Brightsurf Science News & Current Events

November 13, 2011
Paying for sex and 'playing dead' - the deceitful gift-giving spider
Male nursery web spiders prepare silk-wrapped gifts to give to potential mates.

Tamoxifen resistance -- and how to defeat it
In the last three decades, thousands of women with breast cancer have taken the drug tamoxifen, only to discover that the therapy doesn't work, either because their tumors do not respond to the treatment at all, or because they develop resistance to it over time.

HDAC inhibitor may overcome resistance to common breast cancer drug
Researchers have shown how estrogen receptor-positive breast cancer tumors become resistant to tamoxifen, the only approved hormonal therapy for premenopausal patients with this type of breast cancer.

Human memory: Performance linked to changes in brain structure and function
New research released today provides insight into one of neuroscience's most intriguing mysteries: how the human brain learns and remembers.

CSHL team solves a protein complex's molecular structure to explain its role in gene silencing
CSHL scientists and their collaborators at St. Jude's Research Hospital have discovered new details of how the various domains of the RNA-Induced Initiation of Transcriptional gene Silencing complex contribute to heterochromatin assembly and gene silencing.

Sugar-sweetened beverages may increase cardiovascular risk in women
Drinking two or more sugar-sweetened beverages a day may expand a woman's waistline and increase her risk of heart disease and diabetes, according to research presented at the American Heart Association's Scientific Sessions 2011.

Professional dental cleanings may reduce risk of heart attack, stroke
Professional tooth scaling was associated with fewer heart attacks and strokes in a study from Taiwan presented at the American Heart Association's Scientific Sessions 2011.

Improved memory efficiency seen after aerobic exercise in fibromyalgia patients
Areas of the brain responsible for pain processing and cognitive performance changed in fibromyalgia patients who exercised following a medication holiday, say researchers from Georgetown University Medical Center.

Older and sometimes wiser: Studies point to ways to improve cognition in older adults
New human research released today shows the benefits and challenges for the aging brain.

Patients with hypertrophic cardiomyopathy live into their 90s
Hypertrophic cardiomyopathy is consistent with survival to normal life expectancy, including particularly advanced age into the tenth decade of life, with demise ultimately largely unrelated to this disease, according to a study being presented Nov.

Researchers develop more effective way to discover and test potential cancer drugs
Researchers have created a new phenotypic screening platform that better predicts success of drugs developed to prevent blood vessel tumor growth when moving out of the lab and onto actual tumors.

Antifolates show promise against NSCLC subtype
Patients with non-small cell lung cancer who have mutations in the KRAS gene should respond well to the antifolate class of drugs, according to results of a recent study conducted by Quintiles comparing human lung cancer cell lines and patients.

New approaches may prevent certain side effects in BRAF mutation-positive melanoma
Findings from preclinical studies in a skin cancer model showed that next-generation BRAF inhibitors used alone, or first-generation BRAF inhibitors used in combination with an epidermal growth factor receptor inhibitor, may have the potential to prevent drug-induced skin lesions in BRAF mutation-positive patients treated for melanoma.

White pediatric heart transplant patients more likely than non-whites to survive long term
White heart transplant patients under the age of 18 are more than twice as likely to be alive a decade after surgery as their African-American counterparts, new Johns Hopkins research suggests.

Abused girls may have higher risk of heart disease, stroke as adults
Sexually and physically abused girls may have higher risks for heart attacks, heart disease and strokes as adults, according to research presented at the American Heart Association's Scientific Sessions 2011.

BUSM: Severe sepsis, new-onset AF associated with increased risk of hospital stroke, death
A recent study led by researchers at Boston University School of Medicine (BUSM) shows an increased risk of stroke and mortality among patients diagnosed with severe sepsis and new-onset atrial fibrillation (AF) during hospitalization.

A more flexible window into the brain
A team of researchers co-led by the University of Pennsylvania has developed and tested a new high-resolution, ultra-thin device capable of recording brain activity from the cortical surface without having to use penetrating electrodes.

