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Advances in 3D and organoid cell culture

January 23, 2019

A new collection of reviews and original research articles in SLAS Technology illustrate how new technologies and advanced cell culture are accelerating basic research, drug discovery and drug development.

When cultured under 3D conditions, human induced pluripotent stem cells (iPSCs) provide optimized systems that more accurately reflect disease-related target mutations, compound pharmacology and toxicology.

The review articles in this collection feature a comprehensive, two-part, overview of the use of 3D culture, including spheroids and organoids, when growing human iPSCs for use in disease modeling, compound screening and lead optimization. The research articles address the high-throughput screening of glioblastoma oncospheres in drug, a microfluidic approach to optimization of culture conditions for human iPSCs differentiation, and novel hydrogels for use in microlayered tissue constructs.

Collectively, this special collection, published in the February 2019 issue of SLAS Technology, illustrates how the human iPS cells and 3D cell culture technology provide powerful approaches to the development of novel and more effective therapies.
  • Editorial Introduction: Convergence of Three-Dimensional Cell Culture and Human iPS Cells: Improving Clinical Relevance in Drug Discovery by Guest Editor Richard M. Eglen, Ph.D., Corning Life Sciences (Tewksbury, MA, USA)

  • Review Article: Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 1: Target Identification and Lead Optimization

  • Review Article: Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 2: Spheroids, Organoids and Disease Modeling

  • Original Research: Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy

  • Original Research: Full Factorial Microfluidic Designs and Devices for Parallelizing Human Pluripotent Stem Cell Differentiation

  • Original Research: A Single-Step Self-Assembly Approach for the Fabrication of Aligned and Multilayered Three-Dimensional Tissue Constructs Using Multidomain Peptide Hydrogel
-end-
Free access to the SLAS Technology special collection on Advances in 3D and Organoid Cell Culture at http://journals.sagepub.com/toc/jlad/24/1 is sponsored by Corning Life Sciences. For more information about SLAS and its journals, visit http://www.slas.org/journals. For more information about Corning Life Sciences, visit http://www.corning.com/lifesciences.

PDFs of these articles are available to credentialed media outlets upon request. Contact jhronek@slas.org.

About our Society and Journals

SLAS (Society for Laboratory Automation and Screening) is an international community of nearly 20,000 professionals and students dedicated to life sciences discovery and technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building.

SLAS DISCOVERY:2016 Impact Factor 2.355. Editor-in-Chief Robert M. Campbell, Ph.D., Eli Lilly and Company, Indianapolis, IN (USA). SLAS Discovery (Advancing Life Sciences R&D) was previously published (1996-2016) as the Journal of Biomolecular Screening (JBS).

SLAS TECHNOLOGY: 2016 Impact Factor 2.632. Editor-in-Chief Edward Kai-Hua Chow, Ph.D., National University of Singapore (Singapore). SLAS Technology (Translating Life Sciences Innovation) was previously published (1996-2016) as the Journal of Laboratory Automation (JALA).

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SLAS (Society for Laboratory Automation and Screening)

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