Nav: Home

Analyzing aspirin use in patients without cardiovascular disease

January 22, 2019

Bottom Line: This study analyzed combined results from 13 randomized clinical trials with more than 164,000 participants to assess aspirin use with the prevention of cardiovascular events and bleeding in people without cardiovascular disease. Results suggest aspirin use was associated with lower risk (absolute risk reduction of 0.38 percent) for cardiovascular events (a composite of cardiovascular death, nonfatal heart attack and nonfatal stroke) and increased risk of major bleeding (absolute risk increase of 0.47 percent). The role of aspirin for the primary prevention of cardiovascular events has remained controversial because of an increased risk for bleeding. This study (a meta-analysis that combines the results of multiple studies identified in a systematic review) is limited by the availability and quality of reported data.
-end-
Authors: Sean L. Zheng, B.M., B.Ch., M.A., M.R.C.P., Imperial College London, and Alistair J. Roddick, B.Sc., King's College London, United Kingdom

(doi:10.1001/jama.2018.20578)

Editor's Note:  Please see the article for additional information, including author contributions and affiliations, financial disclosures, funding and support, etc.

Want to embed a link to this study in your story? This full-text link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/2721178?guestAccessKey=b6c6e6e2-80a8-449e-9278-a863ceaa9c67

JAMA

Related Cardiovascular Disease Articles:

Premature death from cardiovascular disease
National data were used to examine changes from 2000 to 2015 in premature death (ages 25 to 64) from cardiovascular disease in the United States.
Ultrasound: The potential power for cardiovascular disease therapy
In the current issue of Cardiovascular Innovations and Applications volume 4, issue 2, pp.
Despite the ACA, millions of Americans with cardiovascular disease still can't get care
Cardiovascular disease (CVD) is the leading cause of death for Americans, yet millions with CVD or cardiovascular risk factors (CVRF) still can't access the care they need, even years after the implementation of the Affordable Care Act (ACA).
Excess weight and body fat cause cardiovascular disease
In the first Mendelian randomization study to look at this, researchers have found evidence that excess weight and body fat cause a range of heart and blood vessel diseases (rather than just being associated with it).
Disease remission associated with 80% reduction in risk of cardiovascular outcomes
The results of a study presented today at the Annual European Congress of Rheumatology (EULAR 2019) demonstrate that remission in patients with rheumatoid arthritis is associated with an 80% reduction in risk of cardiovascular outcomes.
Enzyme may indicate predisposition to cardiovascular disease
Study suggests that people with low levels of PDIA1 in blood plasma may be at high risk of thrombosis; this group also investigated PDIA1's specific interactions in cancer.
Cardiovascular disease in China
This study analyzed data from the Global Burden of Disease Study to look at the rate of cardiovascular disease (CVD) in China along with death and disability from CVD from 1990 to 2016.
Obstructive sleep apnea and cardiovascular disease in women
Obstructive Sleep Apnea and Cardiovascular Disease in Women In the current issue of Cardiovascular Innovations and Applications (Special Issue on Women's Cardiovascular Health, Volume 3, Number 4, 2019, Guest Editor Gladys P.
Nearly half of all adult Americans have cardiovascular disease
At least 48 percent of all adults in the United States have some form of cardiovascular disease, according to the latest statistics provided by the American Heart Association.
Analyzing aspirin use in patients without cardiovascular disease
This study analyzed combined results from 13 randomized clinical trials with more than 164,000 participants to assess aspirin use with the prevention of cardiovascular events and bleeding in people without cardiovascular disease.
More Cardiovascular Disease News and Cardiovascular Disease Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

Risk
Why do we revere risk-takers, even when their actions terrify us? Why are some better at taking risks than others? This hour, TED speakers explore the alluring, dangerous, and calculated sides of risk. Guests include professional rock climber Alex Honnold, economist Mariana Mazzucato, psychology researcher Kashfia Rahman, structural engineer and bridge designer Ian Firth, and risk intelligence expert Dylan Evans.
Now Playing: Science for the People

#541 Wayfinding
These days when we want to know where we are or how to get where we want to go, most of us will pull out a smart phone with a built-in GPS and map app. Some of us old timers might still use an old school paper map from time to time. But we didn't always used to lean so heavily on maps and technology, and in some remote places of the world some people still navigate and wayfind their way without the aid of these tools... and in some cases do better without them. This week, host Rachelle Saunders...
Now Playing: Radiolab

Dolly Parton's America: Neon Moss
Today on Radiolab, we're bringing you the fourth episode of Jad's special series, Dolly Parton's America. In this episode, Jad goes back up the mountain to visit Dolly's actual Tennessee mountain home, where she tells stories about her first trips out of the holler. Back on the mountaintop, standing under the rain by the Little Pigeon River, the trip triggers memories of Jad's first visit to his father's childhood home, and opens the gateway to dizzying stories of music and migration. Support Radiolab today at Radiolab.org/donate.