Plasminogen-related Growth Factors

January 22, 1998

P>Editors: Gregory R. Bock (Organizer) and Jamie A. Goode

This symposium is based on a proposal made by Ermanno Gherardi

E. Gherardi Chairman's introduction

R. F. Doolittle, G. Spraggon and S. J. Everse
Evolution of vertebrate fibrin formation and the process of its dissolution

E. Gherardi, R. Gonzalez Manzano, A. Cottage, K. Hawker and S. Aparicio
Evolution of plasminogen-related growth factors (HGF/SF and HGFl/MSP)

General discussion I
Evolution of plasminogen and plasminogen-related growth factors

F. J. Castellino and S. G. McCance
The kringle domains of human plasminogen

T. de los Santos, J. Wang and E. Reich
Structure and function of microplasminogen: reconstitution of microplasminogen and microplasmin from isolated fragments

E. Gherardi, G. Hartmann, J. Hepple, D. Chirgadze, N. Srinivasan and T. Blundell
Domain structure of hepatocyte growth factor/scatter factor (HGF/SF)

General discussion II
HGF/SF activation
Cleavage of pro-MSP to active MSP

D. B. Rifkin, P.E. Gleizes, J. Harpel, I. Nunes, J. Munger, R. Mazzieri and I. Noguera
Plasminogen/plasminogen activator and growth factor activation

G. F. Vande Woude, M. Jeffers, J. Cortner, G. Alvord, I. Tsarfaty and J. Resau
Met-HGF/SF: tumorigenesis, invasion and metastasis

A. Bardelli and P. M. Comoglio
Scatter factor receptors are key players in a unique multistep program leading to invasive growth

General discussion III
Heparan sulfate as a co-receptor in the HGF/SF-Met system

A. C. E. Streit and C. D. Stern
Competence for neural induction: HGF/SF, HGFl/MSP and the c-Met receptor

C. Birchmeier, F. Bladt and T. Yamaai
The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian development

E. J. Leonard
Biological aspects of macrophage-stimulating protein (MSP) and its receptor

K. Matsumoto and T. Nakamura
HGF: its organotrophic role and therapeutic potential

E. M. Rosen, K. Lamszus, J. Laterra, P. J. Polverini, J. S. Rubin and I. D. Goldberg
HGF/SF in angiogenesis

W. Birchmeier, V. Brinkmann, C. Niemann, S. Meiners, S. DiCesare, H. Naundorf and M. Sachs
Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells

General discussion IV
Angiostatin: a plasminogen-related growth inhibitor

E. Gherardi
Chairman's summing-up

Index of contributors
Subject index

Novartis Foundation

Related Evolution Articles from Brightsurf:

Seeing evolution happening before your eyes
Researchers from the European Molecular Biology Laboratory in Heidelberg established an automated pipeline to create mutations in genomic enhancers that let them watch evolution unfold before their eyes.

A timeline on the evolution of reptiles
A statistical analysis of that vast database is helping scientists better understand the evolution of these cold-blooded vertebrates by contradicting a widely held theory that major transitions in evolution always happened in big, quick (geologically speaking) bursts, triggered by major environmental shifts.

Looking at evolution's genealogy from home
Evolution leaves its traces in particular in genomes. A team headed by Dr.

How boundaries become bridges in evolution
The mechanisms that make organisms locally fit and those responsible for change are distinct and occur sequentially in evolution.

Genome evolution goes digital
Dr. Alan Herbert from InsideOutBio describes ground-breaking research in a paper published online by Royal Society Open Science.

Paleontology: Experiments in evolution
A new find from Patagonia sheds light on the evolution of large predatory dinosaurs.

A window into evolution
The C4 cycle supercharges photosynthesis and evolved independently more than 62 times.

Is evolution predictable?
An international team of scientists working with Heliconius butterflies at the Smithsonian Tropical Research Institute (STRI) in Panama was faced with a mystery: how do pairs of unrelated butterflies from Peru to Costa Rica evolve nearly the same wing-color patterns over and over again?

Predicting evolution
A new method of 're-barcoding' DNA allows scientists to track rapid evolution in yeast.

Insect evolution: Insect evolution
Scientists at Ludwig-Maximilians-Universitaet (LMU) in Munich have shown that the incidence of midge and fly larvae in amber is far higher than previously thought.

Read More: Evolution News and Evolution Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to