Nav: Home

Scientists culture human placenta stem cells for first time

January 24, 2018

In a milestone achievement for better understanding the development and function of the human placenta, scientists have derived and grown trophoblast stem cells for the first time.

Led by Takahiro Arima, a professor of informative genetics at the Tohoku University School of Medicine in Japan, the research team published their results in Cell Stem Cell, a journal published by the International Society for Stem Cell Research. The team also includes scientists from the Medical Institute of Bioregulation at Kyushu University,

"Trophoblast cells play an essential role in the interactions between the fetus and mother," wrote Arima. These cells form the outer layer of the blastocyst, which eventually develops into an embryo and into a fetus. Trophoblast cells become the placenta, providing nutrients to the fetus and taking away waste.

Too few or too many trophoblast cells can mean disaster for the fetus and mother. An imbalance of trophoblast cells can lead to miscarriage in early pregnancy, or preeclampsia and other conditions later on. That is why it is important to study human trophoblast development and function, wrote Arima. "In our paper, our goal was to establish human trophoblast stem cells [as a tool for future study]."

The researchers derived trophoblast stem cells from human volunteers with approval from the Ethics Committee of Tohoku University School of Medicine. The cells were then transferred to a growth medium to proliferate, but the cells died off.

Using genetic sequencing, Arima and his team found that the cells needed certain proteins activated and others inhibited to stay alive and maintain the same characteristics they would have in utero.

Other cultured cell lines have been used as models of human trophoblast cells, according to Arima, yet those cells have drastically different protein expression than native trophoblast cells. Such differences could make it more difficult to determine disease origin or potential therapeutic targets.

"Our culture system for human trophoblast stem cells is potentially useful for understanding the pathogenesis of developmental disorders with trophoblast defects, such as miscarriage, preeclampsia and intrauterine growth restriction," Arima wrote, adding that the research team hopes the tool will be used for medical science, especially in the fields of etiology and new drug development to treat perinatal disease.
Acknowledgements: The research was funded by the Core Research for Evolutional Science and Technology (CREST) from the Japan Agency for Medical Research and Development (AMED).

Tohoku University

Related Preeclampsia Articles:

Stroke risk factors for pregnant women with preeclampsia uncovered
Researchers at Columbia University discovered that women with preeclampsia have a higher stroke risk during pregnancy and postpartum if they have urinary tract infections, chronic high blood pressure, or blood disorders.
Infections, other factors raise risk of pregnancy-related stroke in women with preeclampsia
Infections, chronic high blood pressure and bleeding or clotting disorders increase the risk of pregnancy-related stroke in women with preeclampsia.
Obese women less likely to suffer from dangerous preeclampsia complications
Despite having higher rates of preeclampsia, a dangerous high-blood pressure disorder of late pregnancy, obese women may be less than half as likely to suffer strokes, seizures, and other serious complications of the disorder.
Screening for preeclampsia in pregnant women recommended
The US Preventive Services Task Force (USPSTF) recommends screening for preeclampsia in pregnant women with blood pressure measurements throughout pregnancy.
Altered immune cells may both contribute to preeclampsia and offer new hope for treatment
In a new study presented today at the APS annual meeting at Experimental Biology 2017, researchers have found that the immune system's natural killer (NK) cells activate and change in response to placental ischemia.
Is preeclampsia a risk or a protective factor in retinopathy of prematurity?
Mary Elizabeth Hartnett, M.D., and colleagues at the John A.
Evaluation of recombinant antithrombin vs. placebo in preterm preeclampsia
Researchers with the PRESERVE-1 Study Group University of Texas Health Science Center at Houston -- McGovern Medical School, Houston, Texas, and Yale School of Medicine, New Haven, Conn., present findings of a study titled Randomized double-blind placebo controlled evaluation of the safety and efficacy of recombinant Antithrombin versus placebo in preterm preeclampsia.
Potential treatment for pregnant women who suffer from preeclampsia found in a vitamin
Scientists in Japan and the US have found that vitamin B3 nicotinamide may help treat pregnant women who suffer from preeclampsia by preventing strokes and in some cases, even stimulating the growth of their fetus.
Increases in sFLT1 predict the onset of preeclampsia symptoms in mice
In this month's issue of the JCI, work led by Ananth Karumanchi determined that elevating levels of a protein called soluble fms-like tyrosine kinase 1 (sFLT1) produced preeclampsia-like symptoms in pregnant mice.
A urine sample could be used to diagnose a complex and serious pregnancy disorder
Scientists from MIPT in collaboration with researchers from a number of other institutes have developed a non-invasive method to diagnose preeclampsia -- a complex condition which occurs during pregnancy.

Related Preeclampsia Reading:

Preeclampsia: Basic, Genomic, and Clinical (Comprehensive Gynecology and Obstetrics)
by Shigeru Saito (Editor)

This volume is an excellent guide that comprehensively illustrates hypertensive disorders of pregnancy, especially preeclampsia, in both the basic and clinical aspects.

