Brightsurf Science News & Current Events

January 31, 2020
Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class...
Intratumoral injection of SD-101 induces significant anti-tumor immunity in preclinical and clinical studies, especially when combined with PD-1 blockade.

Virtual crossmatching improves quality of life for kidney transplant patients
Virtual antibody crossmatching is a safe and efficient way of selecting kidney transplant recipients.

Anti-carcinoembryonic antigen-related cell adhesion molecule antibody for fluorescence visualization
Oncotarget Volume 11, Issue 4: The research team's aim was to investigate mAb 6G5j binding characteristics and to validate fluorescence targeting of colorectal tumors and metastases in patient derived orthotopic xenograft models with fluorescently labeled 6G5j.

Do less and get stronger: Science proves you can lift less with better results
Weightlifters could do less and get stronger by changing the amount they lift each session, according to new research.

Phantom genes keep diabetes at bay
Until now, the purpose of a specific of what we might call 'phantom genes' was largely unknown.

Pinpointing rare disease mutations
Scientists have compiled mouse and human cell knockout data to categorise genes based on how essential they are for survival and organism development.

How the immune system becomes blind to cancer cells
Researchers have described the activation of a key protein used by tumor cells to stop the body's immune response.

Updated shark tagging atlas provides more than 50 years of tagging and recapture data
A citizen science program more than 50 years old has shed new light on the movements and distribution patterns of 35 species of Atlantic sharks.

Get easily out of breath? It may be because you were small at birth, study finds
Babies born with low birth weights are more likely to have poor cardiorespiratory fitness later in life than their normal-weight peers.

Institut Pasteur sequences the whole genome of the Wuhan coronavirus, 2019-nCoV
On January 24, 2020, the French Ministry of Health confirmed the first three cases of patients affected by the Wuhan coronavirus.

Migraine rats, medical facts
Migraine mechanisms are still far from being fully understood. Escalating data from animal models are 'fact-checking' the neurophysiological and behavioral correlates of the migraine experience in humans, and how they may be affected by current anti-migraine drugs or might translate into new therapies.

Effect of state law allowing pharmacists to dispense naloxone without prescription
Naloxone is a medication used to reverse an opioid overdose, and this study looked at how an Ohio law that allowed pharmacists to dispense naloxone without a prescription was associated with dispensing rates.

New guideline aims to transform evaluation and care of children and adolescents with ADHD
The Journal of Developmental & Behavioral Pediatrics is releasing a groundbreaking guideline for the diagnosis and care of attention-deficit/hyperactivity disorders in children and youth in a supplement to its February 2020 issue.

Study: Tasting no-calorie sweetener may affect insulin response on glucose tolerance test
New research led by University of Illinois professor of food science and human nutrition M.

Lung cancer screening decision aid delivered through tobacco quitlines improves informed decision-making
Researchers from The University of Texas MD Anderson Cancer Center have shown that a decision aid delivered through tobacco quitlines effectively reaches a screening-eligible population and results in informed decisions about lung cancer screening.

Study finds first major discovery in hydroformylation in 50 years
In a new study published in Science, an AAAS publication, LSU chemistry professor emeritus George Stanley and fellow LSU researchers from the Department of Chemistry and the Department of Biological Sciences discovered a new cationic cobalt bisphosphine hydroformylation catalyst system that is highly active and extremely robust.

Could resetting our internal clocks help control diabetes?
The circadian clock system allows the organisms to adjust to periodical changes of geophysical time.

Simplifying simple sequence repeats
Simple sequence repeats (or microsatellites) continue to be widely used in a variety of biological disciplines, including forensics, paternity testing, population genetics, genetic mapping, and phylogeography.

UC study shows dramatic increase in naloxone dispensing in Ohio
A new study by pharmacy researchers at the University of Cincinnati shows a 2,328% increase in the number of naloxone prescriptions dispensed in Ohio.

Yale researchers identify protein that could help neutralize deadly bite of the tsetse fly
Researchers at the Yale School of Public Health have identified a family of surface proteins that could be promising new vaccine candidates to help control African sleeping sickness, a devastating disease passed on by the bite of infected tsetse flies.

Zoo improvements should benefit all animals
Zoo improvements should benefit all animals and include a wide range of 'enrichment' techniques, researchers say.

Researchers identify possible new combination treatment for advanced melanoma
Immunotherapy drug in combination with an infusion of anti-tumor immune cells may produce a stronger immune response that could help fight advanced melanoma.

Safe potassium-ion batteries
Australian scientists have developed a nonflammable electrolyte for potassium and potassium-ion batteries, for applications in next-generation energy-storage systems beyond lithium technology.

