Deep learning helps predicting occult peritoneal metastasis in stomach cancer

January 07, 2021

Stomach cancer, or gastric cancer, is a common gastrointestinal malignancy. Peritoneal metastasis occurs in a majority of patients with advanced stomach cancer and is considered as an aggressive disease with poor outcomes.

Patients with peritoneal metastasis are typically not eligible for curative surgery. Therefore, preoperative detection and diagnosis of peritoneal metastasis are critical to inform treatment decision-making and avoid unnecessary surgery.

A new study published in the JAMA Network Open on Jan. 5 shows that deep learning can help predicting the occult peritoneal metastasis in stomach cancer. It provides a novel and noninvasive approach for stomach cancer patients and may inform individualized surgical management of stomach cancer.

The study was conducted by Dr. XIE Yaoqin's group from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, Dr. LI Ruijiang from Stanford University, Dr. LI Guoxin from Nanfang Hospital, and Dr. ZHOU Zhiwei from Sun Yat-sen University Cancer Center.

The researchers developed a deep learning model called Peritoneal Metastasis Network (PMetNet) to predict clinically occult peritoneal metastasis using preoperative computed tomography (CT) images in patients with stomach cancer.

Dr. JIANG Yuming from Stanford University, one co-first author of this study, explained that the proposed deep learning model may serve as a reliable noninvasive tool for the early identification of patients with clinically occult peritoneal metastasis.

"It can also inform individualized preoperative treatment decision-making and may avoid unnecessary surgery and complications," said Ph.D. candidate LIANG Xiaokun from SIAT, the other co-first author.

Chinese Academy of Sciences Headquarters

Related Stomach Cancer Articles from Brightsurf:

Immunotherapy may work better in stomach cancer when combined with chemo, given earlier
Immunotherapy, often ineffective against stomach cancer, was more effective when combined with chemotherapy and given earlier, finds a new study in mice.

UArizona Health Sciences researchers find biomarker that can appear before stomach cancer
A microRNA that can be found in a blood sample may make it easier to detect gastric cancer and could lead to improved treatment for the disease and others like it that are resistant to common immunotherapies.

Study gauges specific site stomach cancer risks among ethnic groups
Non-white Americans, especially Asian Americans, are at disproportionately higher risk for gastric cancer compared to non-Hispanic white Americans.

Epstein-Barr virus rewires host epigenomes to drive stomach cancer
Researchers in Japan and Singapore have discovered a molecular mechanism that explains how Epstein-Barr virus (EBV) infection alters a host's epigenome to promote tumorigenesis (the transformation of normal cells into cancer cells) in certain types of stomach cancer.

MIPT bioinformaticians find way to personalize drug prescription against stomach cancer
Researchers from the Moscow Institute of Physics and Technology and their colleagues have developed the first technique for personalizing stomach cancer therapy based on RNA sequencing of tumor cells.

Scientists discover how a curvy, stomach cancer-causing bacterium maintains its shape
A new study published in eLife shows how a common stomach bacterium is able to keep its corkscrew-like shape as it grows.

A molecular switch for stomach disease
A research team from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) has revealed a new mechanism which controls the causes of infection with H. pylori, triggering the development of stomach diseases.

Many younger patients with stomach cancer have a distinct disease, Mayo research discovers
Many people under 60 who develop stomach cancer have a 'genetically and clinically distinct' disease, new Mayo Clinic research has discovered.

Common stomach bacteria is attracted to bleach
The widespread stomach pathogen Helicobacter pylori is attracted to bleach, according to new research by Arden Perkins of the University of Oregon in Eugene, Oregon, and colleagues.

Scientists discover origin of cell mask that hides stomach cancer
In a recent study, researchers from Hiroshima University have uncovered the origin of a layer of cells that look like normal stomach lining on top of sites of stomach cancer: it is produced by the cancer tissue itself.

Read More: Stomach Cancer News and Stomach Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to