Approaching a stem cell therapy for Parkinson's disease

January 26, 2006

High hopes have been pinned on the prospects of using stem cells to eventually be able to replace diseased or dead cells with new, healthy ones. In order to do this, the stem cells must be programmed to form cells with the exact speciality needed for the treatment of patients.

Parkinson's Disease is caused by the degeneration of dopamine-producing cells in a certain part of the brain. By studying the embryonic development of the central nervous system, research groups led by Johan Ericson and Thomas Perlmann at Karolinska Institutet have been able to show that two genes, Lmx1a and Msx1, play a critical part in the formation of cerebral dopamine cells. They also demonstrate how these findings can be used to control the formation of dopamine-producing cells from stem cells in a highly effective manner. This represents an important step in the development of a stem-cell based treatment for Parkinson's Disease.
-end-
Publication:
Identification of intrinsic determinants of midbrain dopamine neurons
Andersson E, Marklund U, Deng Q, Friling S, Alekseenko Z, Robert B, Perlmann T, Ericson J.
Cell 27 January 2006


Fore more information, please contact: Professor Johan Ericson, Karolinska Institutet, phone 46-85-248-7334, 4-670-378-7334, johan.ericson@ki.se

Professor Thomas Perlmann, Karolinska Institutet, phone 46-85-248-7106, 46-70-680-5057, thomas.perlmann@licr.ki.se

Karolinska Institutet

Related Stem Cells Articles from Brightsurf:

SUTD researchers create heart cells from stem cells using 3D printing
SUTD researchers 3D printed a micro-scaled physical device to demonstrate a new level of control in the directed differentiation of stem cells, enhancing the production of cardiomyocytes.

More selective elimination of leukemia stem cells and blood stem cells
Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia.

Computer simulations visualize how DNA is recognized to convert cells into stem cells
Researchers of the Hubrecht Institute (KNAW - The Netherlands) and the Max Planck Institute in Münster (Germany) have revealed how an essential protein helps to activate genomic DNA during the conversion of regular adult human cells into stem cells.

First events in stem cells becoming specialized cells needed for organ development
Cell biologists at the University of Toronto shed light on the very first step stem cells go through to turn into the specialized cells that make up organs.

Surprising research result: All immature cells can develop into stem cells
New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development.

The development of brain stem cells into new nerve cells and why this can lead to cancer
Stem cells are true Jacks-of-all-trades of our bodies, as they can turn into the many different cell types of all organs.

Healthy blood stem cells have as many DNA mutations as leukemic cells
Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ.

New method grows brain cells from stem cells quickly and efficiently
Researchers at Lund University in Sweden have developed a faster method to generate functional brain cells, called astrocytes, from embryonic stem cells.

NUS researchers confine mature cells to turn them into stem cells
Recent research led by Professor G.V. Shivashankar of the Mechanobiology Institute at the National University of Singapore and the FIRC Institute of Molecular Oncology in Italy, has revealed that mature cells can be reprogrammed into re-deployable stem cells without direct genetic modification -- by confining them to a defined geometric space for an extended period of time.

Researchers develop a new method for turning skin cells into pluripotent stem cells
Researchers at the University of Helsinki, Finland, and Karolinska Institutet, Sweden, have for the first time succeeded in converting human skin cells into pluripotent stem cells by activating the cell's own genes.

Read More: Stem Cells News and Stem Cells Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.