Fas signaling and cardiac hypertrophy

January 30, 2002

Stimulation of Fas, the founding member of a family of dedicated cell surface "death receptors," activates one of the best studied routes to apoptosis. Evidence for Fas activation in cardiac myocytes subjected to pressure overload is therefore not surprising, but Badorff et al. have found that this protein subserves an unexpected role in these cells. As has been noted before, cardiac overexpression of the Fas ligand (FasL) does not kill myocytes but rather leads to a metabolic and morphological transition reminiscent of the adaptive hypertrophy. Working with cultured neonatal myocytes, Badorff and colleagues show that FasL treatment activates Akt, a protein kinase that has been extensively implicated in the hypertrophic response in the heart and elsewhere. Hypothesizing that Fas participates in the adaptive hypertrophy that allows the heart to compensate for pressure overload, the authors tested the effects of aortic banding in lpr mice, which are deficient in Fas. As predicted, these mice failed to compensate and often died within a week of the operation. Interestingly, mice lacking FasL showed no such defect, indicating that, although FasL can induce this response, Fas can be activated by other means during adaptive hypertrophy.
-end-


JCI Journals

Related Heart Articles from Brightsurf:

New 'atlas' of human heart cells first step toward precision treatments for heart disease
Scientists have for the first time documented all of the different cell types and genes expressed in the healthy human heart, in research published in the journal Nature.

Highly detailed map of the human heart could guide personalized heart treatments
Scientists have created a detailed cellular and molecular map of the healthy human heart to understand how this vital organ functions and to shed light on what goes awry in cardiovascular disease.

Highly detailed map of human heart could guide personalised heart treatments
Scientists have created the most detailed cellular and molecular map of the healthy human heart ever, to understand how the heart functions, and illuminate what goes wrong in cardiovascular disease.

Top Science Tip Sheet on heart failure, heart muscle cells, heart attack and atrial fibrillation results
Newly discovered pathway may have potential for treating heart failure - New research model helps predict heart muscle cells' impact on heart function after injury - New mass spectrometry approach generates libraries of glycans in human heart tissue - Understanding heart damage after heart attack and treatment may provide clues for prevention - Understanding atrial fibrillation's effects on heart cells may help find treatments - New research may lead to therapy for heart failure caused by ICI cancer medication

Machining the heart: New predictor for helping to beat chronic heart failure
Researchers from Kanazawa University have used machine learning to predict which classes of chronic heart failure patients are most likely to experience heart failure death, and which are most likely to develop an arrhythmic death or sudden cardiac death.

Molecular imaging identifies link between heart and kidney inflammation after heart attack
Whole body positron emission tomography (PET) has, for the first time, illustrated the existence of inter-organ communication between the heart and kidneys via the immune system following acute myocardial infarction.

New heart valve could transform open heart surgery for millions of patients globally
A new polymeric heart valve with a life span potentially longer than current artificial valves that would also prevent the need for the millions of patients with diseased heart valves to require life-long blood thinning tablets has been developed by scientists at the universities of Bristol and Cambridge.

Heart attacks, heart failure, stroke: COVID-19's dangerous cardiovascular complications
A new guide from emergency medicine doctors details the potentially deadly cardiovascular complications COVID-19 can cause.

Autoimmunity-associated heart dilation tied to heart-failure risk in type 1 diabetes
In people with type 1 diabetes without known cardiovascular disease, the presence of autoantibodies against heart muscle proteins was associated with cardiac magnetic resonance (CMR) imaging evidence of increased volume of the left ventricle (the heart's main pumping chamber), increased muscle mass, and reduced pumping function (ejection fraction), features that are associated with higher risk of failure in the general population

Digital heart model will help predict future heart health, new study finds
In recent times, researchers have increasing found that the power of computers and artificial intelligence is enabling more accurate diagnosis of a patient's current heart health and can provide an accurate projection of future heart health, potential treatments and disease prevention.

Read More: Heart News and Heart Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.