Plasminogen-related Growth Factors

January 22, 1998

P>Editors: Gregory R. Bock (Organizer) and Jamie A. Goode

This symposium is based on a proposal made by Ermanno Gherardi


E. Gherardi Chairman's introduction


R. F. Doolittle, G. Spraggon and S. J. Everse
Evolution of vertebrate fibrin formation and the process of its dissolution
Discussion


E. Gherardi, R. Gonzalez Manzano, A. Cottage, K. Hawker and S. Aparicio
Evolution of plasminogen-related growth factors (HGF/SF and HGFl/MSP)
Discussion


General discussion I
Evolution of plasminogen and plasminogen-related growth factors


F. J. Castellino and S. G. McCance
The kringle domains of human plasminogen
Discussion


T. de los Santos, J. Wang and E. Reich
Structure and function of microplasminogen: reconstitution of microplasminogen and microplasmin from isolated fragments
Discussion


E. Gherardi, G. Hartmann, J. Hepple, D. Chirgadze, N. Srinivasan and T. Blundell
Domain structure of hepatocyte growth factor/scatter factor (HGF/SF)
Discussion


General discussion II
HGF/SF activation
Cleavage of pro-MSP to active MSP


D. B. Rifkin, P.E. Gleizes, J. Harpel, I. Nunes, J. Munger, R. Mazzieri and I. Noguera
Plasminogen/plasminogen activator and growth factor activation
Discussion


G. F. Vande Woude, M. Jeffers, J. Cortner, G. Alvord, I. Tsarfaty and J. Resau
Met-HGF/SF: tumorigenesis, invasion and metastasis
Discussion


A. Bardelli and P. M. Comoglio
Scatter factor receptors are key players in a unique multistep program leading to invasive growth
Discussion


General discussion III
Heparan sulfate as a co-receptor in the HGF/SF-Met system


A. C. E. Streit and C. D. Stern
Competence for neural induction: HGF/SF, HGFl/MSP and the c-Met receptor
Discussion


C. Birchmeier, F. Bladt and T. Yamaai
The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian development
Discussion


E. J. Leonard
Biological aspects of macrophage-stimulating protein (MSP) and its receptor
Discussion


K. Matsumoto and T. Nakamura
HGF: its organotrophic role and therapeutic potential
Discussion


E. M. Rosen, K. Lamszus, J. Laterra, P. J. Polverini, J. S. Rubin and I. D. Goldberg
HGF/SF in angiogenesis
Discussion


W. Birchmeier, V. Brinkmann, C. Niemann, S. Meiners, S. DiCesare, H. Naundorf and M. Sachs
Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells
Discussion


General discussion IV
Angiostatin: a plasminogen-related growth inhibitor


E. Gherardi
Chairman's summing-up


Index of contributors
Subject index
-end-


Novartis Foundation

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