Brightsurf Science News & Current Events

April 02, 2011
Genetic variation linked to longer telomeres and lower risk of bladder cancer
Using new genetic information, scientists have linked a commonly found human genetic variant with both longer telomeres and reduced risk of bladder cancer, according to findings presented at the AACR 102nd Annual Meeting 2011, held April 2-6, and simultaneously published in Cancer Prevention Research, a journal of the American Association for Cancer Research.

Earth's oldest records of sea-floor spreading
A paper about early Pre-cambrian ophiolites was published in the March 2011 issue of of Science China: Earth Sciences.

Investigational compound PEG-interferon lambda achieved higher response rates with fewer flu-like and musculoskeletal symptoms and cytopenias than PEG-interferon alfa in Phase IIb study of 526 treatment-naive hepatitis C patients
Bristol-Myers Squibb Company today announced results from the Phase IIb EMERGE clinical trial, in which treatment with the investigational compound PEG-Interferon lambda and ribavirin achieved higher rates of rapid virologic response in genotypes 1, 2, 3, and 4, and complete early virologic response in genotypes 1 and 4 than the standard regimen of PEG-Interferon alfa and ribavirin in treatment-naive patients chronically infected with hepatitis C.

Mum's the word when it comes to children's happiness
Young people's satisfaction with their family situation is clearly related to the quality of relationships with parents and especially their mother's happiness.

Combining MEK and PI3K inhibitors appears encouraging in a safety study with early signs of anti-tumor activity
The combination of two compounds that inhibit two of the most frequently mutated cancer pathways is showing promise in an ongoing Phase I trial, according to data presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.

Antidepressants linked to thicker arteries
Antidepressant use has been linked to thicker arteries, possibly contributing to the risk of heart disease and stroke, in a study of twin veterans.

New inhibitor prevented lesions, reduced tumor size in basal cell cancer
A new hedgehog pathway inhibitor demonstrated efficacy in preventing and treating basal cell cancer among patients with basal cell nevus syndrome, a rare inheritable disease, according to Phase II data presented at the AACR 102nd Annual Meeting 2011, held April 2-6.

Chronic stress of cancer causes accelerated telomere shortening
Results of a study presented at the AACR 102nd Annual Meeting 2011, held here April 2-6, lend credence to the idea that improving quality of life affects stress-related biological markers and possibly the health of people with cancer.

Target for lung cancer chemoprevention identified
Scientists have identified a biomarker for measuring the success of lung cancer chemoprevention, an emerging frontier in the fight against this disease that has long been stymied by a lack of measureable outcomes.

Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients
Thalidomide has shown potential to be used as the first adjuvant therapy for hepatocellular carcinoma, according to data presented at the International Liver Congress 2011.

Amphiphilic dendronized homopolymers
A novel class of amphiphilic dendronized homopolymers has been reported by the department of polymer materials, Shanghai University.

Data suggest liver experts should take care when prescribing novel antiviral HCV drugs
Data presented at the International Liver CongressTM highlight the fact that new novel antiviral compounds for the treatment of hepatitis C virus must be prescribed and monitored by experts and specialists to ensure resistance is minimized.

Investigational direct-acting antiviral BMS-790052 plus PEG-interferon alfa and ribavirin achieved up to 92 percent sustained virologic response in Phase II dose-ranging study of treatment-naïve hepatitis C patients
Bristol-Myers Squibb Company today announced results from a Phase II clinical trial in which treatment with the investigational direct-acting antiviral BMS-790052, an NS5A replication complex inhibitor, in combination with PEG-Interferon alfa and ribavirin.

Square Kilometre Array telescope project announces the establishment of a Founding Board
2 April 2011, Rome, Italy - Nine national governmental and research organisations have today established a Founding Board for the global Square Kilometre Array (SKA) project.

Quadruple therapy shows 100 percent SVR for HCV patients previously unresponsive to treatment
Exciting new data presented today at the International Liver Congress 2011 show that quadruple therapy in chronic hepatitis C (HCV) patients suppressed the emergence of resistant variants and resulted in a 100 percent rate of sustained virological response -- undetectable HCV RNA -- 12 weeks after treatment (SVR12).

2 sets of genes predict response to lung cancer drug
Two sets of gene expression profiles predict response to a common lung cancer drug for patients that have no guiding indicators for their treatment now, scientists from the University of Texas MD Anderson Cancer Center report at the AACR 102nd Annual Meeting.

Entry inhibitors show promise as drugs with new MOA for treatment of HBV and HDV infection
Promising new viral hepatitis data presented today at the International Liver Congress show that entry inhibitors a new mechanism of action for drugs to treat viral hepatitis could provide the first new hepatitis B and hepatitis D treatments for many years.

In vitro infection and replication of hepatitis E virus in human hepatocytes
Groundbreaking data presented today demonstrate, for the first time, in vitro infection and replication of swine hepatitis E virus (HEV) in human hepatocytes.

Biodiversity and taphonomy of the early Cambrian Guanshan biota, eastern Yunnan
The Guanshan biota is an important Burgess Shale-type fossil Lagerstte from East Yunnan, SW China with exceptional preservation of soft-tissues after the discovery of the Chengjiang fauna and the Kaili biota.

BATTLE researchers identify new biomarkers for EGFR inhibition
Scientists are continuing their work on the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination trial -- known more commonly as the BATTLE trial -- and presented updated results at the AACR 102nd Annual Meeting 2011, held here April 2-6.

DNA of 50 breast cancer patients decoded
In the single largest cancer genomics investigation reported to date, scientists have sequenced the whole genomes of tumors from 50 breast cancer patients and compared them to the matched DNA of the same patients' healthy cells.

Engineers create vibrant colors in vertical silicon nanowires
Engineers may soon be singing,

PegIFN-lambda shows superior virological response and improved safety than PegIFN-alpha-2a
Highly exciting new data presented today at the International Liver Congress found Pegylated Interferon-lambda (PegIFN-lambda) shows superior virological response in HCV patients of genotypes 1-4, with improved safety and tolerability, compared to Pegylated Interferon-alpha (PegIFN-alpha-2a), the current standard of care in chronic HCV.

Genetic variation cuts bladder cancer risk, protects chromosome tips
A common genetic variation links to both bladder cancer risk and to the length of protective caps found on the ends of chromosomes, scientists at the University of Texas MD Anderson Cancer Center reported today at the AACR 102nd Annual Meeting.

The AACR increases focus on clinical trials
The American Association for Cancer Research Annual Meeting continues to be a showcase for the most cutting edge science in cancer, and this year's meeting, held here April 2-6, will include an increased focus on clinical trials that will impact patient care.

DNA of 50 breast cancer patients decoded
In one of the largest cancer genomics investigations reported to date, scientists have sequenced the whole genomes of tumors from 50 breast cancer patients and compared them to the matched DNA of the same patients' healthy cells.

New data show non-alcoholic fatty liver disease will reach epidemic status in the US
According to new data presented today at the International Liver Congress, the United States could soon be faced with an epidemic of non-alcoholic fatty liver disease, one of the major contributing factors of chronic liver disease, considered as one of the major causes of morbidity and mortality worldwide.
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