Nav: Home

Rapamycin tones down the toxicity of HIV-1 reactivation strategies

January 17, 2017

Although patients infected with HIV-1 can successfully manage the disease by taking antiretroviral therapies, these therapies cannot completely eradicate the virus because HIV-1 can persist in a latent reservoir of T cells without replicating. More complete eradication of HIV-1 infection could be achieved using therapies that reactivate the virus in the latent reservoir, but the existing strategies are considered too toxic to use as treatments in HIV-1 patients. This week in the JCI, work performed in Robert Siliciano's lab at Johns Hopkins University School of Medicine evaluated whether a strategy combining T cell activation with the immunosuppressive drug rapamycin could reactivate latent HIV-1 reservoirs without causing toxic side effects. Rapamycin treatment reduced proinflammatory cytokine release and other signs of toxicity without decreasing HIV-1 reactivation in T cells from HIV-1-infected individuals. Importantly, the rapamycin treatment did not impair the ability of the immune system to recognize infected T cells. These findings indicate that rapamycin could be used to reduce the toxicity of strategies targeting the HIV-1 latent reservoir.
-end-
TITLE: Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity

AUTHOR CONTACT:

Robert F. Siliciano
Johns Hopkins University School Of Medicine
rsiliciano@jhmi.edu

View this article at:http://www.jci.org/articles/view/89552?key=5d32d232ee55831ed7e7

JCI Journals

Related Virus Articles:

Tracking the HI virus
A European research team led by Prof. Christian Eggeling from the Friedrich Schiller University Jena, the Leibniz Institute of Photonic Technology (Leibniz IPHT), and the University of Oxford has now succeeded in using high-resolution imaging to make visible to the millisecond how the HI virus spreads between living cells and which molecules it requires for this purpose.
Prior Zika virus or dengue virus infection does not affect secondary infections in monkeys
Previous infection with either Zika virus or dengue virus has no apparent effect on the clinical course of subsequent infection with the other virus, according to a study published August 1 in the open-access journal PLOS Pathogens by David O'Connor of the University of Wisconsin-Madison, and colleagues.
Smartphone virus scanner is not what you think
The current leading method to assess the presence of viruses and other biological markers of disease is effective but large and expensive.
Early dengue virus infection could "defuse" zika virus
The Zika virus outbreak in Latin America has affected over 60 million people up to now.
Catch a virus by its tail
At a glance: Research uncovers key mechanism that allows some of the deadliest human RNA viruses to orchestrate the precise copying of the individual pieces of their viral genome and replicate.
More Virus News and Virus Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...