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Endothelial cell metabolism: parallels and divergences with cancer cell metabolism | Paperback

by Almere Press (Author)


List Price: $380.00  
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Binding:  Paperback
Publisher:  CreateSpace Independent Publishing Platform
Page Count:  48 Pages
Publication Date:  July 14, 2016



EDITORIAL REVIEWS


Product Description
The stromal vasculature in tumors is a vital conduit of nutrients and oxygen for cancer cells. To date, the vast majority of studies have focused on unraveling the genetic basis of vessel sprouting (also termed angiogenesis). In contrast to the widely studied changes in cancer cell metabolism, insight in the metabolic regulation of angiogenesis is only just emerging. These studies show that metabolic pathways in endothelial cells (ECs) importantly regulate angiogenesis in conjunction with genetic signals. In this review, we will highlight these emerging insights in EC metabolism and discuss them in perspective of cancer cell metabolism. While it is generally assumed that cancer cells have unique metabolic adaptations, not shared by healthy non-transformed cells, we will discuss parallels and highlight differences between endothelial and cancer cell metabolism and consider possible novel therapeutic opportunities arising from targeting both cancer and endothelial cells. Proceeds from the sale of this book go to support an elderly disabled person.

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