Nav: Home

Addressing expected challenges after resumption of HPV vaccination

January 17, 2019

In Japan, HPV vaccination program started in 2010 and the HPV vaccine became a nationally recommended routine immunization for girls aged 12-16 years in April 2013. However, because cases of young girls with widespread pain and movement disorders after vaccination were reported in the media, in June 2013, Japan's Ministry of Health, Labour and Welfare (MHLW) announced the suspension of its recommendation for routine HPV immunization.

Previous research at Osaka University showed that the HPV vaccination hiatus would increase the risk of HPV infection and future cervical cancer for girls who did not get vaccinated.

HPV vaccination is vital to reduce the risk of HPV infection and cervical cancer; however, no reports on countermeasures against expected challenges after resumption of HPV vaccination have been published.

Researchers at Osaka University compiled countermeasures against predictable challenges after resumption of HPV vaccination, publishing in the Lancet Oncology.

Every year, about 9,000 women are diagnosed with cervical cancer and 2,000 - 3,000 women die of the cancer. A major factor for the development of cervical cancer is infection with HPV, which is mainly transmitted through sexual contact.

This research group demonstrated two possible challenges after resumption of the MHLW's recommendation for HPV vaccination:

1. Reducing the risk of cervical cancer that will increase by the suspension of the recommendation
2. Promoting HPV vaccination

The group discussed countermeasures against these challenges, making the following proposals for providing information and fostering public acceptance of the vaccine.

A. Easy access to immunization for women who are older than the normally targeted ages of 12-16 years and who were not vaccinated during the suspension of recommendation for HPV vaccination
B. Introduction of the nine-valent vaccine, which can prevent 80-90 percent of cervical cancer
C. Immunization for boys of the same ages as the targeted girls
D. Reducing health damage due to the suspension of recommendation for HPV vaccination by encouraging medical check-ups and cervical cancer screening
E. Promoting HPV vaccination again by using a behavioral economics approach
F. Providing media with correct information about the HPV vaccine

Dr. Yutaka Ueda says, "Resumption of the government recommendation for HPV vaccination will be insufficient to deal with the expected challenges. It's necessary to reduce negative effects of the suspension of recommendation for HPV vaccination. We hope our proposals will reduce the development of cervical cancer in Japanese women, and, moreover, protect women's health."
The comment, "Beyond resumption of the Japanese Government's recommendation of the HPV vaccine" was published in the Lancet Oncology at DOI:

About Osaka University Osaka University was founded in 1931 as one of the seven imperial universities of Japan and now has expanded to one of Japan's leading comprehensive universities. The University has now embarked on open research revolution from a position as Japan's most innovative university and among the most innovative institutions in the world according to Reuters 2015 Top 100 Innovative Universities and the Nature Index Innovation 2017. The university's ability to innovate from the stage of fundamental research through the creation of useful technology with economic impact stems from its broad disciplinary spectrum. Website:

Osaka University

Related Cancer Articles:

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.
Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.
Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.
Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.
More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.
New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.
American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.
Oncotarget: Cancer pioneer employs physics to approach cancer in last research article
In the cover article of Tuesday's issue of Oncotarget, James Frost, MD, PhD, Kenneth Pienta, MD, and the late Donald Coffey, Ph.D., use a theory of physical and biophysical symmetry to derive a new conceptualization of cancer.
Health indicators for newborns of breast cancer survivors may vary by cancer type
In a study published in the International Journal of Cancer, researchers from the UNC Lineberger Comprehensive Cancer Center analyzed health indicators for children born to young breast cancer survivors in North Carolina.
Few women with history of breast cancer and ovarian cancer take a recommended genetic test
More than 80 percent of women living with a history of breast or ovarian cancer at high-risk of having a gene mutation have never taken the test that can detect it.
More Cancer News and Cancer Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Our Relationship With Water
We need water to live. But with rising seas and so many lacking clean water – water is in crisis and so are we. This hour, TED speakers explore ideas around restoring our relationship with water. Guests on the show include legal scholar Kelsey Leonard, artist LaToya Ruby Frazier, and community organizer Colette Pichon Battle.
Now Playing: Science for the People

#568 Poker Face Psychology
Anyone who's seen pop culture depictions of poker might think statistics and math is the only way to get ahead. But no, there's psychology too. Author Maria Konnikova took her Ph.D. in psychology to the poker table, and turned out to be good. So good, she went pro in poker, and learned all about her own biases on the way. We're talking about her new book "The Biggest Bluff: How I Learned to Pay Attention, Master Myself, and Win".
Now Playing: Radiolab

First things first: our very own Latif Nasser has an exciting new show on Netflix. He talks to Jad about the hidden forces of the world that connect us all. Then, with an eye on the upcoming election, we take a look back: at two pieces from More Perfect Season 3 about Constitutional amendments that determine who gets to vote. Former Radiolab producer Julia Longoria takes us to Washington, D.C. The capital is at the heart of our democracy, but it's not a state, and it wasn't until the 23rd Amendment that its people got the right to vote for president. But that still left DC without full representation in Congress; D.C. sends a "non-voting delegate" to the House. Julia profiles that delegate, Congresswoman Eleanor Holmes Norton, and her unique approach to fighting for power in a virtually powerless role. Second, Radiolab producer Sarah Qari looks at a current fight to lower the US voting age to 16 that harkens back to the fight for the 26th Amendment in the 1960s. Eighteen-year-olds at the time argued that if they were old enough to be drafted to fight in the War, they were old enough to have a voice in our democracy. But what about today, when even younger Americans are finding themselves at the center of national political debates? Does it mean we should lower the voting age even further? This episode was reported and produced by Julia Longoria and Sarah Qari. Check out Latif Nasser's new Netflix show Connected here. Support Radiolab today at