Nav: Home

Lower risk for malignant melanoma after bariatric surgery

January 02, 2020

Bariatric surgery is associated with a distinct reduction in skin-cancer risk, a study shows. This finding can be described as a key piece of evidence that substantiates the connection between weight loss and malignant skin cancer.

"This provides further evidence for a connection between obesity and malignant skin cancer, and for the view that we should regard obesity as a risk factor for these forms of cancer," says Magdalena Taube, the first author behind the study and a researcher in molecular and clinical medicine at Sahlgrenska Academy, University of Gothenburg, Sweden.

That obesity is a risk factor for several types of cancer is well known. The same applies to the fact that people's risk level can be lowered by means of an intentional weight reduction. However, the evidence for a connection between obesity and weight loss on the one hand and, in particular, malignant skin cancer on the other has been limited to date.

The current study, published in JAMA Dermatology, used data from what is known as the SOS (Swedish Obese Subjects) study, which is led and coordinated from the University of Gothenburg. Other data sources included the Swedish Cancer Register kept by the Swedish National Board of Health and Welfare.

The researchers studied a group of 2,007 people who underwent bariatric surgery, and compared them with a control group of 2,040 individuals. The latter also had severe obesity but were not given bariatric surgery. Otherwise, in terms of gender, age, body composition, risk factors for cardiovascular disease, and psychosocial variables, the groups were comparable.

The surgery group included 23 individuals who developed malignant skin cancer, i.e. squamous cell carcinoma or malignant melanoma, in parallel with marked weight loss. The corresponding figure for such cancer cases in the control group was 45, while this group remained at the severe obesity level. The median follow-up period was just over 18 years.

The largest difference related to malignant melanoma: 12 people in the surgery group were affected, against 29 in the control group. The results thus show a 57 percent fall in risk for malignant melanoma in the group who lost weight after bariatric surgery. The corresponding risk decrease for both cancer forms combined was 42 percent.

"In these contexts, it's a clear and striking change. And that's why it's so interesting," Taube says.

The findings support the idea that obesity is a risk factor for malignant skin cancer, including melanoma, and indicate that weight loss in individuals with obesity may reduce their risk for this severe form of cancer.

"We can say this with certainty now, thanks to our having an extremely well documented and described population that we've been able to monitor for a long time, and in which we can see very clearly what happens when a major, lasting weight loss takes place," Magdalena Taube concludes.
-end-
Title: Association of Bariatric Surgery With Skin Cancer Incidence in Adults With Obesity: A Nonrandomized Controlled Trial; https://jamanetwork.com/journals/jamadermatology/article-abstract/2753269

University of Gothenburg

Related Obesity Articles:

Changing the debate around obesity
The UK's National Health Service (NHS) needs to do more to address the ingrained stigma and discrimination faced by people with obesity, says a leading health psychologist.
Study links longer exposure to obesity and earlier development of obesity to increased risk of type 2 diabetes
Cumulative exposure to obesity could be at least as important as actually being obese in terms of risk of developing type 2 diabetes (T2D), concludes new research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]).
How much do obesity and addictions overlap?
A large analysis of personality studies has found that people with obesity behave somewhat like people with addictions to alcohol or drugs.
Should obesity be recognized as a disease?
With obesity now affecting almost a third (29%) of the population in England, and expected to rise to 35% by 2030, should we now recognize it as a disease?
Is obesity associated with risk of pediatric MS?
A single-center study of 453 children in Germany with multiple sclerosis (MS) investigated the association of obesity with pediatric MS risk and with the response of first-line therapy in children with MS.
Women with obesity prior to conception are more likely to have children with obesity
A systematic review and meta-analysis identified significantly increased odds of child obesity when mothers have obesity before conception, according to a study published June 11, 2019 in the open-access journal PLOS Medicine by Nicola Heslehurst of Newcastle University in the UK, and colleagues.
Obesity medicine association announces major updates to its adult obesity algorithm
The Obesity Medicine Association (OMA) announced the immediate availability of the 2019 OMA Adult Obesity Algorithm, with new information for clinicians including the relationship between Obesity and Cardiovascular Disease, Diabetes Mellitus, Dyslipidemia, and Cancer; information on investigational Anti-Obesity Pharmacotherapy; treatments for Lipodystrophy; and Pharmacokinetics and Obesity.
Systematic review shows risk of a child developing overweight or obesity is more than trebled by maternal obesity prior to pregnancy
New research presented at this year's European Congress on Obesity (ECO) in Glasgow, Scotland (April 28- May 1) reveals that the risk of a child becoming overweight or obese is more than trebled by maternal obesity prior to getting pregnant.
Eating later in the day may be associated with obesity
Eating later in the day may contribute to weight gain, according to a new study to be presented Saturday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.
How obesity affects vitamin D metabolism
A new Journal of Bone and Mineral Research study confirms that vitamin D supplementation is less effective in the presence of obesity, and it uncovers a biological mechanism to explain this observation.
More Obesity News and Obesity Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Making Amends
What makes a true apology? What does it mean to make amends for past mistakes? This hour, TED speakers explore how repairing the wrongs of the past is the first step toward healing for the future. Guests include historian and preservationist Brent Leggs, law professor Martha Minow, librarian Dawn Wacek, and playwright V (formerly Eve Ensler).
Now Playing: Science for the People

#566 Is Your Gut Leaking?
This week we're busting the human gut wide open with Dr. Alessio Fasano from the Center for Celiac Research and Treatment at Massachusetts General Hospital. Join host Anika Hazra for our discussion separating fact from fiction on the controversial topic of leaky gut syndrome. We cover everything from what causes a leaky gut to interpreting the results of a gut microbiome test! Related links: Center for Celiac Research and Treatment website and their YouTube channel
Now Playing: Radiolab

The Flag and the Fury
How do you actually make change in the world? For 126 years, Mississippi has had the Confederate battle flag on their state flag, and they were the last state in the nation where that emblem remained "officially" flying.  A few days ago, that flag came down. A few days before that, it coming down would have seemed impossible. We dive into the story behind this de-flagging: a journey involving a clash of histories, designs, families, and even cheerleading. This show is a collaboration with OSM Audio. Kiese Laymon's memoir Heavy is here. And the Hospitality Flag webpage is here.