Characterization of unique PMEPA1 gene splice variants (isoforms d and e) from RNA Seq profiling pro
In addition to 4 reported PMEPA1 isoforms, one novel isoform PMEPA1-e was identified with RNA Seq analysis of hormone-responsive VCa P, LNCa P cells and human prostate cancer samples from The Cancer Genome Atlas dataset.

Highly active HIV antibody restricts development of viral resistance
A research team led by Univ.-Prof. Dr. Florian Klein of the Institute of Virology of the University Hospital Cologne and the German Center for Infection Research (DZIF) has identified a new highly active antibody targeting HIV.

The most human algorithm
A team from the research group SEES:lab of the Department of Chemical Engineering of the Universitat Rovira I Virgili and ICREA has made a breakthrough with the development of a new algorithm that makes more accurate predictions and generates mathematical models that also make it possible to understand these predictions.

Exotic new topological state discovered in Dirac semimetals
An international team of scientists has discovered an exotic new form of topological state in a large class of 3D semi-metallic crystals called Dirac semimetals.

DNA extracted in museum samples can reveal genetic secrets
DNA in preserved museum specimens can allow scientists to explore the history of species and humanities impact on the ecosystem, but samples are typically preserved in formaldehyde which can damage DNA and make very difficult to recover.

Religiousness linked to improved quality of life for people with HIV
Adults living with HIV in Washington, D.C., were more likely to feel higher levels of emotional and physical well-being if they attended religious services regularly, prayed daily, felt 'God's presence,' and self-identified as religious or spiritual, according to research published online Jan.

Jump in employment seen among Medicaid expansion enrollees, especially the most vulnerable
Getting covered by health insurance may have a major impact on a low-income person's ability to get a job or enroll in school, according to a new study that gives the first direct look at the relationship between the two.

How supercomputers are helping us link quantum entanglement to cold coffee
Theoretical physicists from Trinity College Dublin have found a deep link between one of the most striking features of quantum mechanics -- quantum entanglement -- and thermalisation, which is the process in which something comes into thermal equilibrium with its surroundings.

Fewer scars in the central nervous system
Researchers have discovered the influence of the coagulation factor fibrinogen on the damaged brain.

The Lancet: Modelling study estimates spread of 2019 novel coronavirus
New modelling research, published in The Lancet, estimates that up to 75,800 individuals in the Chinese city of Wuhan may have been infected with 2019 novel coronavirus (2019-nCoV) as of Jan.

Inherited DNA-repair gene mutations in African American men with prostate cancer
Oncotarget Volume 11, Issue 4: Pathogenic or likely pathogenic alterations in these 14 DNA repair genes were less likely to be detected in African Americans as compared to Caucasians.

Horseback riding combined with cognitive exercises can help children with ADHD and autism spectrum
A combination of therapeutic horseback riding and brain-building exercises can help children with neurodevelopmental disorders improve their motor skills, according to a new study.

Do state regulations affect adult use of e-cigarettes?
National data from 895,000 adults were used to examine how state regulations regarding electronic cigarettes were associated with their use among US adults.

Spike in colorectal cancer from age 49 to 50 suggests many undiagnosed before screenings
A year-by-year age analysis of colorectal cancer rates among US adults finds a significant increase in new diagnoses from ages 49 to 50, indicating that many latent cases of the disease are likely going undiagnosed until routine screenings begin at 50.

Got slime? Using regenerative biology to restore mucus production
Mucus production is essential to health, and an imbalance can be life-threatening.

New research highlights how plants are slowing global warming
A new paper reveals how humans are helping to increase the Earth's plant and tree cover, which absorbs carbon from the atmosphere and cools our planet.

Congenital heart disease more deadly in low-income countries
Even though mortality from congenital heart disease (CHD) has declined over the last three decades as diagnosis and treatments have advanced, a new study shows that the chances for a child to survive a CHD diagnosis significantly differs based on the country where he or she is born.

Cleveland clinic study clarifies genetic autism risk in PTEN patients
Cleveland Clinic researchers have identified for the first time an explanation of why patients with identical PTEN mutations often have vastly different clinical presentations.

Ultra-high energy events key to study of ghost particles
Physicists propose a new way to leverage data from ultra-high energy neutrinos from large neutrino telescopes such as the IceCube Neutrino Observatory in Antarctica.

First view of hydrogen at the metal-to-metal hydride interface
University of Groningen physicists have visualized hydrogen at the titanium/titanium hydride interface using a transmission electron microscope.