Preeclampsia is a pregnancy-specific multi-organ disorder and a leading cause of maternal and neonatal mortality. The pathophysiology of pregnancy-specific disorders was long unknown, but recently many new findings have been reported from the point of view of pathophysiology. Furthermore, this complication of pregnancy, especially preeclampsia, is a potent risk factor for chronic conditions such as cardiovascular... View Details

Pregnancy After Preeclampsia

````````````The true story of a mother's battle with Preeclampsia```````````````

I stare as they carry her across the room and lay her lifeless, six-pound body in a glass crib. The nurses look hopeless as they shove a tiny mask over her face, forcing oxygen into her lungs. Pain in my uterus grabs my attention as my OBGYN massages it with a clenched fist. Shawn stands by my head, torn between the two of us. We both need him, but I shove him toward her. She's clinging to life, unable to breathe, surrounded by strange voices and bright lights. Her first memory of the world will be... View Details

Preeclampsia: Methods and Protocols (Methods in Molecular Biology)
by Padma Murthi (Editor), Cathy Vaillancourt (Editor)

This volume presents the latest developments and techniques used to study the physiopathology, diagnosis, and treatment of pre-eclampsia. Written for clinicians, obstetricians, basic scientists, researchers, and students the chapters in this book provide methods to study placental function using in vitro and ex vivo model systems, comprehensive genetic analysis of pre-eclampsia, identifying critical angiogenic factors associated with the development of pre-eclampsia, and controlled experiments that investigate potential therapies. Written in the highly successful Methods in Molecular... View Details

PREECLAMPSIA: HELLP Syndrome, Eclampsia and other Hypertensive Disorders of Pregnancy

Your pregnancy guide to common life threatening complications. Discover proven ways to protect yourself and loved ones.

Are you looking after your pregnancy like it is 1945? Preeclampsia is common than you think!

Every pregnancy and childbirth is a precious journey into motherhood. What you don’t know may badly hurt you and your baby.

Do you know 6 preeclampsia symptoms you should never ignore?7 Healthy Ways to turn your pregnancy stress to pregnancy strength.Essential treatment every pregnant woman should know about.Do you know why... View Details

Storm of Hope: God, Preeclampsia, Depression, and me
by Leila Tualla (Author)

I love the life I live
I love the life I live
if I say it over and over again,
Maybe I'll live the life I love.
Author and Poet, Leila Tualla, chronicles her pregnancy journey riddled with anxiety, a preeclampsia diagnosis, and later postpartum depression in Storm of Hope: God, Preeclampsia, Depression and me. This memoir is told in journal entries and poetry. View Details

Pre-eclampsia: Current Perspectives on Management
by Philip Baker (Editor), John C. P. Kingdom (Editor)

With its life-threatening implications for both mothers and babies, pre-eclampsia continues to be one of the medical communities greatest challenges. The extremely variable clinical presentations reflect the complexity of the underlying pathology. Edited by renowned experts, Pre-Eclampsia: Current Perspectives on Management presents a comprehensive overview of the condition.

Beginning with a historical review, the book covers current perspectives on the etiology of the condition including genetic aspects, the role of trophoblast invasion, the placenta, and the widespread endothelial... View Details

A Handful of Hope: A Mom and Dad's Guide to Preeclampsia
by David Papandreas (Author)

A Handful of Hope: A Mom and Dad's Guide to Preeclampsia is the first book ever written to help parents navigate through the trials of preeclampsia. We have geared this book for both moms and dads to offer helpful tips to having a happy and successful pregnancy. This book is a must read for anyone who has been diagnosed with preeclampsia. We are proud to be donating 10% of all profits to fund Preeclampsia Research to help find a cure. *This is the newest revised edition and now includes a full 30-Day Meal Plan View Details

Focus On: 100 Most Popular Medical Emergencies: Outline of emergency Medicine, Sepsis, Myocardial Infarction, Meningitis, Addison's Disease, Appendicitis, ... Pre-eclampsia, Cardiac Arrest, etc.
by Focus On

This carefully crafted ebook is formatted for your eReader with a functional and detailed table of contents. The Focus On books are made out of collections of Wikipedia articles regrouping the most informative and popular articles about a specific subject. The Focus On books are a result of a substantial editorial work of selecting and grouping relevant articles together in order to create a valuable source of information about specific subjects. This book does not contain tables, illustrations or illustration descriptions. Focus On (an imprint of OK Publishing) charges for the convenience... View Details

Pre-eclampsia: Etiology and Clinical Practice (Cambridge Medicine (Hardcover))
by Fiona Lyall (Editor), Michael Belfort (Editor)

Pre-eclampsia is one of the leading causes of death and disability in mothers and babies. Over four million women worldwide will develop the disorder every year. This book, written by an international team of experts, focuses on both the scientific basis of pre-eclampsia and its management. The basic science section contains reviews of the most exciting research developments in pre-eclampsia. The clinical chapters provide a comprehensive review of the pertinent literature, highlighting data and ideas or developments in management. There is a section in each chapter (where relevant) that deals... View Details

Best Science Podcasts 2018

We have hand picked the best science podcasts for 2018. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Attention Please
In an age of constant information and infinite distractions, how can we pay more attention to our ... attention? This hour, TED speakers explore the battle for our awareness during the digital age. Guests include sociologist Zeynep Tufekci, podcast host Manoush Zomorodi, neuroscientist Amishi Jha, designer Tristan Harris, and computer scientist Jaron Lanier.
Now Playing: Science for the People

#475 Mother Nature is Trying to Kill You (Rebroadcast)
This week, we're learning how deadly and delightful our planet and its ecosystem can be. We're joined by biologist Dan Riskin, co-host of Discovery Canada's Daily Planet, to talk about his book "Mother Nature Is Trying to Kill You: a Lively Tour Through the Dark Side of the Natural World." And we'll talk to astronomer and author Phil Plait about Science Getaways, his company that offers educational vacation experiences for science lovers.