World first multimodal biomicroscopic system enhances the accuracy of cancer treatment

January 07, 2018

A research team of Information and Communication Engineering at DGIST has developed the world's first multimodal biomicroscopic system to analyze the characteristics of tumors and to utilize them in tumor treatment technology research.

The research team has developed an imaging system that accurately analyzes the characteristics of tumors using the mechanical, chemical, and structural properties of colorectal cancer through the joint research with the research team of Eunjoo Kim from the Department of Nano & Energy Research.

Histopathologic examination of the removed tumor during surgery is an important procedure in the cancer surgical procedure. In particular, if a very small tumor is left on the operation site, it acts as a main cause of cancer recurrence or metastasis. Therefore, it is necessary to accurately analyze the removed tumor to find out whether cancer remains in the surgical site.

In order to analyze the present tumor, it is necessary to send a resected tumor to a pathologist to examine the specimen with a microscope to determine whether the resected cancer tissue is appropriately acquired and whether additional resection of the tissue during surgery is necessary. However, this process is time consuming and the results may be different depending on internal and external factors.

To overcome these disadvantages, optical microscope or ultrasonic wave were used. However, it was difficult to perform close inspection as they were unable to analyze the deep part of each tissue, or the resolution was poor.

Professor Hwang's research team has developed a converged biomicroscope based on high frequency ultrasound and optical spectroscopy to overcome the disadvantages of the imaging systems previously developed for tumor analysis.

Multimodal biomicroscopic system is capable to perform pathologic analysis simultaneously to detect the surface of resected tissues and tumors deep in the tissues during the cancer operation by converging optical multispectral imaging, high-frequency ultrasound B-mode, and high-frequency ultrasound radiation imaging techniques.

Tissue and tumor areas can be analyzed more precisely than a general fluorescence microscope as the optical spectroscopic imaging technique quantitatively analyzes the spectroscopic indicators emitted from the tissue surface. It is possible to detect deep tissue as well as tumor areas highly accurately with High Frequency Ultrasonic B-mode and High Frequency Ultrasonic Radiation Force Imaging Technique as they enable to image the impedance and elasticity of inside yin-yang the tissue at higher resolution than the existing ultrasonic imaging technique.

Through the experiment, the research team has proved that multimodal biomicroscopic system enables mechanical, chemical, and structural analysis of the tumor tissue from colon cancer patients at the high resolution from the surface to the deep of the tumor.

Professor Hwang said "We have developed a multimodal biomicroscopic system based on high-frequency ultrasound and optical spectroscopy for the first time in the world. It complements the disadvantages of the existing image analysis systems. We will conduct further studies to develop this system to the endoscope system which can be used for clinical diagnosis of cancer before the actual surgery."

The result of this study shows that the multimodal biomicroscopic system has the potential to qualitatively investigate the characteristics of incised tumors in vitro. The multimodal biomicroscopic system is expected to improve the efficiency and success rate of cancer surgery by increasing the accuracy of tumor removal surgery as well as shortening the operation time.
This study was published in the online edition of 'Scientific Reports,' sister journal of the international journal Nature, on December 13. The study was conducted as a 'basic research project in science and engineering' sponsored by the National Research Foundation.

For more information, please contact:

Associate Professor Jae Youn Hwang
Department of Information and Communication Engineering
Daegu Gyeongbuk Institute of Science and Technology (DGIST)

Associated Links

Research Paper on Journal of Scientific Reports
Multimodal Biomedical Imaging and System Laboratory

Journal Reference

Kim Jihun, Seo Anna, Kim Jun-young, et al., "A Multimodal Biomicroscopic System based on Highfrequency Acoustic Radiation Force Impulse and Multispectral Imaging Techniques for Tumor Characterization Ex vivo", Scientific Reports, December 2017

DGIST (Daegu Gyeongbuk Institute of Science and Technology)

Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to