Engineered anti-toxin antibodies improve efficacy

January 09, 2014

The effectiveness of toxin-neutralizing antibodies is considered to be mediated through the interaction of the variable region of the antibody and the toxin; however, recent studies suggest that the constant region (Fc) of antibodies also influence efficacy.

In this issue of the Journal of Clinical Investigation, Jeffrey Ravetch and colleagues at The Rockefeller University demonstrate that engineering the Fc domain of anti-toxin antibodies increases toxin neutralization activity through enhancing the interaction between toxin-targeting antibodies and the Fc receptor on immune cells. The authors found that mice expressing humanized FcR were better protected from anthrax toxin when given engineered anti-anthrax toxin antibodies.

This study suggests that engineering the Fc domains of antibodies can be used as a strategy to enhance antibody efficacy.
-end-
TITLE: Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity

AUTHOR CONTACT: Jeffrey V. Ravetch
The Rockefeller University, New York, NY, USA
Phone: 212-327-7323; Fax: ; E-mail: ravetch@rockefeller.edu

View this article at:http://www.jci.org/articles/view/72676?key=2cb7f03d851cec347394

JCI Journals

Related Immune Cells Articles from Brightsurf:

Gut immune cells may help send MS into remission
An international research team led by UCSF scientists has shown, for the first time, that gut immune cells travel to the brain during multiple sclerosis (MS) flare-ups in patients.

Immune cells sculpt circuits in the brain
Brain immune cells, called microglia, protect the brain from infection and inflammation.

How tumor cells evade the immune defense
Scientists are increasingly trying to use the body's own immune system to fight cancer.

Breast cancer cells can reprogram immune cells to assist in metastasis
Johns Hopkins Kimmel Cancer Center investigators report they have uncovered a new mechanism by which invasive breast cancer cells evade the immune system to metastasize, or spread, to other areas of the body.

Breast cancer cells turn killer immune cells into allies
Researchers at Johns Hopkins University School of Medicine have discovered that breast cancer cells can alter the function of immune cells known as Natural killer (NK) cells so that instead of killing the cancer cells, they facilitate their spread to other parts of the body.

Engineered immune cells recognize, attack human and mouse solid-tumor cancer cells
CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia.

Mapping immune cells in brain tumors
It is not always possible to completely remove malignant brain tumors by surgery so that further treatment is necessary.

Nutrient deficiency in tumor cells attracts cells that suppress the immune system
A study led by IDIBELL researchers and published this week in the American journal PNAS shows that, by depriving tumor cells of glucose, they release a large number of signaling molecules.

Experience matters for immune cells
The discovery that immune T cells have a spectrum of responsiveness could shed light on how our immune system responds to infections and cancer, and what goes wrong in immune diseases.

Immune cells against Alzheimer's?
German researchers have developed a novel, experimental approach against Alzheimer's.

Read More: Immune Cells News and Immune Cells Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.