Nav: Home

HRT tablets associated with increased risk of blood clots

January 09, 2019

Hormone replacement therapy (HRT) tablets are associated with a higher risk of rare but serious blood clots (known as venous thromboembolism or VTE), finds a large study in The BMJ today.

No increased risk was found for HRT skin patches, gels or creams, yet the vast majority of women choosing HRT continue to be prescribed oral preparations.

The researchers say these findings provide important information for women and their doctors to help them make the best treatment choices.

HRT is used to relieve menopausal symptoms such as hot flushes and night sweats. Different treatments are available depending on the symptoms. For example, tablets containing oestrogen only or a combination of oestrogen and progestogen, as well as 'transdermal' treatments, such as patches, gels and creams.

Previous trials have shown increased risks of blood clots in menopausal women using HRT, but there is a lack of information on risks associated with different types of HRT.

So Yana Vinogradova, a member of an epidemiological team at the University of Nottingham led by Julia Hippisley-Cox, set out to assess the association between VTE risk and all available types of HRT in the UK between 1998 and 2017.

Using two UK primary care databases (QResearch and CPRD), they compared HRT prescription records of over 80,000 women aged 40-79 years who developed blood clots (cases) with those of over 390,000 women who did not (controls).

Other relevant factors, such as lifestyle, family history of blood clots, and underlying conditions linked to blood clots were taken into account.

Most HRT tablets were found to be associated with increased VTE risk (9 extra cases per 10,000 women per year) compared with no HRT.

Tablets containing equine oestrogen, including single and combined preparations, were consistently associated with higher risks than tablets containing synthetic oestrogen.

Higher doses of oestrogen were also associated with higher VTE risk. However, no increased VTE risk was found for skin patches, gels and creams.

This is an observational study, and as such, can't establish cause, and the researchers point to some limitations that may have influenced the results. Nevertheless, they say this study "has provided a more detailed picture of the VTE risks for different HRT preparations and can help clinicians and women make treatment choices."

They suggest greater consideration should be given to transdermal HRT, particularly for women already at an increased VTE risk and in line with recent guidelines.
-end-


BMJ

Related Blood Clots Articles:

Hookah smoke may be associated with increased risk of blood clots
In a new study conducted in mice, researchers found that tobacco smoke from a hookah caused blood to function abnormally and be more likely to clot and quickly form blood clots.
Reducing the risk of blood clots in artificial heart valves
People with mechanical heart valves need blood thinners on a daily basis, because they have a higher risk of blood clots and stroke.
New study finds blood clots more likely in children who receive PICCs
A new study provides convincing evidence that the use of peripherally inserted central catheters (PICCs) to administer medicine and draw blood in children is associated with a significantly increased risk of blood clots (known as venous thromboembolism or VTE) compared with central venous catheters (CVCs) placed directly into the neck or chest.
New study provides insight into the mechanisms of blood clots in cancer patients
Researchers have identified a potential new signaling pathway that may help further the understanding of blood clot formation in cancer patients and ultimately help prevent this complication from occurring.
Cellular senescence is associated with age-related blood clots
Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time.
New guidance on potentially fatal blood clots published today
The European Society of Cardiology (ESC) Guidelines on acute pulmonary embolism are published online today in European Heart Journal, and on the ESC website.
One in five haematological cancer patients suffer blood clots or bleeding
In the years following haematological cancer, one in five survivors suffer a blood clot or bleeding which requires hospital treatment.
Targeting inflammation to better understand dangerous blood clots
Forty percent of people who develop venous thromboembolism don't know what caused it.
Impeding white blood cells in antiphospholipid syndrome reduced blood clots
A new study examined APS at the cellular level and found that two drugs reduced development of blood clots in mice affected with the condition.
Research unlocks biomechanical mystery behind deadly blood clots
Researchers at the University of Sydney have used biomechanical engineering techniques to unlock the mystery surrounding the mechanical forces that influence blood clotting.
More Blood Clots News and Blood Clots Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Climate Mindset
In the past few months, human beings have come together to fight a global threat. This hour, TED speakers explore how our response can be the catalyst to fight another global crisis: climate change. Guests include political strategist Tom Rivett-Carnac, diplomat Christiana Figueres, climate justice activist Xiye Bastida, and writer, illustrator, and artist Oliver Jeffers.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Speedy Beet
There are few musical moments more well-worn than the first four notes of Beethoven's Fifth Symphony. But in this short, we find out that Beethoven might have made a last-ditch effort to keep his music from ever feeling familiar, to keep pushing his listeners to a kind of psychological limit. Big thanks to our Brooklyn Philharmonic musicians: Deborah Buck and Suzy Perelman on violin, Arash Amini on cello, and Ah Ling Neu on viola. And check out The First Four Notes, Matthew Guerrieri's book on Beethoven's Fifth. Support Radiolab today at Radiolab.org/donate.