Outcomes after deep brain stimulation for uncontrolled tourette syndrome

January 16, 2018

BottomLine: Deep brain stimulation was associated with some symptom improvement in a small group of patients with uncontrolled Tourette syndrome but also some adverse events.

Why The Research Is Interesting: Deep brain stimulation is a surgical treatment where a device is implanted to deliver electrical stimulation to targeted parts of the brain. The procedure is not approved by the U.S. Food and Drug Administration for Tourette syndrome but some reports of its use suggest it may be potentially valuable. An international database and registry was launched in 2012 because only a small number of deep brain stimulation procedures are performed for Tourette syndrome around the world and there was a need to organize all information about outcomes from the procedure in one place.

Who: 171 of 185 patients with uncontrolled Tourette syndrome who underwent deep brain stimulation in 2012-2016 at 31 institutions in 10 countries

What (Study Measures): Deep brain stimulation (exposure); scores on a scale of tic severity and adverse events (outcomes)

How (Study Design): Describes one-year outcome data from patients in the International Deep Brain Stimulation Database and Registry. This is a cohort/observational study. People were followed over time but because researchers are not intervening for purposes of the study they cannot control natural differences that could explain study findings.

Authors: Michael S. Okun M.D., of the University of Florida, Gainesville, and coauthors

Results: Average tic severity improved 45 percent one year after the deep brain stimulation device was implanted; 56 of 158 patients (35.4 percent) reported adverse events, the most common were dysarthria (weakness or difficulty in controlling speech muscles) and paresthesias (pins-and-needles), while a few patients had bleeding in the skull and infection.

Study Limitations: Data come from an observational study and were drawn from multiple sites with a lack of standard inclusion criteria for the registry; different surgical techniques or treatment approaches at the multiple sites also could have affected the results.

Study Conclusions: The first-year results of this multinational electronic collaboration strengthen the notion that DBS could be a potential surgical treatment for select patients with Tourette syndrome. Practitioners should be aware of the high number of stimulation-related adverse events and that these are likely reversible.
To read the full study, please visit the For The Media website.


Editor's Note:  The article contains conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

To place an electronic embedded link in your story: Links will be live at the embargo time: http://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2017.4317

JAMA Neurology

Related Brain Articles from Brightsurf:

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows.

Children with asymptomatic brain bleeds as newborns show normal brain development at age 2
A study by UNC researchers finds that neurodevelopmental scores and gray matter volumes at age two years did not differ between children who had MRI-confirmed asymptomatic subdural hemorrhages when they were neonates, compared to children with no history of subdural hemorrhage.

New model of human brain 'conversations' could inform research on brain disease, cognition
A team of Indiana University neuroscientists has built a new model of human brain networks that sheds light on how the brain functions.

Human brain size gene triggers bigger brain in monkeys
Dresden and Japanese researchers show that a human-specific gene causes a larger neocortex in the common marmoset, a non-human primate.

Unique insight into development of the human brain: Model of the early embryonic brain
Stem cell researchers from the University of Copenhagen have designed a model of an early embryonic brain.

An optical brain-to-brain interface supports information exchange for locomotion control
Chinese researchers established an optical BtBI that supports rapid information transmission for precise locomotion control, thus providing a proof-of-principle demonstration of fast BtBI for real-time behavioral control.

Transplanting human nerve cells into a mouse brain reveals how they wire into brain circuits
A team of researchers led by Pierre Vanderhaeghen and Vincent Bonin (VIB-KU Leuven, Université libre de Bruxelles and NERF) showed how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells.

Brain scans reveal how the human brain compensates when one hemisphere is removed
Researchers studying six adults who had one of their brain hemispheres removed during childhood to reduce epileptic seizures found that the remaining half of the brain formed unusually strong connections between different functional brain networks, which potentially help the body to function as if the brain were intact.

Alcohol byproduct contributes to brain chemistry changes in specific brain regions
Study of mouse models provides clear implications for new targets to treat alcohol use disorder and fetal alcohol syndrome.

Scientists predict the areas of the brain to stimulate transitions between different brain states
Using a computer model of the brain, Gustavo Deco, director of the Center for Brain and Cognition, and Josephine Cruzat, a member of his team, together with a group of international collaborators, have developed an innovative method published in Proceedings of the National Academy of Sciences on Sept.

Read More: Brain News and Brain Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.