Nav: Home

Study examines the effects of osteoporosis drugs in children with genetic bone disorders

January 09, 2017

Previous case reports in patients with osteogenesis imperfecta (OI) have suggested that treatment with bisphosphonates, which are commonly prescribed for osteoporosis, may be associated with atypical femur fractures. A new retrospective study of 119 children with OI indicates that such fractures are related to the severity of OI rather than to bisphosphonate use, however.

OI is a group of genetic disorders that affect the body's ability to make strong bones. People with the condition have bones that break easily, often from mild trauma or with no apparent cause.

"Children with severe OI break their bones less often when they receive intravenous bisphosphonate treatment, but unfortunately fractures still do occur. In this study, we found that bisphosphonate treatment did not change the radiological appearance of femur fractures," said Dr. Frank Rauch, senior author of the Journal of Bone and Mineral Research study.
-end-


Wiley

Related Osteoporosis Articles:

Mind the (osteoporosis treatment) gap!
A new review, referencing key clinical studies, guidelines and audits, outlines the main global challenges (and their solutions) facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health and fracture prevention.
Outwitting the 'silent thief' of osteoporosis
In a world first, new Australian research has revealed that genetic profiling can help predict whether an individual will break a bone through osteoporosis.
Osteoporosis: Antibody crystallized
Inhibiting a protein called Sclerostin could probably help treating the bone-loss disease osteoporosis.
JBMR perspective: A crisis in the treatment of osteoporosis
The remarkable progress made over the past 30 years to reduce fractures and dramatically improve the quality of life for millions of osteoporosis patients is rapidly being reversed, say two bone health experts in a Journal of Bone and Mineral Research article published online today.
The developmental origins of osteoporosis
Osteoporosis may have its origins in early life, but the consequences are not apparent until late adult life.
Task force provides guidance on use of osteoporosis drugs
A new report by a task force of the American Society for Bone and Mineral Research provides guidance on the use of bisphosphonates, which are the most commonly used medications for osteoporosis.
Whole genome-sequencing uncovers new genetic cause for osteoporosis
Using one of the world's most extensive genetics data sets, an international research team led by Dr.
Men far less likely to prevent, screen for osteoporosis
While the consequences of osteoporosis are worse in men than women -- including death -- older males are far less likely to take preventive measures against the potentially devastating bone-thinning disease or accept recommendations for screening, according to startling new research by North Shore-LIJ Health System geriatricians.
'Aquatic osteoporosis' jellifying lakes
North American lakes are suffering from declining calcium levels, says new research from Queen's University.
Osteoporosis, not just a woman's disease
While osteoporosis prevention and treatment efforts have historically been focused on post-menopausal women, a new study from Beth Israel Deaconess Medical Center suggests that critical opportunities are being lost by not focusing more attention on bone loss and fracture risk in older men.

Related Osteoporosis Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Bias And Perception
How does bias distort our thinking, our listening, our beliefs... and even our search results? How can we fight it? This hour, TED speakers explore ideas about the unconscious biases that shape us. Guests include writer and broadcaster Yassmin Abdel-Magied, climatologist J. Marshall Shepherd, journalist Andreas Ekström, and experimental psychologist Tony Salvador.
Now Playing: Science for the People

#513 Dinosaur Tails
This week: dinosaurs! We're discussing dinosaur tails, bipedalism, paleontology public outreach, dinosaur MOOCs, and other neat dinosaur related things with Dr. Scott Persons from the University of Alberta, who is also the author of the book "Dinosaurs of the Alberta Badlands".