Nav: Home

Role of protein engineering techniques in synthetic biology

January 11, 2017

Proteins are the major biochemical workhorses that carry out multitude of physiological functions in an organism. The astonishing feature of the proteins is their ability to accomplish their specific functionalities under in-vitro conditions. Protein engineering has been a powerful tool in synthetic biology for last couple of decades. Protein engineering has been employed to generate vast numbers of enzymes/proteins possessing immense therapeutic and industrial potential. The field is expanding for the last two decades in both industrial and health care sectors. As per the 2014 research report released by Markets & Markets, the protein engineering market was $610 million and is expected to grow to $1,460 million by 2020. Numerous experimental and computational approaches have been developed to generate synthetic protein universe with desired specificity and enhanced performance in comparison to their natural counterparts. However, no updated review is available covering different categories of protein engineering techniques and their patent applications till date. In this context, the article,An Overview of Computational and Experimental Methods for Designing Novel Proteins, published in Recent Patents in Biotechnology (Vol10(3), 235-63, 2016) provides a comprehensive context on several of the novel engineering approaches that are being widely used under the categories of rational design, de novo design, directed evolution and combinatorial approach.This article sheds light on the technicalities, advantages and pitfalls of the existing methodologies along with their applications, recent patents obtained using the engineered proteins in the biomedical/biotechnological sectors, and the current and future perspectives of protein engineering techniques.
-end-
For more information about the article, please visit https://benthamscience.com/journals/recent-patents-on-biotechnology/volume/10/issue/3/page/235/

Reference: Gulati, K.; (2016). An Overview of Computational and Experimental Methods for Designing Novel Proteins. Recent Patents on Biotechnology, DOI: 10.2174/1872208310666161013152249

Bentham Science Publishers

Related Synthetic Biology Articles:

Cell-free synthetic biology comes of age
In a review paper published in Nature Reviews Genetics, Professor Michael Jewett explores how cell-free gene expression stands to help the field of synthetic biology dramatically impact society, from the environment to medicine to education.
Scientists develop electrochemical platform for cell-free synthetic biology
Scientists at the University of Toronto (U of T) and Arizona State University (ASU) have developed the first direct gene circuit to electrode interface by combining cell-free synthetic biology with state-of-the-art nanostructured electrodes.
Gene-OFF switches tool up synthetic biology
Wyss researchers and their colloaborators have developed two types of programmable repressor elements that can switch off the production of an output protein in synthetic biology circuits by up to 300-fold in response to almost any triggering nucleotide sequence.
Tennessee researchers join call for responsible development of synthetic biology
Engineering biology is transforming technology and science. Researchers in the international Genome Project-write, including two authors from the UTIA Center for Agricultural Synthetic Biology, outline the technological advances needed to secure a safe, responsible future in the Oct.
Scientists chart course toward a new world of synthetic biology
A UC Berkeley team with NSF funding has compiled a roadmap for the future of synthetic or engineering biology, based on the input of 80 leaders in the field from more than 30 institutions.
DFG presents position paper on synthetic biology
Clear distinction between synthetic biology and underlying methods required / No new potential risks associated with current research work
Commandeering microbes pave way for synthetic biology in military environments
A team of scientists from the US Army Research Laboratory and the Massachusetts Institute of Technology have developed and demonstrated a pioneering synthetic biology tool to deliver DNA programming into a broad range of bacteria.
BioBits: Teaching synthetic biology to K-12 students
As biologists have probed deeper into the genetic underpinnings of life, K-12 schools have struggled to provide a curriculum that reflects those advances.
Sensor strategy a boon for synthetic biology
Rice University synthetic biologists have invented a technology to dial up or down the sensitivity of bacterial biosensors.
Drug-producing bacteria possible with synthetic biology breakthrough
Bacteria could be programmed to efficiently produce drugs, thanks to breakthrough research into synthetic biology using engineering principles, from the University of Warwick and the University of Surrey.
More Synthetic Biology News and Synthetic Biology Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Meditations on Loneliness
Original broadcast date: April 24, 2020. We're a social species now living in isolation. But loneliness was a problem well before this era of social distancing. This hour, TED speakers explore how we can live and make peace with loneliness. Guests on the show include author and illustrator Jonny Sun, psychologist Susan Pinker, architect Grace Kim, and writer Suleika Jaouad.
Now Playing: Science for the People

#565 The Great Wide Indoors
We're all spending a bit more time indoors this summer than we probably figured. But did you ever stop to think about why the places we live and work as designed the way they are? And how they could be designed better? We're talking with Emily Anthes about her new book "The Great Indoors: The Surprising Science of how Buildings Shape our Behavior, Health and Happiness".
Now Playing: Radiolab

The Third. A TED Talk.
Jad gives a TED talk about his life as a journalist and how Radiolab has evolved over the years. Here's how TED described it:How do you end a story? Host of Radiolab Jad Abumrad tells how his search for an answer led him home to the mountains of Tennessee, where he met an unexpected teacher: Dolly Parton.Jad Nicholas Abumrad is a Lebanese-American radio host, composer and producer. He is the founder of the syndicated public radio program Radiolab, which is broadcast on over 600 radio stations nationwide and is downloaded more than 120 million times a year as a podcast. He also created More Perfect, a podcast that tells the stories behind the Supreme Court's most famous decisions. And most recently, Dolly Parton's America, a nine-episode podcast exploring the life and times of the iconic country music star. Abumrad has received three Peabody Awards and was named a MacArthur Fellow in 2011.