Nav: Home

Quadrivalent influenza vaccine should reduce medical costs and save lives

January 25, 2017

Influenza is one of the biggest public health concerns, accounting for up to 5 million severe cases and half a million deaths every year worldwide. Therefore, vaccination against influenza has been a part of immunization programs throughout the world. While the most widely used vaccine is the trivalent influenza vaccine (TIV), the World Health Organization has been recommending the quadrivalent influenza vaccine (QIV) as of 2013.

A study just published in Human Vaccines & Immunotherapeutics suggests that QIV might bring clinical benefits and cost savings over TIV if used on a large scale.

There are four influenza strains in circulation that cause the majority of cases: two of type A and two of type B. TIV contains both type A strains and one type B, which are determined prior to the influenza season every year. QIV, which includes all four strains, was developed with the aim to provide broader protection with lower variability from season to season.

Researchers modelled the impact that QIV would have had if it had been used instead of TIV in recent years in three Latin American countries. They estimated the numbers of influenza cases, doctor's visits and associated work absenteeism, hospitalizations and deaths due to influenza, as well as associated costs.

"Our study provides the first quantitative estimates of the potential benefits of QIV should it replace TIV in the national immunization programs in Brazil, Colombia and Panama. We found that QIV would provide health benefits in the three countries when considering influenza circulation from the last seasons. For instance, an annual average of 120,000 influenza cases would be avoided with QIV in the targeted population in Brazil, avoiding in turn about 2,350 hospitalizations and 275 deaths," says the lead author Aurélien Jamotte of Creativ-Ceutical.

The total societal cost savings were estimated between $1,000 and $34,000 per 100,000 person-years.

"We hope our study will be particularly useful for policy makers since its scope has been based on the current national recommendations of Brazil, Colombia and Panama. This study also provides the first quantitative estimates on the additional public health and economic impact of QIV when included in the national immunization programs," according to Aurélien Jamotte.

These results are in agreement with similar modelling studies from Europe and Australia.

"QIV is expected to provide benefits in most parts of the world since B strains represent on average 20-30% of circulating strains around the world. These proportions can be as high as 87% during some seasons in some countries. Whatever the country considered, QIV is expected to further reduce the public health and economic burden of influenza compared with TIV," concludes Aurélien Jamotte.
-end-


Taylor & Francis Group

Related Influenza Articles:

Obesity promotes virulence of influenza
Obesity promotes the virulence of the influenza virus, according to a study conducted in mice published in mBio, an open-access journal of the American Society for Microbiology.
Influenza: combating bacterial superinfection with the help of the microbiota
Frenc researchers and from Brazilian (Belo Horizonte), Scottish (Glasgow) and Danish (Copenhagen) laboratories have shown for the first time in mice that perturbation of the gut microbiota caused by the influenza virus favours secondary bacterial superinfection.
Chemists unveil the structure of an influenza B protein
MIT chemists have discovered the structure of an influenza B protein called BM2, a finding that could help researchers design drugs that block the protein and help prevent the virus from spreading.
How proteins help influenza A bind and slice its way to cells
Researchers have provided new insight on how two proteins help influenza A virus particles fight their way to human cells.
Eating elderberries can help minimize influenza symptoms
Conducted by Professor Fariba Deghani, Dr. Golnoosh Torabian and Dr.
Mechanism to form influenza A virus discovered
A new study by Maria João Amorim's team, from the Gulbenkian Institute of Science, now reveals where the genomes of the influenza A virus are assembled inside infected cells.
Bat influenza viruses could infect humans
Bats don't only carry the deadly Ebola virus, but are also a reservoir for a new type of influenza virus.
New VaxArray publication on influenza neuraminidase quantification
InDevR Inc. announced publication of 'A Neuraminidase Potency Assay for Quantitative Assessment of Neuraminidase in Influenza Vaccines' in npj Vaccines.
Fighting mutant influenza
Another flu season is here, which means another chance for viruses to mutate.
Influenza vaccine delays are a problem for pediatricians
Uptake of influenza vaccine among children is low compared to other childhood vaccines, and missed opportunities for vaccination play an important role in this low uptake.
More Influenza News and Influenza Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Teaching For Better Humans 2.0
More than test scores or good grades–what do kids need for the future? This hour, TED speakers explore how to help children grow into better humans, both during and after this time of crisis. Guests include educators Richard Culatta and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#556 The Power of Friendship
It's 2020 and times are tough. Maybe some of us are learning about social distancing the hard way. Maybe we just are all a little anxious. No matter what, we could probably use a friend. But what is a friend, exactly? And why do we need them so much? This week host Bethany Brookshire speaks with Lydia Denworth, author of the new book "Friendship: The Evolution, Biology, and Extraordinary Power of Life's Fundamental Bond". This episode is hosted by Bethany Brookshire, science writer from Science News.
Now Playing: Radiolab

Space
One of the most consistent questions we get at the show is from parents who want to know which episodes are kid-friendly and which aren't. So today, we're releasing a separate feed, Radiolab for Kids. To kick it off, we're rerunning an all-time favorite episode: Space. In the 60's, space exploration was an American obsession. This hour, we chart the path from romance to increasing cynicism. We begin with Ann Druyan, widow of Carl Sagan, with a story about the Voyager expedition, true love, and a golden record that travels through space. And astrophysicist Neil de Grasse Tyson explains the Coepernican Principle, and just how insignificant we are. Support Radiolab today at Radiolab.org/donate.