Early child deprivation and neglect impair memory and executive functioning at age 16

January 14, 2019

Young children experiencing deprivation and neglect in institutional settings have impaired memory and executive functioning at ages 8 and 16 compared with peers placed early in quality foster homes, report investigators at Boston Children's Hospital. The study, interpreting the latest findings from the randomized controlled trial, the Bucharest Early Intervention Project (BEIP), was published today in the Proceedings of the National Academy of Sciences.

"This study shows us that the effects of deprivation and neglect in early childhood continue well into the second decade of life, providing strong evidence that early experience has a long-term impact on cognitive functioning in adolescence -- a very important period of social and biological development," says Mark Wade, PhD, of the Division of Developmental Medicine at Boston Children's Hospital and the paper's first author.

An estimated 8 million children worldwide live in institutions. The long-running BEIP study compares psychosocial, cognitive and brain outcomes in children raised in Romanian orphanages, versus those adopted early in life by carefully vetted foster families and children who were never in institutions.

An analysis last fall reported high levels of mental health problems when institutionally-reared children reached adolescence, in particular difficult behaviors such as rule-breaking, excessive arguing with authority figures, stealing or assaulting peers. But these problems were reduced among children placed early with foster families.

The new analysis focused on cognitive functioning, in particular memory and executive functioning. "Executive functioning includes several cognitive processes that help individuals be more goal-oriented and solve problems," explains Wade. "It is important in academic achievement and social functioning in childhood, and is also related to long-term occupational attainment, income and other aspects psychosocial well-being."

The findings:"Institutionally-reared children start out with more difficulties, but when they are assigned early to positive caregiving environments, they may demonstrate some catch-up on certain aspects of executive functioning," says Wade. "A safe, nurturing, and cognitively stimulating environment in a family-based setting is critical to children's long-term success, and may help some who struggle early get back on track during adolescence."

EEG predictor?

The study also found that an EEG measure of brain activity at age 8, namely higher resting EEG alpha power, predicted better executive functioning at ages 8, 12, and 16.

"This may point to a neural mechanism that supports children's cognitive development," says Charles A. Nelson, PhD, director of the Laboratories of Cognitive Neuroscience at Boston Children's Hospital and senior author on the paper.
Nathan A. Fox of the University of Maryland and Charles H. Zeanah of Tulane University School of Medicine were coauthors on the paper. The study was funded by the John D. and Catherine T. MacArthur Foundation, the Binder Family Foundation, the National Institute of Mental Health of the NIH (R01MH091363), and a Banting postdoctoral fellowship.

About Boston Children's Hospital

Boston Children's Hospital, the primary pediatric teaching affiliate of Harvard Medical School, is home to the world's largest research enterprise based at a pediatric medical center. Its discoveries have benefited both children and adults since 1869. Today, more than 3,000 scientists, including 8 members of the National Academy of Sciences, 18 members of the National Academy of Medicine and 12 Howard Hughes Medical Investigators comprise Boston Children's research community. Founded as a 20-bed hospital for children, Boston Children's is now a 415-bed comprehensive center for pediatric and adolescent health care. For more, visit our Vector and Thriving blogs and follow us on social media @BostonChildrens, @BCH_Innovation, Facebook and YouTube.

Boston Children's Hospital

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