Young people putting music to the crisis: the role of music as a political expression
On February 1, 2020, the journal Young is publishing a special issue on youth, music and crisis involving Mònica Figueras, José Sánchez-García and Carlos Feixa, researchers from the Youth, Society and Communication Research Group ( at the Department of Communication.

Not-so-dirty birds? Not enough evidence to link wild birds to food-borne illness
Despite the perception that wild birds in farm fields can cause food-borne illness, a WSU study has found little evidence linking birds to E. coli, Salmonella and Campylobacter outbreaks.

Toward a portable concussion detector that relies on an infrared laser
With no way to reliably tell whether an athlete has a concussion, many may be playing with an undiagnosed injury.

Researchers describe unique genetic identity of primordial lung progenitors
For the first time, researchers describe the genetic program behind primordial lung progenitors -- embryonic cells that give rise to all the cells that form the lining of the respiratory system after birth.

The first potentially invasive species to reach the Antarctica on drifting marine algae
Drifting algae in the Austral Ocean can bring invasive species to the Antarctic coasts, according to a study published in the journal Scientific Reports.

Choice of anesthesia may affect breast cancer metastases
A new study led by Stony Brook University Cancer Center researchers to be published in Nature Communications suggests that the choice of anesthesia may change the metastatic process of breast cancer by affecting the cytokine and microenvironment.

The scent of a rose improves learning during sleep
Fragrances like rose scent can easily help to better consolidate memory during sleep, as researchers at the University of Freiburg -- Medical Center show / Experiment with school classes confirms and simplifies a highly regarded study.

Institut Pasteur isolates strains of coronavirus 2019-nCoV detected in France
As well as sequencing the whole genome of coronavirus 2019-nCoV, the Institut Pasteur continued to work on the samples taken from the first confirmed cases.

Global science team on red alert as Arctic lands grow greener
New research techniques are being adopted by scientists tackling the most visible impact of climate change - the so-called greening of Arctic regions.

Mutation's role in blood cancers revealed by ideal team-up
Researchers from CSHL and MSKCC have determined that a mutation affecting the important process of RNA splicing can manipulate the 'quality control' in your cell.

Hot pots helped ancient Siberian hunters survive the Ice Age
A new study shows that ancient Siberian hunters created heat resistant pots so that they could cook hot meals - surviving the harshest seasons of the ice age by extracting nutritious bone grease and marrow from meat.

Seeking better guidelines for inventorying greenhouse gas emissions
Governments around the world are striving to hit reduction targets using Intergovernmental Panel on Climate Change (IPCC) guidelines to limit global warming.

Accelerating chemical reactions without direct contact with a catalyst
Northwestern University researchers demonstrate a chemical reaction produced through an intermediary created by a separate chemical reaction, findings that could impact environmental remediation and fuel production.

Army research may improve stroke, TBI treatment
New Army research provides a better understanding of the swelling that occurs in the brain during a stroke, which could contribute to new treatment strategies for stroke patients and have potential implications for traumatic brain injuries.

Exploring strangeness and the primordial Universe
Within quark-gluon plasma, strange quarks are readily produced through collisions between gluons.

Rates of new colorectal cancer cases as people turn 50, historically begin screening
Cancer registries representing about 28% of the US population were used to examine how new cases of colorectal cancer increased from age 49 to 50, the age when many people of average risk for the disease historically began screening, although screening age recommendations vary.

Biophysics: Orientation of protein patterns
During embryogenesis in the nematode Caenorhabditis elegans, the first cell division occurs transverse to the long axis of the fertilized egg.

Exploring the school-age social, emotional, and behavioral health landscape
Through a four-year federally funded project, UConn researchers looked at school districts across the country to better understand how social, emotional, and behavioral health screening tools are being employed, and what factors influence their use.

Discovery takes pressure off blood measurements
Monash University researchers are developing a revolutionary, portable blood pressure monitoring device that provides data continuously to patients.

Efficient cryopreservation of genetically modified rat spermatozoa
Researchers at Kumamoto University have developed a new technique to improve the efficiency of rat sperm cryopreservation, a process that is usually extremely difficult.

Novel coronavirus receptors show similarities to SARS-CoV, according to new analysis
The recent emergence of Wuhan coronavirus (2019-nCoV) has put the world on high alert for transcontinental transmission, reminiscent of the outbreak of SARS -- also a coronavirus -- in 2002-2003.

New research looks at type 1 diabetes and changes in the environment
Studies have shown a rapid increase in new cases of type 1 diabetes worldwide. is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to