Nav: Home

Identified a determinant protein for tumor progression and metastasis in Rhabdomyos

January 29, 2020

Rhabdomyosarcoma is the most common childhood cancer in the soft tissues, and it is mainly originated in the muscles. It represents almost 5% of pediatric tumors, and the survival rate is between 60% and 70%. The work published in "Cancer Letters" journal focuses on the most aggressive and hard to treat rhabdomyosarcoma, the alveolar type. Metastasis plays an essential role in the disease progression, because it induces a severe decrease in patient survival rate, lower than 30%. Dr. Oscar M. Tirado's group from Bellvitge Biomedical Research Institute (IDIBELL) has observed that this type of sarcoma cells have an increased level of LOXL2 protein, that is implicated in tumors metastatic capacity.

In a normal situation, LOXL2 acts, outside the cell, modifying the surrounding extracellular matrix. However, in a tumor environment, LOXL2 acts inside the cell, promoting metastasis processes by a mechanism independent from its normal function. Dr. Olga Almacellas, the first author of the study, states that in future treatment, that tries to inhibit LOXL2 activity to reduce rhabdomyosarcoma metastasis, the drug penetration inside the cells must be considered. Besides, she adds that existing drugs that block the classic LOXL2 activity would not affect their metastatic role, as it is independent of its classical function.

Not only cellular models of alveolar rhabdomyosarcoma showed a clear decrease in metastatic capacity by LOXL2 elimination. Also, the injection of these cells into healthy mice demonstrated that those expressing LOXL2 formed more metastasis than those without it. Additionally, patients' samples, from the Virgen del Rocío University Hospital, suggested a lower survival rate for patients with higher levels of LOXL2. However, a more extensive study with more samples would be needed to confirm this relationship.

One of the questions that remains open is how LOXL2 regulates metastatic function in tumor cells. Researchers have found that it interacts with vimentin. A cytoskeletal protein that provides structural support, cell resistance and plays a crucial role in cell migration. Basics processes in metastasis.
-end-
This study was funded in part by the Alba Pérez Foundation fighting childhood cancer, the Carlos III Health Institute, the EU European Regional Development Fund (ERDF) and the SEARCH Program/Generalitat de Catalunya (2017SGR332).

IDIBELL-Bellvitge Biomedical Research Institute

Related Protein Articles:

Memory protein
When UC Santa Barbara materials scientist Omar Saleh and graduate student Ian Morgan sought to understand the mechanical behaviors of disordered proteins in the lab, they expected that after being stretched, one particular model protein would snap back instantaneously, like a rubber band.
Diets high in protein, particularly plant protein, linked to lower risk of death
Diets high in protein, particularly plant protein, are associated with a lower risk of death from any cause, finds an analysis of the latest evidence published by The BMJ today.
A new understanding of protein movement
A team of UD engineers has uncovered the role of surface diffusion in protein transport, which could aid biopharmaceutical processing.
A new biotinylation enzyme for analyzing protein-protein interactions
Proteins play roles by interacting with various other proteins. Therefore, interaction analysis is an indispensable technique for studying the function of proteins.
Substituting the next-best protein
Children born with Duchenne muscular dystrophy have a mutation in the X-chromosome gene that would normally code for dystrophin, a protein that provides structural integrity to skeletal muscles.
A direct protein-to-protein binding couples cell survival to cell proliferation
The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle.
A protein that controls inflammation
A study by the research team of Prof. Geert van Loo (VIB-UGent Center for Inflammation Research) has unraveled a critical molecular mechanism behind autoimmune and inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis.
Resurrecting ancient protein partners reveals origin of protein regulation
After reconstructing the ancient forms of two cellular proteins, scientists discovered the earliest known instance of a complex form of protein regulation.
Sensing protein wellbeing
The folding state of the proteins in live cells often reflect the cell's general health.
Protein injections in medicine
One day, medical compounds could be introduced into cells with the help of bacterial toxins.
More Protein News and Protein Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Warped Reality
False information on the internet makes it harder and harder to know what's true, and the consequences have been devastating. This hour, TED speakers explore ideas around technology and deception. Guests include law professor Danielle Citron, journalist Andrew Marantz, and computer scientist Joy Buolamwini.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

How to Win Friends and Influence Baboons
Baboon troops. We all know they're hierarchical. There's the big brutish alpha male who rules with a hairy iron fist, and then there's everybody else. Which is what Meg Crofoot thought too, before she used GPS collars to track the movements of a troop of baboons for a whole month. What she and her team learned from this data gave them a whole new understanding of baboon troop dynamics, and, moment to moment, who really has the power.  This episode was reported and produced by Annie McEwen. Support Radiolab by becoming a member today at Radiolab.org/donate.