Hydroxychloroquine blood levels predict clotting risk in patients with lupus

January 06, 2021

The antimalarial drug hydroxychloroquine is frequently prescribed to treat symptoms of the autoimmune disease lupus. In addition to decreasing disease flares, the drug can also prevent blood clots, which are a major problem in individuals with lupus. A new study in Arthritis & Rheumatology shows that monitoring patients' blood levels of hydroxychloroquine can predict their clotting risk.

In 739 patients, clotting occurred in 38 patients (5.1%). Average hydroxychloroquine blood levels were lower in patients who developed clots, and clotting rates were reduced by 12% for every 200 ng/mL increase in the most recent hydroxychloroquine blood level.

The finding may help clinicians determine the optimal dosing of hydroxychloroquine in patients with lupus.

"Hydroxychloroquine blood levels can be used to monitor adherence, benefits, and risks in lupus," said lead author Michelle Petri, MD, MPH, of the Johns Hopkins University School of Medicine.
-end-


Wiley

Related Lupus Articles from Brightsurf:

Systemic lupus erythematosus (SLE)
If renal remission is achieved therapeutically in cases of lupus nephritis (LN), the 10-year survival rate increases significantly.

Race-specific lupus nephritis biomarkers
A University of Houston biomedical researcher has discovered a difference in urinary biomarker proteins of lupus nephritis in patients according to race.

Lupus patients who take their medications lower their diabetes risk
Patients with lupus who take their medications as prescribed have much lower odds of developing type 2 diabetes, a common complication of the disease, finds a new study from the University of British Columbia.

Nearly 1 in 3 patients with lupus use prescription opioids for pain
A new study finds nearly one in three adults with lupus use prescription opioids to manage pain, despite a lack of evidence that opioids are effective for reducing pain from rheumatic diseases.

Developing therapeutic strategies for pregnant women with lupus
A highly gender-biased disease, lupus afflicts females some nine times more than males.

Lupus antibody target identified
Researchers have identified a specific target of antibodies that are implicated in the neuropsychiatric symptoms of lupus, according to human research published in JNeurosci.

B cells off rails early in lupus
Emory scientists could discern that in people with SLE, signals driving expansion and activation are present at an earlier stage of B cell differentiation than previously appreciated.

Can adverse childhood experiences worsen lupus symptoms?
Adverse childhood experiences (ACEs) encompass traumas such as abuse, neglect, and household challenges.

Unlocking the female bias in lupus
The majority of lupus patients are female, and new findings from the University of Pennsylvania shed light on why.

How a single faulty gene can lead to lupus
IBS-AIM (Academy of Immunology and Microbiology) research team at Pohang University of Science and Technology (POSTECH) in South Korea has discovered the role of a key gene involved in the autoimmune disease systemic lupus erythematosus (SLE) or lupus for short.

Read More: Lupus News and Lupus Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.