An important LINC in human hearing

January 25, 2013

In this issue of the Journal of Clinical Investigation, Karen Avraham and colleagues at Tel Aviv University identified a genetic mutation in two families with hereditary high frequency hearing loss. The mutated gene, which has not previously been linked to hearing loss, encodes NESP4, a protein that is expressed in the outer nuclear membrane (ONM) of the hair cells of the ear. Avraham and colleagues found that mutated NESP4 was mislocalized, disrupting a cellular complex known as the "linker of nucleoskeleton and cytoskeleton" or LINC, which maintains the position of the nucleus within the cell. Hair cells in mice lacking NESP4 or another component of the LINC complex, SUN1, developed normally, but the mice developed hearing loss as they matured. These results demonstrate that the LINC complex is essential for hearing and indicate that nuclear positioning is important for the maintenance of normal hearing. In a companion commentary, Howard Worman of Columbia University discusses the role of the LINC complex in physiology and disease.

The LINC complex is essential for hearing


Karen B. Avraham
Tel Aviv University
Tel Aviv, UNK, ISR
Phone: 972-3-640-6642
Fax: 972-3-640-9360

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Nucleocytoplasmic connections and deafness


Howard Worman
Columbia University College of Physcians and Surgeons
New York, NY, USA
Phone: 212-305-1306
Fax: 212 305-6443
E-mail: hjw14@columbia.eduView this article at:

JCI Journals

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