Nav: Home

Therapeutic hypothermia offers no significant benefits for infants or children after in-hospital car

January 25, 2017

WHAT: In a multicenter, international study of infants and children who suffered cardiac arrest while in the hospital, NIH-funded researchers have found that body cooling, or therapeutic hypothermia, is no more effective than actively keeping the body at a normal temperature, or therapeutic normothermia.

The study is the first to look exclusively at in-hospital cardiac arrests in infants and children in order to compare the two temperature treatments. Earlier trials involving adults who went into cardiac arrest outside of a hospital had found that therapeutic hypothermia improved survival and brain function. However, recent trials in adults and children did not find such improvements when compared with patients whose temperature was actively maintained in a normal temperature range to prevent fever.

Current guidelines recommend either treatment for out-of-hospital cardiac arrests in children, as both methods have resulted in equal rates of survival and prevention of brain injury. But out-of-hospital cardiac arrests have different causes and outcomes than in-hospital ones, and the findings of the new study could inform new guidelines for treatment of the latter.

The study included 329 patients between the ages of 2 days and 18 years old who had sustained cardiac arrest while in a hospital. The researchers randomly divided them into two groups and found that children in the group treated with therapeutic hypothermia had the same survival rates and neurobehavioral functioning a year later as those treated by keeping the body at normal temperature.

The research--funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health--was presented at the annual meeting of the Society for Critical Care Medicine and published simultaneously in the January 24 issue of the New England Journal of Medicine.

The study is part of the Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) trials, the largest examination to date of therapeutic hypothermia in children other than newborns for any health condition.
-end-
WHO: Jonathan R. Kaltman, M.D., medical officer in the Heart Development and Structural Diseases Branch in the Division of Cardiovascular Sciences at the National Heart, Lung, and Blood Institute (NHLBI), is available to comment.

ARTICLE: F Moler et al. Therapeutic Hypothermia After In-Hospital Pediatric Cardiac Arrest in Children. New England Journal of Medicine. DOI: 10.1056/NEJMoa1610493

CONTACT: For more information or to schedule an interview, please contact the NHLBI Office of Science Policy, Engagement, Education, and Communications at 301-496-5449 or nhlbi_news@nhlbi.nih.gov (link sends e-mail)

Part of the National Institutes of Health, the National Heart, Lung, and Blood Institute (NHLBI) plans, conducts, and supports research related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases; and sleep disorders. The Institute also administers national health education campaigns on women and heart disease, healthy weight for children, and other topics. NHLBI press releases and other materials are available online at http://www.nhlbi.nih.gov.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIH...Turning Discovery Into Health

NIH/National Heart, Lung and Blood Institute

Related Cardiac Arrest Articles:

Bystanders can help more cardiac arrest victims survive
Only 8% of Americans survive cardiac arrest outside a hospital, but that percentage could increase significantly if bystanders recognize cardiac arrest and perform simple lifesaving tasks, a UVA Health physician says in a New England Journal of Medicine article.
Opioid-related cardiac arrest patients differ from other cardiac arrests
People who suffer cardiac arrest due to an opioid overdose are younger, have fewer chronic medical conditions and may be more likely to be to receive bystander CPR, according to a review of emergency response records in Maine.
Selective coronary angiography following cardiac arrest
In the current issue of Cardiovascular Innovations and Applications volume 4, issue 2, pp.
Sudden cardiac arrest in athletes: Prevention and management
It's marathon season, and every so often a news report will focus on an athlete who has collapsed from sudden cardiac arrest.
Scientific statement on predicting survival for cardiac arrest survivors
If a loved one has a heart attack that stops the heart, ends up in a coma, and the treating physician approaches you about taking the person off life support, would you trust that the physician knows when to make the call or how to judge that the person won't recover?
Cardiac arrest among hospitalized patients may be underestimated
More patients may be having cardiac arrests in the hospital than previously believed.
Women are less likely to be resuscitated and survive a cardiac arrest than men
Women who have a cardiac arrest outside the hospital setting are less likely to receive resuscitation from bystanders and more likely to die than men, according to new research published in the European Heart Journal.
Compression-only CPR increases survival of out-of-hospital cardiac arrest
In a Swedish study of out-of-hospital cardiac arrest, bystander CPR rates nearly doubled and compression-only, or Hands-Only CPR, rates increased six-fold over the 18-year review.
Black infants may have higher cardiac arrest rates
Black infants were significantly more likely to suffer cardiac arrest than White or Hispanic children in a review of emergency response records in the Houston area.
New and better marker for assessing patients after cardiac arrest
Last year, researchers Tobias Cronberg and Niklas Mattsson at Lund University in Sweden published a study showing serum tau levels to be a new and promising marker for identifying patients with severe brain damage after cardiac arrest.
More Cardiac Arrest News and Cardiac Arrest Current Events

Top Science Podcasts

We have hand picked the top science podcasts of 2019.
Now Playing: TED Radio Hour

In & Out Of Love
We think of love as a mysterious, unknowable force. Something that happens to us. But what if we could control it? This hour, TED speakers on whether we can decide to fall in — and out of — love. Guests include writer Mandy Len Catron, biological anthropologist Helen Fisher, musician Dessa, One Love CEO Katie Hood, and psychologist Guy Winch.
Now Playing: Science for the People

#543 Give a Nerd a Gift
Yup, you guessed it... it's Science for the People's annual holiday episode that helps you figure out what sciency books and gifts to get that special nerd on your list. Or maybe you're looking to build up your reading list for the holiday break and a geeky Christmas sweater to wear to an upcoming party. Returning are pop-science power-readers John Dupuis and Joanne Manaster to dish on the best science books they read this past year. And Rachelle Saunders and Bethany Brookshire squee in delight over some truly delightful science-themed non-book objects for those whose bookshelves are already full. Since...
Now Playing: Radiolab

An Announcement from Radiolab