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Researchers zero in on estrogen's role in breast-cancer cell growth
Why do estrogen-dependent breast-cancer cells grow and spread rapidly? Researchers at the University of Illinois at Urbana-Champaign say it may be because estrogen virtually eliminates levels of a vitally important regulatory protein. view more (2005-09-12)
Mechanism for Epstein-Barr virus protein's role in blood cancers discovered
Earlier this year, researchers at the University of Pennsylvania School of Medicine identified a link between a critical cancer pathway and an Epstein-Barr Virus (EBV) protein known to be expressed in a number of EBV-associated cancers. view more (2005-12-27)
New pathway could present an intervention point for cancer treatment
A new cellular pathway leads to destruction of a protein that promotes growth of breast, prostate and similar cancers and could provide a new avenue through which to pursue treatment of such diseases. view more (2006-01-27)
Brain enzyme treatment relieves memory lapse in Alzheimer's mice
An enzyme that helps neurons rid themselves of excess or aberrant proteins is required for normal brain function. view more (2006-08-25)
Bacterial protein mimics host to cripple defenses
Like a wolf in sheep's clothing, a protein from a disease-causing bacterium slips into plant cells and imitates a key host protein in order to cripple the plant's defenses. view more (2005-12-23)
Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
Everyone knows mutations - genetic mistakes in DNA, the material of heredity - are bad: The more mutations in the cell's DNA, the higher the risk of cancer developing. view more (2006-05-05)
Emory scientists discover unique binding method for essential cellular protein ubiquitin
Researchers at Emory University School of Medicine have uncovered new information about the molecular pathway used by ubiquitin, an essential protein that helps regulate the amounts and locations of other proteins within cells. view more (2006-03-24)
An AIDS-related virus tricks cells to become tumors, new Penn study finds
Researchers at the University of Pennsylvania School of Medicine have discovered how the Kaposi's sarcoma-associated herpesvirus (KSHV) subverts a normal cell process in order to promote tumor growth. view more (2006-11-09)
Water is 'designer fluid' that helps proteins change shape, scientists say
Ubiquitous on Earth, water also has been found in comets, on Mars and in molecular clouds in interstellar space. Now, scientists say this common fluid is not as well understood as we thought. view more (2008-08-07)
Targeting key proteins of carcinogenesis
Misfolded and disused proteins are eliminated by a cellular shredder called the proteasome. The cell labels the proteins it wants to dispose with Ubiquitin (Ub) in order to avoid the unwanted degradation of still needed proteins. view more (2007-06-25)
Novel regulation of the common tumor suppressor PTEN
PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation and survival processes. When mutated or deleted, it causes cancers of the prostate, breast, colon, and brain. view more (2007-01-12)
Study reveals how cells destroy faulty proteins in cystic fibrosis
The cellular system that degrades faulty proteins created by the cystic fibrosis gene has been identified by University of North Carolina at Chapel Hill scientists. view more (2006-08-11)
Telling axons where to go - and grow
In a recent study, Dr. Ingolf Bach and colleagues from the University of Massachusetts Medical School, Worcester and the University of Hamburg (Germany) describe a novel role for the ubiquitin/proteosome protein degradation pathway in the regulation of local actin dynamics in neurons. view more (2005-10-03)
MIT finds most complex protein knot ever seen
An MIT team has discovered the most complicated knot ever seen in a protein, and they believe it may be linked to the protein's function as a rescue agent for proteins marked for destruction. view more (2006-09-26)
Researchers find two biomarkers with potential to predict breast cancer spread
Expression of two different proteins taken from primary tumor biopsies is highly associated with spread of breast cancer to nearby lymph nodes, according to researchers who say this protein profile could help identify at an early stage those patients whose disease is likely to metastasize. view more (2006-12-18)
Researchers find cause of frontotemporal dementia
Frontotemporal Dementia (FTD) is the second major form of dementia. view more (2006-07-17)
Glue inside the cell: Ubiquitin builds up an immune response
Ubiquitin is a small protein, which can be attached to other cellular proteins, a process known as ubiquitination. Discoveries in the 1980 th on a key function of ubiquitination in the regulation of protein degradation where awarded with the Nobel Prize for chemistry in 2004. view more (2007-10-22)
Proteasome activator enhances survival of Huntington's disease neuronal model cells
To function, each living cell needs both to build new and to degrade old or damaged proteins. To accomplish that, a number of intracellular systems work in concert to keep the cell healthy and from clogging up with damaged proteins. view more (2007-02-28)
The Nobel Prize in Chemistry 2004
The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2004 "for the discovery of ubiquitin-mediated protein degradation" jointly to view more (2004-10-06)
Discovery in plants suggests entirely new approach to treating human cancers
For the first time, scientists from the University of Washington School of Medicine, Indiana University Bloomington and the University of Cambridge have determined how a plant hormone — auxin — interacts with its hormone receptor, called TIR1. view more (2007-04-05)
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