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For breast cancer patients, never too late to quit smoking

January 26, 2016

Documenting that it's never too late to quit smoking, a large study of breast cancer survivors has found that those who quit smoking after their diagnosis had a 33 percent lower risk of death as a result of breast cancer than those who continued to smoke.

The study involved more than 20,600 women with breast cancer, and is one of the largest studies of survival outcomes according to smoking habits in women with a history of breast cancer, and the first study to assess smoking habits both before and after diagnosis.

The paper was published in the Journal of Clinical Oncology on January 25, 2016.

"Our study shows the consequences facing both active and former smokers with a history of breast cancer," said first author Michael Passarelli, PhD, a cancer epidemiologist at the UCSF School of Medicine. "About one in ten breast cancer survivors smoke after their diagnosis. For them, these results should provide additional motivation to quit."

The findings come from the Collaborative Breast Cancer Study, conducted by the University of Wisconsin, Dartmouth College and Harvard University.

The observational study quantifies among women with breast cancer the long-term benefits of stopping smoking. The study, which followed participants on average a dozen years after diagnosis, compares the causes of death among four groups:
  • Women who never smoked;

  • Women who smoked and quit before diagnosis;

  • Women who smoked and quit after diagnosis;

  • Women who continued to smoke after diagnosis.

The 2014 Report of the Surgeon General on the health consequences of smoking suggested that there may be a causal relationship between breast cancer and smoking. Previous studies have also speculated that the risk of developing breast cancer in smokers might depend on when smoking started and for how long.

There are more than three million breast cancer survivors in the U.S.

Women in the Collaborative Breast Cancer Study were between the ages of 20 and 79, and were diagnosed with localized or invasive breast cancer between 1988 and 2008.

Participants were asked to report on such factors as whether they had smoked at least 100 cigarettes during their lifetime, their age when they started smoking, and the average number of cigarettes they smoked a day. The authors controlled for several important risk factors that could impact survival, including alcohol consumption and body mass index.

By 2010, a total of 6,778 women died - the leading causes of death were breast cancer and cardiovascular disease.

Active smokers a year before breast cancer diagnosis were more likely to die of breast cancer, respiratory cancer, other respiratory disease, or cardiovascular disease than women who had never smoked. The highest risks of death as a result of breast cancer were observed among long-term smokers, people who smoked heavily, or former smokers who quit fewer than five years before breast cancer diagnosis.

Approximately one in ten cancer patients continued to smoke following their diagnosis and they were more likely than people who had never smoked and former smokers to die of breast cancer, the researchers said. Those who quit smoking after diagnosis had lower mortality from breast cancer and respiratory cancer.

"Smoking cessation programs should be considered part of cancer therapy," Passarelli said. "Recent policy statements from leading research and clinical organizations are now urging oncologists to be as aggressive in getting their patients to stop smoking as they are in treating the cancer."

The study did not assess for exposure to second-hand smoke nor did it include hormone receptor status of breast tumors.
Co-authors are Polly Newcomb, PhD, MPH, of the Fred Hutchinson Cancer Research Center and University of Wisconsin School of Medicine and Public Health; John Hampton, MS, and Amy Trentham-Dietz, PhD, of the University of Wisconsin School of Medicine and Public Health; Linda Titus, PhD, of the Geisel School of Medicine at Dartmouth Medical School; Kathleen Egan, ScD, of the H. Lee Moffitt Cancer Center and Research Institute in Tampa; John Baron, MD, of the University of North Carolina School of Medicine in Chapel Hill; and Walter Willett, MD, DrPH, of Harvard T.H. Chan School of Public Health, Harvard Medical School and Brigham and Women's Hospital in Boston.

The study was funded by the National Cancer Institute (Grants R01CA47147, R01CA67264, R01CA47305, R01CA69664, R01CA82004, T32CA009168, R25CA112355, K05CA152714, P30CA014520, and P30CA015704) and Susan G. Komen for the Cure.

About UCSF: UC San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It includes top-ranked graduate schools of dentistry, medicine, nursing and pharmacy; a graduate division with nationally renowned programs in basic, biomedical, translational and population sciences; and a preeminent biomedical research enterprise. It also includes UCSF Health, which comprises top-ranked hospitals, UCSF Medical Center and UCSF Benioff Children's Hospitals in San Francisco and Oakland - and other partner and affiliated hospitals and healthcare providers throughout the Bay Area. Please visit

University of California - San Francisco

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