Newly identified gene mutation adds to melanoma risk
A major international study has identified a novel gene mutation that appears to increase the risk of both inherited and sporadic cases of malignant melanoma, the most deadly form of skin cancer.

Bacterial genes tell the tale of an outbreak's evolution
Researchers have retraced the evolution of an unusual bacterial infection as it spread among cystic fibrosis patients by sequencing scores of samples collected during the outbreak, since contained.

Climate policies can help resolve energy security and air pollution challenges
Policies to protect the global climate and limit global temperature rise offer the most effective entry point for achieving energy sustainability, reducing air pollution, and improving energy security, according to an article published in the latest issue of Nature Climate Change.

Combination therapy shows potent tumor growth inhibition in preclinical studies
Combining the investigational agents REGN910 and aflibercept yielded statistically significant improvements in antitumor effects in animal models compared with either agent alone, according to results presented at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, held Nov.

Future obesity may be predicted at 3.5 years of age
Researchers can predict which children are most likely to become obese by examining their mothers' behavior around their birth, according to a recent University of Montreal study published in the Archives of Pediatric and Adolescent Medicine.

New fund for young developing world innovators to tackle deadly global health conditions
Supporting the pursuit of bold, creative health-related innovations in developing countries is the goal of a new $18 million fund announced today by Grand Challenges Canada.

New way to target - and kill - proliferating tumors
Researchers at the University of California, San Diego School of Medicine and the UC San Diego Moores Cancer Center have identified a new drug discovery approach enabling the destruction of the most highly proliferative tumors.

Rising air pollution worsens drought, flooding, UMD-led study shows
Increases in air pollution and other particulate matter in the atmosphere can strongly affect cloud development in ways that reduce precipitation in dry regions or seasons, while increasing rain, snowfall and the intensity of severe storms in wet regions or seasons, says a new study by a University of Maryland-led team of researchers.

Signaling pathway linked to inflammatory breast cancer may drive disease metastasis
Amplification of anaplastic lymphoma kinase, which has been reported in other cancers such as non-small cell lung cancers, may be a primary driver of the rapid metastasis that patients with inflammatory breast cancer experience.

Wearable defibrillator can prevent death in people with arrhythmias
A wearable defibrillator can prevent sudden death in people with dangerous heart arrhythmias, according to research presented at the American Heart Association's Scientific Sessions 2011.

Benefit of novel drug in breast cancer seen in blood within weeks
Clinical benefit from use of a novel histone deacetylase inhibitor drug may be determined by examining blood cells days after a patient receives treatment.

Few doctors follow sudden cardiac death screening guidelines for athletes
According to a state survey, fewer than 6 percent of doctors fully follow national guidelines for assessing sudden cardiac death risk during high school sports physicals, researchers said at the American Heart Association's Scientific Sessions 2011.

Low vitamin C levels may raise heart failure patients' risk
Low levels of vitamin C were associated with higher levels of high sensitivity C-Reactive protein and shorter intervals without major cardiac issues or death for heart failure patients, in research presented at the American Heart Association's Scientific Sessions 2011.

Kraken set to deliver 2 billionth CPU hour, sustains 96 percent utilization
The Cray XT5 reinforces its ability to meet the needs of users across a broad range of scientific domains.

Anti-clotting drug lowers risks in acute coronary syndrome treatment
An oral anti-clotting drug, when added to standard medical treatment for acute coronary syndrome, lowered the risk of death, heart attack or stroke an average of 16 percent, according to research presented at the American Heart Association's Scientific Sessions.

Ultrathin flexible brain implant offers unique look at seizures in NIH-funded research
Researchers funded by the National Institutes of Health have developed a flexible brain implant that could one day be used to treat epileptic seizures.

Novel monoclonal antibody offers potential treatment for tumors resistant to VEGF therapy
Despite the widespread use of current antiangiogenic cancer therapies, many tumors escape this blockade, which is designed to shut down growth of new blood vessels that feed tumors and spread cancer cells.
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