Nav: Home

Study gauges efficacy of drugs against pork tapeworm

January 16, 2020

Taenia solium--also called pork tapeworm--is a parasite which causes disease around the world, particularly in very poor communities with deficient santiation and where pigs roam free. Researchers have now analyzed the efficacy and adverse effects of three chemotherapeutics against T. solium and report their results in a review published in PLOS Neglected Tropical Diseases.

In its adult form, T. solium causes an intestinal infection known as taeniasis. Humans can become infected with taeniasis when they eat raw or undercooked, infected pork that contains T. solium larvae. A cysticerci form of disease can also develop when humans or pigs ingest the tapeworm eggs; this form can lead to muscle and central nervous system symptoms including seizures (epilepsy if they are recurrent). In endemic countries, T. solium can be responsible for approximately 30% of epilepsy cases. However, in specific communities this can be up to 70%.

In the new work, Michelle Haby of the University of Sonora, Mexico, and colleagues reviewed existing literature on three existing deworming drugs which have shown some efficacy in treating taeniasis. The drugs are albendazole (ALB), praziquantel (PZQ) and niclosamide (NICL). 20 studies met the inclusion criteria for the review; 11 used a before-after study design while 9 were controlled trials. The drug tested was ALB in 7 studies, NICL in 4 studies, PZQ in 7 studies, and a combination of PZQ and NICL in two studies.

Meta-analysis showed that a single dose of PZQ 10 mg/kg cured 99.5% of T. solium taeniasis; ALB 400 mg per day for three consecutive days led to a 96.4% cure rate; and NICL 2g led to a 84.3% cure rate. Less effective were PZQ 5mg/kg, with a 89.0% cure rate, and a single dose of ALB 400 mg, with a 52.0% cure rate. Most studies reported no or only mild and transient side effects following administration of the drugs.

The drugs "were effective as taenicides and could be considered for use in mass drug administration programs for the control of T. solium taeniasis," the researchers say. "Future efficacy research should focus on the conduct of high quality randomized controlled trials of the three different drugs and varying doses, both in comparison to placebo and in head-to-head trials."
Peer-reviewed Systematic review People

In your coverage please use this URL to provide access to the freely available paper: 0007873

Citation: Haby MM, Sosa Leon LA, Luciañez A, Nicholls RS, Reveiz L, et al. (2020) Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis. PLOS Neglected Tropical Diseases 14(1): e0007873.

Image Credit: Pan American Health Organization/ World Health Organization official photo (CC BY 4.0)

Image Caption: Preventative chemotherapy for the control of soil-transmitted helminthiasis in the Americas region.

Funding: This review was funded by PAHO/WHO. The funders had no role in the study design, data collection or analysis, decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests exist.


Related Drugs Articles:

Wallflowers could lead to new drugs
Plant-derived chemicals called cardenolides - like digitoxin - have long been used to treat heart disease, and have shown potential as cancer therapies.
Bristol pioneers use of VR for designing new drugs
Researchers at the University of Bristol are pioneering the use of virtual reality (VR) as a tool to design the next generation of drug treatments.
Towards better anti-cancer drugs
The Bayreuth biochemist Dr. Claus-D. Kuhn and his research team have deciphered how the important human oncogene CDK8 is activated in cells of healthy individuals.
Separating drugs with MagLev
The composition of suspicious powders that may contain illicit drugs can be analyzed using a quick and simple method called magneto-Archimedes levitation (MagLev), according to a new study published in the journal Angewandte Chemie.
People are more likely to try drugs for the first time during the summer
American teenagers and adults are more likely to try illegal or recreational drugs for the first time in the summer, a new study shows.
Drugs used to enhance sexual experiences, especially in UK
Combining drugs with sex is common regardless of gender or sexual orientation, reveals new research by UCL and the Global Drug Survey into global trends of substance-linked sex.
Promising new drugs for old pathogen Mtb
UConn researchers are targeting a metabolic pathway, the dihydrofolate reductase pathway, crucial for amino acid synthesis to treat TB infections.
Can psychedelic drugs heal?
Many people think of psychedelics as relics from the hippie generation or something taken by ravers and music festival-goers, but they may one day be used to treat disorders ranging from social anxiety to depression, according to research presented at the annual convention of the American Psychological Association.
New uses for existing antiviral drugs
Broad-spectrum antiviral drugs work against a range of viral diseases, but developing them can be costly and time consuming.
New TB drugs possible with understanding of old antibiotic
Tuberculosis, and other life-threatening microbial diseases, could be more effectively tackled with future drugs, thanks to new research into an old antibiotic by the University of Warwick and the Francis Crick Institute.
More Drugs News and Drugs Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at