Nav: Home

Not just small adults: Pediatric liver transplant recipients need special care

January 17, 2017

A new review discusses important consideration when caring for children who have received liver transplants.

Young patients process immunosuppressive agents differently than older patients, which can have effects on drug absorption, distribution, metabolism, and excretion. Children will also be exposed to immunosuppressive drugs longer than adults, which can impact their growth and their long-term risk of infection and cancer.

"Caring for children after liver transplantation is extremely rewarding thanks to their excellent outcomes," said Dr. Tamir Miloh, lead author of the Liver Transplantation review. "Tailoring the immunosuppressant regimen in pediatrics is complex, however, due to physiologic differences in pharmacokinetics, impact on growth and development, infection risk, carcinogenesis, and likelihood of non-adherence on one hand and tolerance on the other. Pre-transplant and continuous post-transplant caregiver and patient education is crucial for optimal outcomes."
-end-


Wiley

Related Infection Articles:

Male infertility: Urogenital infection as a possible cause
In couples who have not been able to have children, male infertility is the cause in at least half of cases.
A novel approach to seeing dengue infection in the body
Positron emission tomography (PET) paired with the glucose metabolism probe, fluorodeoxyglucose (FDG), is considered 'old' technology in the field of cancer.
Smelling the risk of infection
Humans and monkeys are social beings and benefit from a community.
Tuberculosis and HIV co-infection
The HIV virus increases the potency of the tuberculosis bacterium (Mtb) by affecting a central function of the immune system.
New insight into course and transmission of Zika infection
In one of the first and largest studies of its kind, a research team lead by virologists at Beth Israel Deaconess Medical Center has characterized the progression of two strains of the viral infection.
UTMB researchers protect against lethal Ebola Sudan infection four days after infection
Researchers at The University of Texas Medical Branch at Galveston, in collaboration with Arbutus Biopharma Corporation, have protected nonhuman primates against Ebola Sudan four days following exposure to the virus.
How tumor necrosis factor protects against infection
Tumor necrosis factor (TNF), a messenger substance in the immune system, plays an important role in triggering chronic inflammatory diseases.
Gene amplification -- the fast track to infection
Researchers at UmeƄ University in Sweden are first to discover that bacteria can multiply disease-inducing genes which are needed to rapidly cause infection.
New test allows for one-step diagnosis of HCV infection
The current standard in diagnosing Hepatitis C virus (HCV) infection requires two sequential steps that make it suboptimal, costly, inconvenient, time consuming, and globally not widely available or affordable.
Do dressings prevent infection?
There is insufficient evidence to know whether dressings reduce the risk of wound infection after surgery and, in some cases, leaving a wound exposed may be better, say researchers in The BMJ today.

Related Infection Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Climate Crisis
There's no greater threat to humanity than climate change. What can we do to stop the worst consequences? This hour, TED speakers explore how we can save our planet and whether we can do it in time. Guests include climate activist Greta Thunberg, chemical engineer Jennifer Wilcox, research scientist Sean Davis, food innovator Bruce Friedrich, and psychologist Per Espen Stoknes.
Now Playing: Science for the People

#527 Honey I CRISPR'd the Kids
This week we're coming to you from Awesome Con in Washington, D.C. There, host Bethany Brookshire led a panel of three amazing guests to talk about the promise and perils of CRISPR, and what happens now that CRISPR babies have (maybe?) been born. Featuring science writer Tina Saey, molecular biologist Anne Simon, and bioethicist Alan Regenberg. A Nobel Prize winner argues banning CRISPR babies won’t work Geneticists push for a 5-year global ban on gene-edited babies A CRISPR spin-off causes unintended typos in DNA News of the first gene-edited babies ignited a firestorm The researcher who created CRISPR twins defends...