Nav: Home

A human model to test implants for cataract surgery

January 10, 2019

Researchers at the University of East Anglia in collaboration with Hoya Surgical Optics have improved a laboratory model that simulates cataract surgery on human donor eyes.

Their latest human model allows evaluation of artificial intraocular lens (IOL) implants under conditions that better reflect the post-surgical environment.

A cataract is a clouding of the eye's lens and affects millions worldwide. At present, the only way of treating cataract is with surgery and it is estimated that by 2020, more than 30 million such operations will be performed annually.

During cataract surgery, the eye's cloudy natural lens is removed and replaced with an IOL.

Initially, outcomes from cataract surgery are superb, but a haziness known as Posterior Capsule Opacification (PCO) can develop in a significant number of patients following surgery.

At the moment the only treatment for PCO is laser surgery - which is expensive and not without risks. There is therefore a need for better understanding the physiological events driving PCO and to better manage the condition.

The human capsular bag model was pioneered at UEA in the 1990s and has progressively evolved with time.

Lead researcher Prof Michael Wormstone, from UEA's School of Biological Sciences, said: "Our model now mimics the transient nature of inflammation that patients experience after cataract surgery. It is more reflective of clinical events and allows comparative evaluation of different types of IOLs.

"We believe this latest model will allow assessment of current commercial IOLs and will aid the development of next generation lenses."

The team used this clinically relevant model to assess the influence of two commercial market-leading IOLs (Alcon AcrysofTM and Hoya VivinexTM) on PCO management.

Their findings showed that cell growth on the posterior capsule was reduced, light-scatter in the central visual axis was found to be lower and growth on the IOL surface was significantly reduced with the Hoya VivinexTM IOL relative to the Alcon AcrysofTM.

The research team conclude that "our model system predicts that the Hoya VivinexTM is better able to manage events leading to PCO than the Alcon AcrysofTM IOL."
-end-
The research was funded by Hoya Surgical Optics and The Humane Research Trust.

'An in vitro human lens capsular bag model adopting a graded culture regime to assess putative impact of IOLs on PCO formation' is published in the journal Investigative Ophthalmology and Visual Science on January 10, 2019.

EDITOR'S NOTES

1/ For more information or to request an interview, please contact the UEA communications office on +44 (0)1603 593496 or email communications@uea.ac.uk.

2/ The paper is available via the following Dropbox link: https://www.dropbox.com/sh/k0jut48v2dayeyt/AADmPLvmD1WZxLCvDezSrl4Aa?dl=0

DOI: https://doi.org/10.1167/iovs.18-25930

3/ The University of East Anglia (UEA) is a UK Top 15 university. Known for its world-leading research and outstanding student experience, it was awarded Gold in the Teaching Excellence Framework. UEA is a leading member of Norwich Research Park, one of Europe's biggest concentrations of researchers in the fields of environment, health and plant science. http://www.uea.ac.uk

University of East Anglia

Related Cataract Surgery Articles:

UMass Amherst research may lead to non-surgical cataract treatment
Early phase discoveries by polymer physicist Murugappan Muthukumar at UMass Amherst regarding the fundamental science of proteins in the lens of the human eye could revolutionize treatment of cataract and presbyopia.
Innovative device simulates cataract replacement experience
A vision simulator developed by the Instituto de Optica, Consejo Superior de Investigaciones Científicas, Spain, works to help patients test artificial lens designs prior to implantation in the eye.
Major support for cataract study
Biologist wins NIH support for cataract study with focus on cellular processes that keep the eye lens transparent.
Refusing access to surgery recovery area at a UK hospital unless WHO Safe Surgery Checklist is fully complete
New research showing that refusal to allow surgery teams to take the patient to the recovery room after surgery unless the full WHO Safe Surgery Checklist has been complete is a highly effective way to improve use of the checklist.
UEA drug research could prevent secondary cataract
Scientists at the University of East Anglia may have found a way to prevent complications from surgery to treat cataract -- the world's leading cause of blindness.
Eating foods high in vitamin C cuts risk of cataract progression by a third
Women who ate more vitamin C-rich foods had a 33 percent risk reduction in cataract progression over 10 years, according to a study of UK twins published in Ophthalmology, journal of the American Academy of Ophthalmology.
Ultrasonic surgery reduces pain and swelling after chin surgery
For patients undergoing plastic surgery of the chin (genioplasty), the use of ultrasonic 'piezosurgery' equipment reduces trauma, pain, and swelling, compared to traditional surgical drills, reports a study in the The Journal of Craniofacial Surgery.
Stem cells regenerate human lens after cataract surgery, restoring vision
Researchers at University of California, San Diego School of Medicine and Shiley Eye Institute, with colleagues in China, have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses.
Cataract surgery lessens patients' dizziness
Older people with visual impairment can report feeling dizzy and falling.
Meniscus injury: Real surgery or sham surgery -- which is better for patients?
Should the non-surgical approach be preferred over surgical treatment or are there still advantages offered by surgery.

Related Cataract Surgery Reading:

Essentials of Cataract Surgery
by Bonnie An Henderson MD FACS (Author)

So You've Got A Cataract?: What You Need to Know About Cataract Surgery: A Patient's Guide to Modern Eye Surgery, Advanced Intraocular Lenses & Choosing Your Surgeon
by Dr David D Richardson M.D. (Author)

Cataract Surgery: Before, During & After: Preparing for surgery, enduring it gracefully and recovering in comfort
by Godfree Roberts

Cataract Surgery (Expert Consult)
by Roger F. Steinert MD (Author)

Cataract Surgery: A Guide to Treatment
by Bret L Fisher (Author), Paul E Garland (Author)

The Cataract Surgery Book: Options & Explanations for Patients

Cataract Surgery: Introduction and Preparation
by Lucio Buratto MD (Author), Stephen Brint MD (Author), Laura Sacchi MD (Author)

Cataracts: A Patient’s Guide to Treatment
by David F. Chang MD (Author), Bryan Lee MD (Author)

Phacoemulsification Cataract Surgery
by Rajen Gupta (Author)

Cataract Surgery: A Patient's Guide to Cataract Treatment
by Addicus Books

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Approaching With Kindness
We often forget to say the words "thank you." But can those two words change how you — and those around you — look at the world? This hour, TED speakers on the power of gratitude and appreciation. Guests include author AJ Jacobs, author and former baseball player Mike Robbins, Dr. Laura Trice, Professor of Management Christine Porath, and former Danish politician Özlem Cekic.
Now Playing: Science for the People

#509 Anisogamy: The Beginning of Male and Female
This week we discuss how the sperm and egg came to be, and how a difference of reproductive interest has led to sexual conflict in bed bugs. We'll be speaking with Dr. Geoff Parker, an evolutionary biologist credited with developing a theory to explain the evolution of two sexes, about anisogamy, sexual reproduction through the fusion of two different gametes: the egg and the sperm. Then we'll speak with Dr. Roberto Pereira, research scientist in urban entomology at the University of Florida, about traumatic insemination in bed bugs.