Nav: Home

The emergence of a new dopamine hypothesis of schizophrenia

January 02, 2017

Philadelphia, PA, January 2, 2017 - Biological Psychiatry presents a special issue, "The Dopamine Hypothesis of Schizophrenia", dedicated to recent advances in understanding the role of dopamine signaling in schizophrenia. The issue, organized by Anissa Abi-Dargham, MD, of Stony Brook University, New York, and a deputy editor of Biological Psychiatry, compiles seven reviews that summarize current knowledge and provide new insights.

The dopamine hypothesis of schizophrenia has been revised numerous times since clinical observations first implicated the neurotransmitter decades ago, and dopamine alterations are some of the most well-established research findings in schizophrenia.

"Unlike any other neurobiological hypothesis of the disease, the dopamine hypothesis has confirmatory evidence from in vivo studies in patients and from pharmacological therapies," Abi-Dargham said. Despite this, researchers have yet to fully understand when and how dopamine alterations arise in the brain, or their relationship with the diversity of symptoms in the disease.

"This issue highlights the complexity of the findings in patients with the disorder, and raises the possibility that dopamine alterations can lead to a vast array of consequences on the circuitry, on learning and behavior that can explain the vast array of symptom clusters," Abi-Dargham said.

The body of work collated in the issue ranges from human studies to animal models. Neuroimaging, genetic, and molecular imaging studies have helped elucidate the regional differences of dopamine dysfunction throughout the brain, and detailed timing of dopamine alterations in relation to development, symptom onset, and other neurobiological alterations in the disease. Animal models have allowed researchers to further refine and test the hypothesis, and explore mechanisms behind the dysregulation.

Clarifying the role of dopamine signaling in schizophrenia also shows promise for improving treatment for the disorder. "We include here some examples of exciting new targeted therapeutic approaches that are currently under development," Abi-Dargham said.

Although the dopamine system has long been pegged as the culprit for psychotic symptoms in schizophrenia, a review in this issue using a computational approach to integrate experimental findings provides an explanation for how dopamine dysfunction could lead to the range of symptoms present in the disorder.

The therapeutic approaches proposed in the issue aim to find new strategies for targeting dopamine signaling to improve the limitations of current antipsychotic drugs, which only treat psychotic symptoms and come with a host of major side effects, by targeting new pathways and tapping into dopamine's role in other regions of the brain.
-end-
Notes for editors

The special issue is "Dopamine Hypothesis of Schizophrenia," Biological Psychiatry, volume 81, issue 1 (2017), published by Elsevier.

Studies included in this issue are available to credentialed journalists upon request; please contact Elsevier's Newsroom at newsroom@elsevier.com or +31 20 485 2492.

About Biological Psychiatry

Biological Psychiatry is the official journal of the Society of Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal publishes both basic and clinical contributions from all disciplines and research areas relevant to the pathophysiology and treatment of major psychiatric disorders.

The journal publishes novel results of original research which represent an important new lead or significant impact on the field, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. Reviews and commentaries that focus on topics of current research and interest are also encouraged.

Biological Psychiatry is one of the most selective and highly cited journals in the field of psychiatric neuroscience. It is ranked 5th out of 140 Psychiatry titles and 11th out of 256 Neurosciences titles in the Journal Citations Reports® published by Thomson Reuters. The 2015 Impact Factor score for Biological Psychiatry is 11.212.

About Elsevier

Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions -- among them ScienceDirect, Scopus, Research Intelligence and ClinicalKey -- and publishes over 2,500 journals, including The Lancet and Cell, and more than 35,000 book titles, including a number of iconic reference works. Elsevier is part of RELX Group, a world-leading provider of information and analytics for professional and business customers across industries. http://www.elsevier.com

Elsevier

Related Schizophrenia Articles:

First physiological test for schizophrenia and depression
Researchers have found a new way of using proteins in nerve cells to identify people with depression and schizophrenia.
The emergence of a new dopamine hypothesis of schizophrenia
Biological Psychiatry presents a special issue, 'The Dopamine Hypothesis of Schizophrenia,' dedicated to recent advances in understanding the role of dopamine signaling in schizophrenia.
Progress in refining the genetic causes of schizophrenia
An international study led by the University of Exeter Medical School has made advances in understanding the ways in which genetic risk factors alter gene function in schizophrenia.
Exercise can tackle symptoms of schizophrenia
Aerobic exercise can significantly help people coping with the long-term mental health condition schizophrenia, according to a new study from University of Manchester researchers.
In search of neurobiological factors for schizophrenia
It is impossible to predict the onset of schizophrenic psychosis.
A comparison between quetiapine and aripiprazole for treatment of schizophrenia
Schizophrenia is a common cause of incapacity and is ranked as the third most disabling illness subsequent to dementia and quadriplegia.
Four new genetic diseases defined within schizophrenia
Changes in key genes define four previously unknown conditions within schizophrenia, according to a study led by researchers from NYU Langone Medical Center published online April 28 in EBioMedicine, a Lancet journal.
Decrypting a collagen's role in schizophrenia
A small peptide generated from a collagen protein may protect the brain from schizophrenia by promoting the formation of neuronal synapses, according to a paper published in The Journal of Cell Biology.
Two in 5 individuals with schizophrenia have attempted suicide
A new study by the University of Toronto (U of T), released today, found that those with schizophrenia who'd been physically abused during childhood were five times more likely to have attempted suicide.
'Schizophrenia' does not exist, argues expert
The term 'schizophrenia,' with its connotation of hopeless chronic brain disease, should be dropped and replaced with something like 'psychosis spectrum syndrome,' argues a professor of psychiatry in The BMJ today.

Related Schizophrenia Reading:

Surviving Schizophrenia, 6th Edition: A Family Manual
by E. Fuller Torrey (Author)

The Center Cannot Hold: My Journey Through Madness
by Elyn R. Saks (Author)

I Am Not Sick, I Don't Need Help! How to Help Someone with Mental Illness Accept Treatment. 10th Anniversary Edition.
by Xavier Amador (Author)

The Complete Family Guide to Schizophrenia: Helping Your Loved One Get the Most Out of Life
by Kim T. Mueser (Author), Susan Gingerich (Author)

Schizophrenia: Cognitive Theory, Research, and Therapy
by Aaron T. Beck (Author), Neil A. Rector (Author), Neal Stolar (Author), Paul Grant (Author)

Schizophrenia: Understanding Symptoms Diagnosis & Treatment
by Anthony Wilkenson (Author)

When the Sun Bursts: The Enigma of Schizophrenia
by Christopher Bollas (Author)

Cognitive-Behavioral Social Skills Training for Schizophrenia: A Practical Treatment Guide
by Eric L. Granholm (Author), John R. McQuaid (Author), Jason L. Holden (Author), Kim T. Mueser (Foreword), Alan S. Bellack (Foreword)

Schizophrenia: A Blueprint for Recovery
by Milt Greek (Author)

The Disordered Mind: What Unusual Brains Tell Us About Ourselves
by Eric R. Kandel (Author)

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Hacking The Law
We have a vision of justice as blind, impartial, and fair — but in reality, the law often fails those who need it most. This hour, TED speakers explore radical ways to change the legal system. Guests include lawyer and social justice advocate Robin Steinberg, animal rights lawyer Steven Wise, political activist Brett Hennig, and lawyer and social entrepreneur Vivek Maru.
Now Playing: Science for the People

#495 Earth Science in Space
Some worlds are made of sand. Some are made of water. Some are even made of salt. In science fiction and fantasy, planet can be made of whatever you want. But what does that mean for how the planets themselves work? When in doubt, throw an asteroid at it. This is a live show recorded at the 2018 Dragon Con in Atlanta Georgia. Featuring Travor Valle, Mika McKinnon, David Moscato, Scott Harris, and moderated by our own Bethany Brookshire. Note: The sound isn't as good as we'd hoped but we love the guests and the conversation and we wanted to...