Nav: Home

Role of protein engineering techniques in synthetic biology

January 11, 2017

Proteins are the major biochemical workhorses that carry out multitude of physiological functions in an organism. The astonishing feature of the proteins is their ability to accomplish their specific functionalities under in-vitro conditions. Protein engineering has been a powerful tool in synthetic biology for last couple of decades. Protein engineering has been employed to generate vast numbers of enzymes/proteins possessing immense therapeutic and industrial potential. The field is expanding for the last two decades in both industrial and health care sectors. As per the 2014 research report released by Markets & Markets, the protein engineering market was $610 million and is expected to grow to $1,460 million by 2020. Numerous experimental and computational approaches have been developed to generate synthetic protein universe with desired specificity and enhanced performance in comparison to their natural counterparts. However, no updated review is available covering different categories of protein engineering techniques and their patent applications till date. In this context, the article,An Overview of Computational and Experimental Methods for Designing Novel Proteins, published in Recent Patents in Biotechnology (Vol10(3), 235-63, 2016) provides a comprehensive context on several of the novel engineering approaches that are being widely used under the categories of rational design, de novo design, directed evolution and combinatorial approach.This article sheds light on the technicalities, advantages and pitfalls of the existing methodologies along with their applications, recent patents obtained using the engineered proteins in the biomedical/biotechnological sectors, and the current and future perspectives of protein engineering techniques.
For more information about the article, please visit

Reference: Gulati, K.; (2016). An Overview of Computational and Experimental Methods for Designing Novel Proteins. Recent Patents on Biotechnology, DOI: 10.2174/1872208310666161013152249

Bentham Science Publishers

Related Synthetic Biology Articles:

Tennessee researchers join call for responsible development of synthetic biology
Engineering biology is transforming technology and science. Researchers in the international Genome Project-write, including two authors from the UTIA Center for Agricultural Synthetic Biology, outline the technological advances needed to secure a safe, responsible future in the Oct.
Scientists chart course toward a new world of synthetic biology
A UC Berkeley team with NSF funding has compiled a roadmap for the future of synthetic or engineering biology, based on the input of 80 leaders in the field from more than 30 institutions.
DFG presents position paper on synthetic biology
Clear distinction between synthetic biology and underlying methods required / No new potential risks associated with current research work
Commandeering microbes pave way for synthetic biology in military environments
A team of scientists from the US Army Research Laboratory and the Massachusetts Institute of Technology have developed and demonstrated a pioneering synthetic biology tool to deliver DNA programming into a broad range of bacteria.
BioBits: Teaching synthetic biology to K-12 students
As biologists have probed deeper into the genetic underpinnings of life, K-12 schools have struggled to provide a curriculum that reflects those advances.
Sensor strategy a boon for synthetic biology
Rice University synthetic biologists have invented a technology to dial up or down the sensitivity of bacterial biosensors.
Drug-producing bacteria possible with synthetic biology breakthrough
Bacteria could be programmed to efficiently produce drugs, thanks to breakthrough research into synthetic biology using engineering principles, from the University of Warwick and the University of Surrey.
Report highlights opportunities and risks associated with synthetic biology and bioengineering
Human genome editing, 3-D-printed replacement organs and artificial photosynthesis - the field of bioengineering offers great promise for tackling the major challenges that face our society.
Illinois researchers develop gene circuit design strategy to advance synthetic biology
Scientists and engineers have developed synthetic gene circuits that program the functionality, performance, and behavior of living cells.
New report proposes framework to identify vulnerabilities posed by synthetic biology
Given the possible security vulnerabilities related to developments in synthetic biology -- a field that uses technologies to modify or create organisms or biological components -- a new report by the National Academies of Sciences, Engineering, and Medicine proposes a framework to identify and prioritize potential areas of concern associated with the field.
More Synthetic Biology News and Synthetic Biology Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#538 Nobels and Astrophysics
This week we start with this year's physics Nobel Prize awarded to Jim Peebles, Michel Mayor, and Didier Queloz and finish with a discussion of the Nobel Prizes as a way to award and highlight important science. Are they still relevant? When science breakthroughs are built on the backs of hundreds -- and sometimes thousands -- of people's hard work, how do you pick just three to highlight? Join host Rachelle Saunders and astrophysicist, author, and science communicator Ethan Siegel for their chat about astrophysics and Nobel Prizes.