Early life family structure and microbially induced cancer risk and more

January 15, 2007

In a 28 year study of 261 Japanese-American men who carried Helicobacter pylori belonging to a large family or being born later in the family was associated with a significantly increased risk of developing gastric adenocarcinoma late in life. These results suggest that early-life social environment plays a significant role in risk of microbially induced malignancies expressing five to eight decades later.

Citation: Blaser MJ, Nomura A, Lee J, Stemmerman GN, Perez-Perez GI (2007) Early-life family structure and microbially induced cancer risk. PLoS Med 4(1): e7.

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040007
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-04-01-blaser.pdf

CONTACT:

Martin Blaser
New York University
School of Medicine
550 First Avenue
New York, NY 10016 United States of America
+1 212-263-6394
martin.blaser@nyumc.org

Related PLoS Medicine Perspective article:

Citation: Lagiou P, Trichopoulos D (2007) Parental family structure, Helicobacter pylori, and gastric adenocarcinoma. PLoS Med 4(1): e25.

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040025
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-04-01-lagiou.pdf

CONTACT:

Pagona Lagiou
University of Athens Medical School
Department of Hygiene and Epidemiology
75 M. Asias Street
Goudi
Athens, GR-115 27 Greece
plagiou@hsph.harvard.edu


A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism

Changes in the cleavage site of the Gag substrate for the HIV protease can convey resistance to protease inhibitors and might contribute to virologic failure during therapy that includes these drugs.

Citation: Nijhuis M, van Maarseveen NM, Lastere S, Schipper P, Coakley E, et al. (2007) A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism. PLoS Med 4(1): e36.

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040036
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-04-01-boucher.pdf
Related image for press use: http://www.plos.org/press/plme-04-01-boucher.jpg
Caption: Schematic Representation of the Distribution of all Amino Acid Changes Appearing during in vitro Selection Experiments Using RO033-4649

CONTACT:

Charles Boucher
University Medical Centre Utrecht
Eijkman Winkler Centre, Department of Virology
Heidelberglaan 100
Utrecht, Utrecht 3584CX Netherlands
+31 302506526
+31 302505426 (fax)
c.boucher@umcutrecht.nl
-end-
About PLoS Medicine

PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org

All works published in PLoS Medicine are open access. Everything is immediately available without cost to anyone, anywhere--to read, download, redistribute, include in databases, and otherwise use--subject only to the condition that the original authorship is properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.

About the Public Library of Science

The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org

PLOS

Related Helicobacter Pylori Articles from Brightsurf:

Small RNA as a central player in infections
The most important pathogenicity factors of the gastric pathogen Helicobacter pylori are centrally regulated by a small RNA molecule, NikS.

Research finds daily cranberry intake associated with reduced with reduced H. pylori infection rates
A new clinical trial found consuming cranberry juice containing 44 mg of proanthocyanidins (or ''PACs'') per 240-mL serving twice daily for eight weeks resulted in a 20% reduction in the H. pylori infection rate in Chinese adult participants, when compared to those consuming lower amounts of juice and a placebo.

Oncotarget: MicroRNA (miR) dysregulation during Helicobacter pylori-induced gastric
Oncotarget Volume 11, Issue 10 reported that dysregulation of noncoding micro RNA molecules has been associated with immune cell activation in the context of Helicobacter pylori-induced gastric inflammation as well as carcinogenesis, but also with downregulation of mismatch repair genes, and may interfere with immune checkpoint proteins that lead to the overexpression of antigens on gastric tumor cells.

Common stomach bacteria is attracted to bleach
The widespread stomach pathogen Helicobacter pylori is attracted to bleach, according to new research by Arden Perkins of the University of Oregon in Eugene, Oregon, and colleagues.

How gastric stem cells fight bacteria
Stem cells are not only key players in tissue regeneration, they are also capable of taking direct action against bacteria.

Cancer prevention drug also disables H. pylori bacterium
A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.

Infection biology: What makes Helicobacter so adaptable?
The bacterial pathogen Helicobacter pylori owes its worldwide distribution to its genetic adaptability.

Eradicating Helicobacter pylori infections may be a key treatment for Parkinson's disease
While human genetic mutations are involved in a small number of Parkinson's disease (PD) cases, the vast majority of cases are of unknown environmental causes, prompting enormous interest in identifying environmental risk factors involved.

Gastric cancer: A new strategy used by Helicobacter pylori to target mitochondria
Scientists from the Institut Pasteur and CNRS have recently identified new strategies used by Helicobacter pylori bacteria to infect cells.

How Helicobacter pylori causes gastric cancer
Gastric cancer is one of the five most fatal types of cancer.

Read More: Helicobacter Pylori News and Helicobacter Pylori Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.