Drug can reduce pain for stroke patients

January 22, 2001

The drug lamotrigine can reduce the pain that affects some stroke patients, according to a study in the January 23 issue of Neurology, the scientific journal of the American Academy of Neurology. Central post-stroke pain occurs in eight percent of stroke patients and is difficult to treat. The only current treatment, amitriptyline, doesn't work for many patients, and has many side effects.

The pain is felt in areas of the body that have sensory loss from the stroke. Researchers think the pain occurs when the stroke damages the fibers in the brain or in the spinal cord that lead to the thalamus area of the brain. The loss of sensory information to the brain creates a hyperexcitability, or excessive response to stimuli, in that area of the brain.

"Lamotrigine, which has mainly been used for epilepsy patients, reduces hyperexcitability in brain cells, so we wanted to see if it would help people with central post-stroke pain," said study author and neurologist Troels Staehelin Jensen, MD, PhD, of Aarhus University Hospital in Aarhus, Denmark.

For the study, 30 people with central post-stroke pain were given lamotrigine in a randomized, double-blind study. The participants took lamotrigine for eight weeks, waited two weeks with no medication and then took a placebo for eight weeks, or vice versa.

Taking lamotrigine reduced the pain patients felt by an average of 30 percent. Twelve patients' responses were considered clinically significant improvements, with those patients reporting reductions of two or more points on a scale of 0-10 while taking the drug.

While taking lamotrigine, patients had few side effects, including mild rashes and headaches.

"The current treatment for this type of pain -- the antidepressant amitriptyline -- can cause side effects including sedation, low blood pressure and cardiac arrhythmia, so this new treatment is a good option for people who cannot tolerate amitriptyline or don't respond to it," Jensen said.
The study was supported by grants from the Danish Medical Research Council and the Danish Pain Research Center. Glaxo Wellcome, which manufactures lamotrigine, provided the drugs, technical support and covered patients' transportation expenses. A neurologist is a medical doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system.

The American Academy of Neurology, an association of more than 17,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research.

For more information about the American Academy of Neurology, visit its Web site at www.aan.com. For online neurological health and wellness information, visit NeuroVista at www.aan.com/neurovista

For more information contact:
Kathy Stone 651-695-2763 or kstone@aan.com

American Academy of Neurology

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