
An outbreak of 72 cases of monkeypox in the United States during the summer of 2003 didn't produce a single fatality, even though the disease usually kills 10 percent of those infected. view more (2005-07-18)
Novel virus entry mechanism could lead to new drugs against poxviruses
Research published in the Proceedings of the National Academy of Sciences on 11 April describes how the Imperial College London team discovered the mechanism allowing Vaccinia virus to shed its outer lipid membrane and enter cells. The mechanism is unique in virology and paves the way for development of new antiviral drugs. view more (2006-04-12)
Penn researchers determine structure of smallpox virus protein bound to DNA
Researchers at the University of Pennsylvania School of Medicine have determined the structure of an important smallpox virus enzyme and how it binds to DNA. view more (2006-08-07)
New technique points to safer, more efficient vaccination
Researchers have demonstrated a technique that has the potential to reduce the toxicity of vaccines and to make smaller doses more effective, according to a study published in PLoS Pathogens. view more (2005-12-30)
LIAI scientists make major finding on potential smallpox treatment
Researchers at the La Jolla Institute for Allergy & Immunology (LIAI) have made a major advancement toward protecting society against a smallpox outbreak by identifying an antibody in humans that quickly fights the smallpox virus. view more (2005-09-14)
LIAI finding gives boost to bioinformatics use in fighting disease
The use of computers to advance human disease research — known as bioinformatics — has received a major boost from researchers at the La Jolla Institute for Allergy & Immunology (LIAI), who have used it to successfully predict immune response to one of the most complex viruses known to man — the vaccinia virus, which is used... view more... (2006-06-16)
Researchers develop new testing methods for potential monkeypox or smallpox outbreak
Researchers at the Vaccine and Gene Therapy Institute (VGTI) at Oregon Health & Science University have developed new diagnostic methods to better detect future monkeypox or smallpox outbreaks. view more (2005-08-09)
Program may improve physicians' knowledge about diseases caused by bioterrorism agents
An online education program improved physicians' knowledge about the diagnosis and management of diseases caused by bioterrorism agents, such as anthrax, smallpox and plague. view more (2005-09-27)
Institute for Animal Health at the BA Festival: Rinderpest on the ropes
New vaccines could aid efforts to rid the world of cattle plague, according to research presented today (Tuesday 09 September 2003) at the BA festival of Science. Professor Tom Barrett and colleagues at the Institute for Animal Health (IAH) have produced several candidate vaccines, using the latest DNA technology, which could assist in the final... view more... (2003-09-02)
Funding the 'war on terror' could cost millions of lives
Funding the "war on terror" could cost the lives of millions of Americans, says a senior doctor in this week's BMJ. view more (2005-09-09)
Measuring pandemic preparedness
A federal plan to vaccinate hospital healthcare workers against a threat of smallpox fell short on several levels, according to the first metric analysis of the prophylactic health program. view more (2006-11-30)
Researchers discover new battleground for viruses and immune cells
Vaccines have led to many of the world's greatest public health triumphs, but many deadly viruses, such as HIV, still elude the best efforts of scientists to develop effective vaccines against them. view more (2008-02-07)
Serious adverse reactions to smallpox vaccine appear to be limited
There was a low rate of life-threatening adverse reactions to the smallpox vaccine administered to potential first responders to a bioterrorism incident, possibly attributable to rigorous vaccine safety screening and educational programs. view more (2005-12-07)
First evidence of gene therapy for abnormal blood vessel growth in newborns
The first evidence of the potential for gene therapy to treat eye disease that stems from abnormal blood vessel growth is revealed in research published in the British Journal of Ophthalmology. Gene therapy is a relatively new and much heralded therapeutic approach. But despite the advances in molecular genetics, attempts to target organs or... view more... (2001-07-18)
Cancer drug slows poxvirus in mice
Mice given a relatively new cancer drug can survive an otherwise lethal dose of vaccinia virus, a relative of smallpox virus, report scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. view more (2005-06-27)
Tiny avalanche photodiodes target bioterrorism agents
After the anthrax attacks in the United States in 2001 the threat of a larger and more deadly bioterrorism attack - perhaps from smallpox, plague or tularemia - became very real. But the ability to detect such biological agents and rapidly contain an attack is still being developed. view more (2005-09-14)
Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack
Mass vaccination would not be necessary in the event of a large-scale smallpox bioterrorist attack in the United States. view more (2006-10-17)
Poxvirus' ability to hide from the immune system may aid vaccine design
The cowpox virus, a much milder cousin of the deadly smallpox virus, can keep infected host cells from warning the immune system that they have been compromised, researchers at Washington University School of Medicine in St. Louis have found. view more (2007-11-16)
The release of new data from the HVTN 502 HIV vaccine study
The new analyses revealed today from the STEP HIV vaccine clinical trial are both disappointing and puzzling. At this time, the data offer no clear explanations as to why the vaccine showed no measurable efficacy or why among individuals with background immunity to the adenovirus vector, there were more HIV infections in the vaccinees as compared... view more... (2007-11-08)
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