Nav: Home

Breast density research edges closer to cancer prevention

January 24, 2017

Adelaide researchers are one step closer to breast cancer prevention after finding a new driver for breast density, an identified risk factor for breast cancer.

For the first time, researchers have shown that chronic low-level inflammation drives increased breast density and is associated with a woman's risk of developing breast cancer.

This finding opens the door for new approaches to treating density and preventing breast cancer through reducing inflammation.

Published this month in the international journal Breast Cancer Research, the research is led by The Hospital Research Foundation's (THRF) Breast Cancer Research Fellow, Associate Professor Wendy Ingman from the University of Adelaide.

"We induced a low level of chronic inflammation in our lab models and found it was a particular protein called CCL2 that caused the increase in inflammation. This led to an increase in the density in the tissue and also an increased risk of breast cancer," Associate Professor Ingman said.

"While it is already known that certain types of anti-inflammatories (such as aspirin) can reduce breast cancer risk, they are associated with longer term side effects and not recommended for women to help reduce their breast cancer risk.

"With this research we believe we may be able to identify the women most at risk of inflammation-associated breast cancer through measuring their breast density and therefore identify those who will most benefit from anti-inflammatory treatment," Associate Professor Ingman said.

Almost 8% of women have extremely high breast density and are more likely to develop breast cancer in the future.

"Our ultimate aim is to save women's lives and our breast density research is helping us learn more about what drives this area of breast cancer risk to help inform preventative treatments," Associate Professor Ingman said.

"The more we can understand the risks associated with breast cancer, the greater chance we have at treating each risk and preventing breast cancer from developing in women.

"The next step is to conduct further studies into which treatments are best to dampen the inflammation, and to look at the relationship between density and inflammation within a large population of women."

THRF Chief Executive Officer Paul Flynn said this research, supported by the local community, is essential to understanding breast density and why it is an identified risk factor of breast cancer.

"With the help of our generous donors and ticket buyers in the Hospital Research Home Lottery, we're very proud to support Associate Professor Ingman's vital research aimed at preventing breast cancer for women in the future," he said.

Dr Alessandra Muntoni, Director of Research Investment, National Breast Cancer Foundation said that more details on the association of breast density with breast cancer are emerging as researchers learn more about this complex disease.

"We welcome research that brings further light to risk factors for breast cancer and breast density with the ultimate view of tailoring screening and preventing breast cancer," she said.
-end-
The research was funded by The Hospital Research Foundation and the National Breast Cancer Foundation.

Media Contacts

Associate Professor Wendy Ingman, THRF Breast Cancer Research Fellow, The University of Adelaide, Lead Researcher, Breast Biology and Cancer Unit, Basil Hetzel Institute for Translational Health Research, Robinson Research Institute, +61 (0)413 341 258, wendy.ingman@adelaide.edu.au

Abbey Flanagan, Communications Manager, The Hospital Research Foundation Phone: +61 8 7002 0804, Mobile: +61 (0)401 082 124, AFlanagan@hospitalresearch.com.au

Robyn Mills, Media and Communications Officer, The University of Adelaide Phone: +61 8 8313 5808, Mobile: +61 (0)410 689 084, robyn.mills@adelaide.edu.au

University of Adelaide

Related Breast Cancer Articles:

Does MRI plus mammography improve detection of new breast cancer after breast conservation therapy?
A new article published by JAMA Oncology compares outcomes for combined mammography and MRI or ultrasonography screenings for new breast cancers in women who have previously undergone breast conservation surgery and radiotherapy for breast cancer initially diagnosed at 50 or younger.
Blood test offers improved breast cancer detection tool to reduce use of breast biopsy
A Clinical Breast Cancer study demonstrates Videssa Breast can inform better next steps after abnormal mammogram results and potentially reduce biopsies up to 67 percent.
Surgery to remove unaffected breast in early breast cancer increases
The proportion of women in the United States undergoing surgery for early-stage breast cancer who have preventive mastectomy to remove the unaffected breast increased significantly in recent years, particularly among younger women, and varied substantially across states.
Breast cancer patients with dense breast tissue more likely to develop contralateral disease
Breast cancer patients with dense breast tissue have almost a two-fold increased risk of developing disease in the contralateral breast, according to new research from The University of Texas MD Anderson Cancer.
Some early breast cancer patients benefit more from breast conservation than from mastectomy
Breast conserving therapy (BCT) is better than mastectomy for patients with some types of early breast cancer, according to results from the largest study to date, presented at ECC2017.
More Breast Cancer News and Breast Cancer Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Anthropomorphic
Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#534 Bacteria are Coming for Your OJ
What makes breakfast, breakfast? Well, according to every movie and TV show we've ever seen, a big glass of orange juice is basically required. But our morning grapefruit might be in danger. Why? Citrus greening, a bacteria carried by a bug, has infected 90% of the citrus groves in Florida. It's coming for your OJ. We'll talk with University of Maryland plant virologist Anne Simon about ways to stop the citrus killer, and with science writer and journalist Maryn McKenna about why throwing antibiotics at the problem is probably not the solution. Related links: A Review of the Citrus Greening...