Nav: Home

FRAX intervention and assessment thresholds for seven Latin American countries

January 22, 2018

Latin America's population is ageing and as a result the region is facing a rapid increase in the prevalence of osteoporosis and fragility fractures.

The newly published Fracture Risk Assessment Tool (FRAX) -based intervention thresholds for seven Latin American countries represent a substantial advance in the detection of both men and women at high risk of fracture, particularly in the elderly.1

FRAX is used to calculate the ten-year probability of fragility fracture in both men and women, with or without the inclusion of bone mineral density (BMD).2

The new study has used country-specific epidemiological data to compute FRAX-based intervention and BMD assessment thresholds for men and women aged over 40 years, for the following seven countries: Argentina, Brazil, Colombia, Chile, Ecuador, Mexico and Venezuela.

The age-specific intervention thresholds for the seven countries varied considerably, ranging from 1.5 to 27.5% in Argentina, 3.8 to 25.2% in Brazil, 1.6 up to 20.0% in Chile, 0.6 to 10.2% in Colombia, 0.9 up to 13.6% in Ecuador, 2.6 to 20.0% in Mexico, and 0.7 up to 22.0% in Venezuela at the age of 40 and 90 years, respectively.

Professor Patricia Clark, Head of the Clinical Epidemiology Unit, Hospital Infantil de Mexico, stated:

"Due to the ageing of the population, Latin America is seeing steep increases in the number of individuals suffering fragility fractures. For example, in Mexico, we project a 531% increase in the number of hip fractures between 2005 and 2050, with similar estimates for Brazil. It is therefore of great importance that we are able to accurately estimate patients' risk of fracture in order to take preventive action before potentially devastating fragility fractures occur."

Fractures of the spine and hip have a serious impact on quality of life, with hip fractures in particular resulting in long-term disability and early death for approximately 20-24% of patients within a year of the fracture. For this reason, identifying individuals who are at high risk of suffering future fractures is a first critical step - followed by providing lifestyle and pharmacological therapy to those who benefit most.

Professor John Kanis, Emeritus Professor in Human Metabolism, Director of the Centre for Metabolic Bone Diseases, University of Sheffield, UK, and Professorial Fellow at the Catholic University of Australia (Melbourne), stated:

"The newly established intervention thresholds enhance the utility of the FRAX tool for these seven countries, offering clinicians important information to guide treatment decisions, and providing public health agencies with a framework to develop appropriate prevention programs."

Significantly, the study has revealed great heterogeneity in fracture probabilities and thresholds between the seven countries. The highest probabilities in individuals with prior fracture were seen in Argentina, and the lowest in Ecuador. This confirms that country-specific FRAX models are required, rather than a global regional model.
-end-
1. Clark, P., Denova-Gutiérrez, E., Zerbini, C. et al. FRAX-based intervention and assessment thresholds in seven Latin American countries. Osteoporos Int (2017). https://doi.org/10.1007/s00198-017-4341-4https://link.springer.com/article/10.1007/s00198-017-4341-4

2. FRAX® - Fracture Risk Assessment Tool https://www.sheffield.ac.uk/FRAX/

About FRAX

FRAX® is a simple calculation tool that integrates clinical information in a quantitative manner to predict a 10-year probability of major osteoporotic fracture for both women and men in different countries. The tool was developed at the Centre for Metabolic Bone Diseases, University of Sheffield, UK in collaboration with international researchers. It assists primary health-care providers to better target people in need of interventions to reduce fracture risk, thus improving the allocation of health-care resources towards patients most likely to benefit from treatment. The FRAX calculator is now freely available for 63 countries and in 34 languages. https://www.sheffield.ac.uk/FRAX/

About IOF

The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers as well as 240 patient, medical and research societies in 99 locations, work together to make fracture prevention and healthy mobility a worldwide heath care priority. http://www.iofbonehealth.org / http://www.facebook.com/iofbonehealth @iofbonehealth

International Osteoporosis Foundation

Related Hip Fractures Articles:

Proof that magnesium could prevent fractures
Magnesium could hold the key to preventing one of the most preventable causes of disability in middle-aged to elderly people, according to new research led by academics at the universities of Bristol and Eastern Finland.
Osteoporosis screening and treatment fall short for women with hip fractures
It's important to identify and treat osteoporosis following hip fracture, but a large study found low rates of assessment and treatment in postmenopausal women who had suffered a hip fracture.
Hip fractures may have both short and long-term effects on survival in elderly individuals
A new analysis of numerous studies indicates that men and women aged 60 years and older who have experienced a hip fracture are at increased risk of dying not only in the short term after the fracture, but also a number of years later.
Benzodiazepine and related drug use increases hip fractures in persons with Alzheimer's disease
The use of benzodiazepines and related drugs increases the risk of hip fracture by 43 percent in persons with Alzheimer's disease, according to a new study from the University of Eastern Finland.
Towards better hip replacements
Some potentially good news for aging Baby Boomers: researchers believe that they have developed a hip replacement that will last longer and create fewer problems for the people who receive them than those currently in use.
Understanding the epidemiology of fractures in diabetes
The paper reports on the complexity of fracture epidemiology in diabetes, and makes recommendations for the clinician and for future research.
Hip fractures: Most elderly unlikely to fully recover
One in every two older persons who have suffered a hip fracture will never be as physically active and independent as they were before.
Surgery associated with reduced fractures in patients with hyperparathyroidism
Surgery to remove the parathyroid was associated with reduced fracture risk in patients with primary hyperparathyroidism, whereas bisphosphonate treatment was associated with increased bone mineral density but not fewer fractures.
AAOS recommends specific treatment, rehabilitation for elderly patients with hip fractures
The American Academy of Orthopaedic Surgeons Board of Directors recently approved Appropriate Use Criteria for treatment and rehabilitation of elderly patients with hip fractures, in addition to postoperative direction to help prevent fractures from recurring.
Hip osteoarthritis may not appear on x-ray
In the majority of cases, hip x-rays are not reliable for diagnosing hip osteoarthritis (OA), and can delay the treatment of this debilitating disease.

Related Hip Fractures Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Don't Fear Math
Why do many of us hate, even fear math? Why are we convinced we're bad at it? This hour, TED speakers explore the myths we tell ourselves and how changing our approach can unlock the beauty of math. Guests include budgeting specialist Phylecia Jones, mathematician and educator Dan Finkel, math teacher Eddie Woo, educator Masha Gershman, and radio personality and eternal math nerd Adam Spencer.
Now Playing: Science for the People

#518 With Genetic Knowledge Comes the Need for Counselling
This week we delve into genetic testing - for yourself and your future children. We speak with Jane Tiller, lawyer and genetic counsellor, about genetic tests that are available to the public, and what to do with the results of these tests. And we talk with Noam Shomron, associate professor at the Sackler School of Medicine at Tel Aviv University, about technological advancements his lab has made in the genetic testing of fetuses.