Elevated risk factors linked to major cardiovascular disease events across a lifetime

January 25, 2012

In one of the largest-ever analyses of lifetime risks for cardiovascular disease (CVD), researchers have found that middle-aged adults who have one or more elevated traditional risk factors for CVD, such as high blood pressure, have a substantially greater chance of having a major CVD event, such as heart attack or stroke, during their remaining lifetime than people with optimal levels of risk factors. This National Institutes of Health-supported study used health data from 257,384 people and was the first to look simultaneously at multiple risk factors for CVD across age, sex, race, and birth generation.

The paper will be published in the January 26 issue of the New England Journal of Medicine.

"This paper adds to the substantial body of evidence that modifiable cardiovascular disease risk factors in healthy men and women heavily influence the likelihood of developing cardiovascular disease later in life, regardless of their backgrounds," said Susan B. Shurin, M.D., acting director of the NIH's National Heart, Lung, and Blood Institute.

"Prevention of cardiovascular disease is a lifetime opportunity for and a responsibility of individuals, families, communities, and the health care system. This paper reinforces that cardiovascular disease can be prevented and controlled throughout the course of an adult's lifetime," she added.

As part of the Cardiovascular Lifetime Risk Pooling Project, investigators analyzed 50 years of data from 18 existing cohort, or population-based, studies in the United States. The investigators pooled the data from the 18 cohorts and measured traditional CVD risk factors - including high blood pressure, high cholesterol levels, diabetes, and smoking status - in men and women from both black and white populations at ages 45, 55, 65, and 75 years.

Men who were 55 years old with at least two major risk factors were six times as likely to die from CVD by age 80 as were men with none or one CVD risk factor (29.6 percent vs. 4.7 percent). Women with at least two major risk factors were three times as likely to die from CVD as were women with no or one CVD risk factor (20.5 percent vs. 6.4 percent).

When all CVD events - fatal and non-fatal - were considered, the results were even more striking. Forty-five-year-old men with two or more risk factors had a 49.5 percent chance of having a major CVD event through age 80, while 45-year-old women had a 30.7 percent chance. On the other hand, men with optimal risk factor levels only had a 1.4 percent chance of having a major CVD event, while women had a 4.1 percent chance of having a major CVD event through age 80.

The results from each individual study were consistent with one another and with those of the pooled group, and showed that traditional risk factors predicted a person's long-term development of CVD more than age. All of the risk factors appeared to carry the same levels of risk as they did 20, 30, or 40 years ago. While black Americans had a higher prevalence of CVD risk factors than white Americans, their lifetime risks were similar when their risk factor profiles were similar.

"In general, previous studies have only looked at CVD risk factors across one specific age or gender in white populations," said Donald M. Lloyd-Jones, M.D., principal investigator of the study and an associate professor and chair of the Department of Preventive Medicine at Northwestern University Feinberg School of Medicine in Chicago. "We analyzed an enormous pool of available data, which allowed for a more precise estimate of lifetime CVD risks across the age, sex, race, and risk factor spectrum."

Lloyd-Jones added, "These data have important implications for prevention. We need to get more serious about promoting healthy lifestyles in children and young adults, since even mild elevations in risk factors by middle age seem to have profound effects on the remaining lifetime risks for CVD."

The NHLBI supported several of the cohort studies involved, including the Atherosclerosis Risk in Communities Study, Cardiovascular Heart Study, Framingham Heart Study, Framingham Offspring Study, Honolulu Heart Program, Puerto Rico Heart Health Program, and Women's Health Initiative.

"This paper illustrates the power of pooling data from epidemiological studies," said Michael Lauer, M.D., director of the NHLBI's Division of Cardiovascular Sciences. "Because of the U.S. government's investments in these studies, it was possible for the investigators to gather and analyze data on over a quarter of a million people, which could lead to substantial public health and clinical practice implications."

"It is important for adults to know their blood pressure and cholesterol numbers and whether they are at risk for diabetes and also to understand the different approaches they can take to prevent or control their risks for CVD. As American Heart Month approaches in February, this paper underscores the importance of raising awareness of heart disease and coronary heart disease - the most common type of heart disease and the number one killer of both men and women in the United States," said Lloyd-Jones and Shurin.

In an effort to help people reduce their risks of cardiovascular disease, the Centers for Disease Control and Prevention and the Centers for Medicare and Medicaid Services recently launched the Million Hearts Campaign, a national initiative to prevent 1 million heart attacks and strokes over the next five years.

Also, in December 2010, in an effort to promote healthy behaviors and prevent diseases, including cardiovascular disease, the U.S. Department of Health and Human Services launched Healthy People 2020. Healthy People 2020 and its specific, measurable health objectives represent the nation's disease prevention and health promotion goals for the coming decade.
For additional information or to arrange an interview with an NHLBI spokesperson, please contact the NHLBI Communications Office at 301-496-4236 or nhlbi_news@nhlbi.nih.gov.

To arrange an interview with Dr. Lloyd-Jones, contact Marla Paul at the Northwestern University Feinberg School of Medicine at 312-503-8928.

Resources: Part of the National Institutes of Health, the National Heart, Lung, and Blood Institute (NHLBI) plans, conducts, and supports research related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases; and sleep disorders. The Institute also administers national health education campaigns on women and heart disease, healthy weight for children, and other topics. NHLBI press releases and other materials are available online at www.nhlbi.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

NIH...Turning Discovery Into Health

NIH/National Heart, Lung and Blood Institute

Related Heart Disease Articles from Brightsurf:

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure.

Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery.

New 'atlas' of human heart cells first step toward precision treatments for heart disease
Scientists have for the first time documented all of the different cell types and genes expressed in the healthy human heart, in research published in the journal Nature.

With a heavy heart: How men and women develop heart disease differently
A new study by researchers from McGill University has uncovered that minerals causing aortic heart valve blockage in men and women are different, a discovery that could change how heart disease is diagnosed and treated.

Heart-healthy diets are naturally low in dietary cholesterol and can help to reduce the risk of heart disease and stroke
Eating a heart-healthy dietary pattern rich in vegetables, fruits, whole grains, low-fat dairy products, poultry, fish, legumes, vegetable oils and nuts, which is also limits salt, red and processed meats, refined-carbohydrates and added sugars, is relatively low in dietary cholesterol and supports healthy levels of artery-clogging LDL cholesterol.

Pacemakers can improve heart function in patients with chemotherapy-induced heart disease
Research has shown that treating chemotherapy-induced cardiomyopathy with commercially available cardiac resynchronization therapy (CRT) delivered through a surgically implanted defibrillator or pacemaker can significantly improve patient outcomes.

Arsenic in drinking water may change heart structure raising risk of heart disease
Drinking water that is contaminated with arsenic may lead to thickening of the heart's main pumping chamber in young adults, according to a new study by researchers at Columbia University Mailman School of Public Health.

New health calculator can help predict heart disease risk, estimate heart age
A new online health calculator can help people determine their risk of heart disease, as well as their heart age, accounting for sociodemographic factors such as ethnicity, sense of belonging and education, as well as health status and lifestyle behaviors.

Wide variation in rate of death between VA hospitals for patients with heart disease, heart failure
Death rates for veterans with ischemic heart disease and chronic heart failure varied widely across the Veterans Affairs (VA) health care system from 2010 to 2014, which could suggest differences in the quality of cardiovascular health care provided by VA medical centers.

Heart failure: The Alzheimer's disease of the heart?
Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure, according to a team led by Johns Hopkins University researchers.

Read More: Heart Disease News and Heart Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.