Nav: Home

Variation between strains may account for differences in vulnerability to infection

January 11, 2018

Scientists have long sought to explain why people respond differently to bacterial infections. In the case of TB, for example, less than 10 percent of those infected with Mycobacterium tuberculosis develop severe lung disease, while others remain symptom-free.

In some cases, genetic defects have been shown to make the human immune system susceptible to infection. Yet human genetics may not be the whole story, according to research published today in PLOS Pathogens. It suggests that variations among strains within a single bacterial species may also provoke varied immune responsiveness in their human hosts. This variability is mainly contributed by viruses that infect bacteria.

Uri Sela, a clinical fellow in the laboratory of Vincent A. Fischetti, obtained these findings by analyzing blood samples from healthy volunteers whose immune cells had been challenged with different strains of Staphylococcus aureus. In many other studies, however, scientists have drawn conclusions about the immune system's interactions with a bacterium based on experiments with a single strain, which may not be representative of the species as a whole, Sela says.

"Our findings are novel and unexpected," he notes, "and may set the stage for better ways to predict a patient's disease outcome and tailor treatment accordingly."
-end-


Rockefeller University

Related Immune Cells Articles:

Identification of new populations of immune cells in the lungs
In an article published in Nature Communications, the Immunophysiology Laboratory of the GIGA Institute, headed by Prof.
A genomic barcode tracker for immune cells
A new research method to pinpoint the immune cells that recognise cancer could significantly change how we treat the disease.
Scientists reminded immune cells on what side they should be
International group of scientists in the joint study of the laboratory of the Wistar Institute, University of Pittsburgh and I.M.
Dead cells disrupt how immune cells respond to wounds and patrol for infection
Immune cells prioritise the clearance of dead cells overriding their normal migration to sites of injury.
Study gives new perspective on production of blood cells and immune cells
A new study provides a thorough accounting of blood cell production from hematopoietic stem cells.
More Immune Cells News and Immune Cells Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...