'Bugs' in the gut might predict dementia in the brain

January 30, 2019

DALLAS, Jan. 30, 2019 -- The makeup of bacteria and other microbes in the gut may have a direct association with dementia risk, according to preliminary research to be presented in Honolulu at the American Stroke Association's International Stroke Conference 2019, a world premier meeting for researchers and clinicians dedicated to the science and treatment of cerebrovascular disease.

Researchers studying the population of bacteria and microbes in the intestines, known as gut microbiota, have found these "bugs" impact risks for diseases of the heart and more. Japanese researchers studied 128 (dementia and non-dementia) patients' fecal samples and found differences in the components of gut microbiota in patients with the memory disorder suggesting that what's in the gut influences dementia risk much like other risk factors.

The analysis revealed that fecal concentrations of ammonia, indole, skatole and phenol were higher in dementia patients compared to those without dementia. But levels of Bacteroides - organisms that normally live in the intestines and can be beneficial - were lower in dementia patients.

"Although this is an observational study and we assessed a small number of the patients, the odds ratio is certainly high suggesting that gut bacteria may be a target for the prevention of dementia," said Naoki Saji, M.D., Ph.D., study author and vice director of the Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology in Japan.
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The National Center for Geriatrics and Gerontology and NARO Bio-oriented Technology Research Advancement Institution project funded the study.

Naoki Saji, M.D., Ph.D., Vice Director, Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

Note: Scientific presentation is 6:30 p.m. HT/11:30 p.m. ET, Wednesday, Feb. 6, 2019.

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* For more news from AHA International Stroke Conference 2019, follow us on Twitter @HeartNews #ISC19.

Statements and conclusions of study authors that are presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at https://www.heart.org/en/about-us/aha-financial-information.

About the American Stroke Association

The American Stroke Association is devoted to saving people from stroke -- the No. 2 cause of death in the world and a leading cause of serious disability. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat stroke. The Dallas-based association officially launched in 1998 as a division of the American Heart Association. To learn more or to get involved, call 1-888-4STROKE or visit StrokeAssociation.org. Follow us on Facebook and Twitter.

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