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A predictive risk map for the nematode parasite Mansonella perstans in Uganda

January 21, 2016

Infection with the nematode parasite Mansonella perstans is one of the most neglected of the neglected tropical diseases. Although symptoms are usually mild, the infection can cause swelling, fever, headaches and abdominal pain and an optimal treatment has not yet been determined. The parasite is transmitted by biting midges found in many areas of sub-Saharan Africa however the exact species of the vector is unknown. A team of researchers from the University of Copenhagen, the Swiss Tropical and Public Health Institute and Uganda Ministry of Health, used data from a survey of 76 schools across Uganda to model areas of high risk of M. perstans infection and examine its overlap with other common parasitic infections. This study will be published in PLOS Neglected Tropical Diseases.

Between 2000 and 2003 a national survey gathered blood-samples from 12,207 pupils aged 5-19 years old across 76 schools in Uganda. The survey tested for the presence of three common parasitic infections: M. perstans, Wuchereria bancrofti (the causative agent of lymphatic filariasis) and Plasmodium (the parasite responsible for Malaria). M. perstans infections were observed in 62% of the schools, with prevalence ranging from 0.4% to 73%. Co-infection with W. bancrofti was found in 0.3% of pupils and co-infection with Plasmodium in 3%. Only 9 pupils were recorded as infected with all three species.

The researchers examined a range of bioclimatic factors to see which were associated with increased levels of M. perstans infection. Of the different types of vegetation (forest cover, open vegetation and cropland) only forest had a significant positive association with infection. A significant positive association was also found with a high density of cattle, although not with other livestock such as sheep, goat, pig or chicken. A significant negative association was found with land surface temperature. These results suggest that infection is associated with cooler or forested areas with reduced temperature variation, and areas with high densities of farmed cattle. Older students were found to be at a significantly higher risk of infection and positive associations were found with W. bancrofti infection in areas where the parasites overlapped.

Bayesian multivariate regression analysis was used to build up predictive risk map for M. perstans across Uganda. High risk of infection was predicted for the central area, with pockets of increased risk in the north-west and south-east. Low risk was predicted in the north-eastern and central south regions. "Although this predictive risk map is a model, and the data is based on schoolchildren only, it does provide a deeper understanding of the zoogeographical patterns of this highly neglected disease and may be useful for targeting areas for surveillance and measuring elimination progress", says lead author and assistant professor Anna-Sofie Stensgaard, from the Center for Macroecology, Evolution and Climate, University of Copenhagen. "It amazes me how little we know about this relatively widespread parasite, but this study has provided some valuable clues as to the ecology of both the parasite and the as yet unidentified species of insect vector in Uganda", concludes Anna-Sofie Stensgaard.
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All works published in PLOS Neglected Tropical Diseases are open access, which means that everything is immediately and freely available. Use this URL in your coverage to provide readers access to the paper upon publication:

http://dx.plos.org/10.1371/journal.pntd.0004319 (Link goes live upon article publication)

Related Image for Press Use: Image Credit: Paul Erik Simonsen

Caption: Mansonella perstans microfilariae in a blood smear.

Contact:

Anna-Sofie Stensgaard
45-35321318
asstensgaard@snm.ku.dk

Funding: The field surveys received financial support from the DBL-Centre for Health Research and Development, Denmark. ASS is thankful to the Danish National Research Foundation for its support of the Center for Macroecology, Evolution and Climate. PV is grateful to the Swiss National Science Foundation for financial support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

About PLOS Neglected Tropical Diseases

PLOS Neglected Tropical Diseases is a peer-reviewed, open-access journal devoted to the pathology, epidemiology, prevention, treatment, and control of the neglected tropical diseases, as well as public policy relevant to this group of diseases. All works published in PLOS Neglected Tropical Diseases are open access, which means that everything is immediately and freely available subject only to the condition that the original authorship and source are properly attributed. The Public Library of Science uses the Creative Commons Attribution License, and copyright is retained by the authors.

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