Orphan is about the struggle to save the lives of children who, because of an unlucky roll of the genetic dice, are born with any one of several thousand rare genetic disorders. Many are burdened with diseases that carry mysterious names, some of which you can read about for the first time in this book, along with compelling stories about the physicians, scientists, and parents who have taken them on. The diseases include phenylketonuria, sickle cell anemia, dystrophic epidermolysis bullosa, X-linked hypohidrotic ectodermal dysplasia, and Friedreich's ataxia-just a few of the more than 1000 genetic disorders that are well-described and many more that are not. Many manifest in infancy. Some show up in mid-childhood, others later in childhood, and still others among adults. They touch almost every extended family. Orphan is more than a book about disease and research--it gives voice to thousands of people who, all too often, have endured terrible illnesses, bravely faced arduous clinical trials, and, sometimes, have gained victories, almost always in silence. This book recounts extraordinary breakthroughs and hopes for the future. Many of the disorders that will end our lives are in some part genetically influenced. We really are all orphans, and this book is for all of us.
|A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution|
by Jennifer A. Doudna (Author), Samuel H. Sternberg (Author)
A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new...
|The Gene: An Intimate History|
by Siddhartha Mukherjee (Author)
THE #1 NEW YORK TIMES BESTSELLER
A New York Times Notable Book
A Washington Post and Seattle Times Best Book of the Year
From the Pulitzer Prize-winning, bestselling author of The Emperor of All Maladies—a magnificent history of the gene and a response to the defining question of the future: What becomes of being human when we learn to “read” and “write” our own genetic information?
Siddhartha Mukherjee has a...
|The Cure: How a Father Raised $100 Million--and Bucked the Medical Establishment--in a Quest to Save His Children|
by Geeta Anand (Author)
“Amazing….Explores human courage under the most trying circumstances.” —New York Post “An inspirational story about business, medical science, and one father’s refusal to give up hope.” —Boston Globe The book that inspired the movie, Extraordinary Measures, starring Harrison Ford, Brendan Fraser, and Keri Russell, The Cure by Pulitzer Prize-winning journalist Geeta Anand is the remarkable...
|Vaccinated: One Man's Quest to Defeat the World's Deadliest Diseases|
by Paul A., M.D. Offit (Author)
His goal—to prevent every disease that commonly attacked children—was unattainable. But Maurice Hilleman came close.
Maurice Hilleman is the father of modern vaccines. Chief among his accomplishments are nine vaccines that practically every child gets, rendering formerly deadly diseases—including mumps, rubella, and measles—nearly forgotten. Author Paul A. Offit’s rich and lively narrative details Hilleman’s research and experiences as the basis for a larger exploration...
|The Death of Cancer: After Fifty Years on the Front Lines of Medicine, a Pioneering Oncologist Reveals Why the War on Cancer Is Winnable--and How We Can Get There|
by Vincent T. DeVita Jr. M.D. (Author), Elizabeth DeVita-Raeburn (Author)
Cancer touches everybody’s life in one way or another. But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical...
|Bad Faith: When Religious Belief Undermines Modern Medicine|
by Paul Offit (Author)
In recent years, there have been major outbreaks of whooping cough among children in California, mumps in New York, and measles in Ohio's Amish country—despite the fact that these are all vaccine-preventable diseases. Although America is the most medically advanced place in the world, many people disregard modern medicine in favor of using their faith to fight life threatening illnesses. Christian Scientists pray for healing instead of going to the doctor, Jehovah's Witnesses refuse blood...
|The Philadelphia Chromosome: A Mutant Gene and the Quest to Cure Cancer at the Genetic Level|
by Jessica Wapner (Author), Robert A. Weinberg PhD (Foreword)
A Wall Street Journal 10 Best Nonfiction Book of the Year
“Among a small cluster of very good recent books on cancer.” —The New York Times
Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers...
|Carrier: Untangling the Danger in My DNA|
by Bonnie J Rough (Author)
When Bonnie J. Rough receives the test results that confirm she is a carrier of the genetic condition hypohidrotic ectodermal dysplasia, or H.E.D., it propels her on a journey deep into her family’s past in the American West.
At first glance, H.E.D. seems only to be a superficial condition: a peculiar facial bone structure, sparse hair, few teeth, and an inability to sweat. But a closer look reveals the source of a lifetime of infections, breathing problems, and drug dependency for...
|Human Genes and Genomes: Science, Health, Society|
by Leon E. Rosenberg (Author), Diane Drobnis Rosenberg (Author)
In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences. The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor’s office, in the courtroom and even in social relationships. In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the...
|One in a Billion: The Story of Nic Volker and the Dawn of Genomic Medicine|
by Mark Johnson (Author), Kathleen Gallagher (Author)
The breathtaking story of a young boy with a never-before-seen disease, and the doctors who take a bold step into the future of medicine to save him—based on the authors’ Pulitzer Prize–winning reporting.
In this landmark medical narrative, in the tradition of The Immortal Life of Henrietta Lacks and The Spirit Catches You and You Fall Down, Pulitzer Prize–winning journalists Mark Johnson and Kathleen Gallagher chronicle the story of Nic Volker, the Wisconsin boy at...