Nav: Home

Study identifies brain's connections which keep related memories distinct from each other

January 20, 2017

The team studied the hippocampus and prefrontal cortex -- two regions of the brain critical to memory function -- as damage in these areas can induce severe memory loss.

However, both areas are connected by a complex network of direct and indirect pathways, and the challenge has been until now, how to identify the precise routes through which these brain regions interact in memory formation.

Researchers from Bristol's Schools of Physiology, Pharmacology and Neuroscience and Clinical Sciences used a new novel pharmacogenetic technique to deactivate specific neural pathways from the hippocampus to the prefrontal cortex in rats. They then tested the rats' memory for objects presented at specific points in time, and in specific locations, to model episodic memory function' in humans.

The team found that one pathway from the hippocampus controlled the 'temporal' aspects of the memory such as those which enable a subject to remember when they had encountered an object, while a separate pathway enabled subjects to remember an object's location.

They found that by deactivating specific neural pathways and preventing the hippocampus from talking to the prefrontal cortex, episodic memory function was significantly disrupted.

Professor Clea Warburton, said: "Episodic memory stores an individual's unique recollection of a specific event and is important for remembering significant events in our lives. This type of integrated memory is important in helping us to remember significant events in our lives, and works by linking different types of information.

"For example, even remembering routine things such as where we parked the car requires our brain to store and link different types of information. We must remember what kind of car we have, when, and where we parked it. Linking these different components of memory depends on clear communication between different brain regions which work together forming complex memory networks.

"These findings, reveal for the first time, an important aspect of memory function critical to episodic memory and could help with developing new therapeutics to aid memory loss."
-end-
The work was funded by the Biotechnology and Biological Sciences Research Council (BBSRC).

University of Bristol

Related Memory Articles:

Taking photos of experiences boosts visual memory, impairs auditory memory
A quick glance at any social media platform will tell you that people love taking photos of their experiences -- whether they're lying on the beach, touring a museum, or just waiting in line at the grocery store.
Think you know how to improve your memory? Think again
Research from Katherine Duncan at the University of Toronto suggests we may have to rethink how we improve memory.
Improving memory with magnets
The ability to remember sounds, and manipulate them in our minds, is incredibly important to our daily lives -- without it we would not be able to understand a sentence, or do simple arithmetic.
Who has the better memory -- men or women?
In the battle of the sexes, women have long claimed that they can remember things better and longer than men can.
New study of the memory through optogenetics
A collaboration between Universitat Autònoma de Barcelona and Harvard University pioneers the increase of memory using optogenetics in mice in Spain.
Peppermint tea can help improve your memory
Peppermint tea can improve long-term and working memory and in healthy adults.
A new glimpse into working memory
MIT study finds bursts of neural activity as the brain holds information in mind, overturns a long-held model.
Memory ensembles
For over forty years, neuro-scientists have been interested in the biological mechanisms underlying the storage of the information that our brain records every day.
What is your memory style?
Why is it that some people have richly detailed recollection of past experiences (episodic memory), while others tend to remember just the facts without details (semantic memory)?
Watching a memory form
Neuroscientists at Rosalind Franklin University of Medicine and Science have discovered a novel mechanism for memory formation.

Related Memory Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#SB2 2019 Science Birthday Minisode: Mary Golda Ross
Our second annual Science Birthday is here, and this year we celebrate the wonderful Mary Golda Ross, born 9 August 1908. She died in 2008 at age 99, but left a lasting mark on the science of rocketry and space exploration as an early woman in engineering, and one of the first Native Americans in engineering. Join Rachelle and Bethany for this very special birthday minisode celebrating Mary and her achievements. Thanks to our Patreons who make this show possible! Read more about Mary G. Ross: Interview with Mary Ross on Lash Publications International, by Laurel Sheppard Meet Mary Golda...